Unithiol

Brand Yerevan HFF

In stock 777 Items

Available since: 2019-09-19

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Clinical Pharmacology

Unithiol - complexing agent, has a detoxification effect.

The active sulfhydryl groups of Unithiol, interacting with thiol poisons (arsenic compounds, salts of heavy metals) and forming non-toxic water-soluble compounds with them, restore the functions of the enzyme systems of the body affected by poison.

Increases the elimination of certain cations (especially copper and zinc) from metal-containing cell enzymes.

Pharmacokinetics

When administered parenterally rapidly absorbed into the blood. The maximum concentration of the drug in the blood (C_max) is achieved in 15-30 minutes after intramuscular injection.

The half-life (T1 / 2) is 1-2 hours.

The volume of distribution is 166.5 ml / kg. The drug is distributed mainly in the aqueous phase (blood plasma). Not cumulated.

Excreted by the kidneys, mainly in the form of products of incomplete and complete oxidation, partially in unchanged form.

Indications

intoxication with arsenic, mercury, bismuth, chromium, cardiac glycosides;
hepatocerebral dystrophy (Wilson-Westfal-Konovalov disease);
chronic alcoholism (as part of complex therapy),
delirium tremens.

Composition

1 ml solution for intramuscular and subcutaneous administration contains:
active ingredients: sodium dimercaptopropanesulfonate monohydrate (unithiol) 50 mg;
excipients: disodium edetate (Trilon B), sulfuric acid 0.1 M (to pH 3.1-4.5), water d / u.

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Dosage and Administration

Unithiol is used primarily intramuscularly or subcutaneously.

When arsenic intoxication - 5-10 ml of the drug (at the rate of 0.005 g / 1 kg), in 1 day - 3-4 times, in 2 days - 2-3 times, the next - 1-2 times.
In case of poisoning with mercury compounds - in the same pattern for 6-7 days. The treatment is carried out until the disappearance of signs of intoxication.
In case of digitalis intoxication, in the first 2 days, 5-10 ml of a 5% aqueous solution is injected 3-4 times / day, then 1-2 times / day until the cardiotoxic effect ceases.
When hepatocerebral dystrophy - in / m 5-10 ml of 5% solution daily or every other day; a course of treatment is 25-30 injections; If necessary, repeat after 3-4 months.
In chronic alcoholism, 3-5 ml is prescribed 2-3 times a week.
For the relief of delirium - once 4-5 ml.

Adverse reactions

nausea,
dizziness,
tachycardia,
paleness of the skin,
allergic reactions are possible.

Contraindications

hypersensitivity to the drug Unithiol,
liver failure,
arterial hypertension,
children's age up to 18 years.

Drug interactions

The simultaneous use of Unithiol with drugs that include heavy metals and alkalis is not recommended, as Uniol is rapidly decomposed.

Pregnancy and Lactation

Contraindicated in pregnancy and lactation.

Special instructions

In case of acute poisoning, additional therapeutic measures are performed (gastric lavage, oxygen therapy, administration of dextrose, etc.).

Overdosage

Symptoms: shortness of breath, hyperkinesis, lethargy, lethargy, stupor, short-term seizures (occur when the recommended therapeutic dose is exceeded by more than 10 times).
Treatment: symptomatic therapy.