Validol
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Clinical Pharmacology
Validol has a moderate reflex vasodilator effect, has a sedative effect (has a calming effect on the central nervous system).
The action of the drug is largely due to reflex reactions associated with the stimulation of sensitive nerve endings. Validol in its action is close to menthol. Irritation of mucosal receptors is accompanied by stimulation of the formation and release of enkephalins, endorphins, dinorphins and peptides, which play an important role in the regulation of pain, vascular permeability and other processes. Under the influence of irritants, a number of other endogenous physiologically active compounds are released (histamine, kinins, etc.). With sublingual use, the effect of the drug develops after 5 minutes.
Indications
- angina attacks (as part of combination therapy);
- neuro-circulatory dystonia of cardiac type, functional cardialgia;
- neurosis;
- hysteria, hysterical state;
- as antiemetic at sea and air diseases.
Composition
1 tablet contains 0.06 g of menthol solution in menthyl ester of isovalerianic acid
Validol is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Validol | Altaivitamin | Russia | pills |
Validola pills | Pharmstandard | Russia | pills |
capsules | |||
Validol with glucose | pills | ||
Cormentol | K.O. Biofarm S.A | Romania | capsules |
Validol | PFK Obnovlenie | Russia | pills |
Validol with glucose | Pharmstandard | Russia | pills |
Validol capsules | Minskintercaps | Belarus | capsules |
Validol capsules | Lumy | Russia | capsules |
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Dosage and Administration
1 tab. 2-4 times a day.
A single dose for adults is 1-2 pills. Daily - 2-4 capsules. If necessary, the daily dose may be increased.
Adverse reactions
When taking validol in isolated cases, mild tearing, lacrimation, dizziness are possible; these phenomena usually quickly pass on their own.
Contraindications
Increased individual sensitivity to the components of the drug.
Severe hypotension.
- Brand name: Validol
- Active ingredient: Levomenthol solution in menthil isovalerate (Dextrose)
- Manufacturer: Altaivitamin
- Country of Origin: Russia
Studies and clinical trials of Validol (Click to expand)
- Determination of impurities in validol tablets by gas-liquid chromatography
- Study of the possible use of contour packings for validol tablets
- Use of the photometric method for the quantitative determination of validol in tablets
- A study of the composition of validol obtained from different types of raw materials
- Validol and Validol Camphoratum—Not Acceptable for A.D.R.