Ursodeoxycholic acid

In stock 598 Items

Available since: 2019-09-19

All payments are SSL encrypted
Full Refund if you haven't received your order
International shipping to the USA, UK and Europe

Clinical Pharmacology

Hepatoprotector. It has a choleretic effect. Reduces the synthesis of cholesterol in the liver, its absorption in the intestines and concentration in the bile, increases the solubility of cholesterol in the biliary system, stimulates the formation and excretion of bile. Reduces the lithogenicity of bile, increases the content of bile acids. It causes increased gastric and pancreatic secretion, enhances the activity of lipase.

It has a hypoglycemic effect.

It causes partial or complete dissolution of cholesterol stones when ingested, reduces the saturation of bile with cholesterol, which helps mobilize cholesterol from gallstones.

It has an immunomodulatory effect, affects the immunological reactions in the liver: reduces the expression of certain antigens on the hepatocyte membrane, affects the number of T-lymphocytes, the formation of interleukin-2, reduces the number of eosinophils.

Indications

- dissolution of cholesterol gall bladder stones;

- biliary reflux gastritis;

- primary biliary cirrhosis in the absence of signs of decompensation (symptomatic treatment);

- chronic hepatitis of various genesis;

- primary sclerosing cholangitis, cystic fibrosis (cystic fibrosis);

- non-alcoholic steatohepatitis;

- alcoholic liver disease;

- biliary dyskinesia.

Composition

1 caps - Ursodeoxycholic acid 250 mg.
Excipients: corn starch - 73 mg, colloidal silicon dioxide - 5 mg, magnesium stearate - 2 mg, titanium dioxide - 1.94 mg, gelatin - 80.51 mg, sodium lauryl sulfate - 0.2 mg, purified water - 14.55 mg.

Ursodeoxycholic acid is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Ursofalk	Dr. Falk	Germany	pills
Ursosan	PRO.MED.CS Praha a.s	Czech	capsules
			pills
Ursodez	North Star	Russia	capsules
Exhole	Canonpharma	Russia	pills
Grinterol	Grindex	Latvia	capsules
Ursofalk	Dr. Falk	Germany	capsules
Exhole	Canonpharma	Russia	capsules
Ursoliv	AVVA RUS	Russia	capsules
Urdoxa®	Pharmproject	Russia	capsules

No customer reviews for the moment.

Write your review

Dosage and Administration

Inside

For dissolving cholesterol gallstones

The average daily dose is 250-500 mg (after or during meals), which is 1-2 capsules. The course of treatment is from 4-6 months to 12 months or more. The dose for maintenance therapy is 250 mg once a day.

With biliary reflux gastritis

250 mg once daily. The course of treatment is set by the doctor.

Symptomatic treatment of primary biliary cirrhosis

The daily dose depends on body weight and ranges from 2 to 6 capsules (approximately 10 to 15 mg of ursodeoxycholic acid per 1 kg of body weight).

Recommended use:

Body weight 34-50 kg: 2 capsules (daily dose); in the morning - 1; in the afternoon - -; in the evening - 1.
Body weight 51-65 kg: 3 capsules (daily dose); in the morning - 1; in the afternoon - 1; in the evening - 1.
Body weight 66-85 kg: 4 capsules (daily dose); in the morning - 1; in the afternoon - 1; in the evening - 2.
Body weight 86-110 kg: 5 capsules (daily dose); in the morning - 1; in the afternoon - 2; in the evening - 2.
Body weight over 110 kg: 6 capsules (daily dose); in the morning - 2; in the afternoon - 2; in the evening - 2.

Adverse reactions

Backache; abdominal pain; diarrhea (can be dose-dependent); calcification of gallstones; transient (transient) increase in the activity of liver transaminases; alopecia; constipation; dizziness; nausea, vomiting; aggravation of previously existing psoriasis; allergic reactions, including urticaria.

Contraindications

X-ray (high calcium) gallstones;
nonfunctioning gallbladder;
acute inflammatory diseases: gallbladder, bile ducts, intestines;
cirrhosis of the liver in the stage of decompensation;
marked impairment of function: kidney, liver, pancreas;
pregnancy and lactation;
childhood;
hypersensitivity to the drug.

Drug interactions

Concurrent use with drugs that reduce the intestinal absorption of bile acids (eg, colestiramine) and with drugs that increase biliary elimination of cholesterol (estrogens, hormonal contraceptives, some lipid-lowering drugs) is not recommended.

Concurrent use with potentially hepatotoxic drugs is not recommended.

Pregnancy and Lactation

Contraindicated in pregnancy and lactation.

Special instructions

When taking the drug in order to dissolve gallstones, the following conditions must be met: the stones must be cholesterol (X-ray negative), their size must not exceed 15x20 mm, the gallbladder must remain functional and must be filled with not more than half of the stones, the permeability of the cystic and common gall duct must be maintained.

With a long-term (more than 1 month) administration of the drug, every 4 weeks for the first 3 months of treatment, then every 3 months, a biochemical blood test is necessary to determine the activity of hepatic transaminases.

Monitoring the effectiveness of treatment should be carried out every 6 months according to the ultrasound of the biliary tract. After complete dissolution of the stones, it is recommended to continue the use of the drug for at least 3 months in order to facilitate the dissolution of the remains of stones, the dimensions of which are too small to be detected and to prevent the recurrence of stone formation.

In patients with frequent bouts of biliary colic, with infectious diseases, changes in the pancreas or intestinal lesions that can alter the intrahepatic circulation of bile acids (bowel resection or ileostomy, limited ileitis), it is advisable to avoid using the drug.

Overdosage

Symptoms: increased side effects.

Treatment: detoxification measures and the appointment of colestyramine (for the formation of chelate complexes with bile acids).

Brand name: Ursofalk
Active ingredient: Ursodeoxycholic acid
Dosage form: Hard gelatin capsules, size No. 0, opaque, white; the contents of the capsules are white powder or granules.
Manufacturer: Dr. Falk