Vasobral®
Chiesi Pharmaceutical SpA
1380 Items
2019-09-19
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Clinical Pharmacology
Part of Vasobral alpha dihydroergocriptine - dihydrogenated derivative of ergot - blocks alpha1- and alpha2-adrenoreceptors of vascular smooth muscle cells. It has a stimulating effect on the dopamine and serotonin receptors of the central nervous system.
The use of the drug reduces platelet aggregation and red blood cells, decreases the permeability of the vascular wall, improves blood circulation and metabolic processes in the brain, increases the resistance of brain tissue to hypoxia.
CaffeineIt has a stimulating effect on the central nervous system, mainly on the cerebral cortex, respiratory and vasomotor centers. Increases mental and physical performance, reduces the feeling of fatigue.
Pharmacokinetics
When taken orally, the absorption of dihydroergocriptine is accelerated in the presence of caffeine (time to reach a maximum concentration of 0.5 hours).
The maximum concentration after oral administration of 8 mg of a-dihydroergocriptine is 227 pg / ml, and the half-life is less than 2 hours.
Indications
- decrease in mental activity, impaired attention and memory, impaired orientation in space, caused by age-related changes;
- cerebrovascular insufficiency (including due to cerebral atherosclerosis);
- consequences of cerebral circulation;
- migraine prophylaxis;
- vestibular and labyrinth disorders (dizziness, tinnitus, hypoacuse) of ischemic genesis;
- Meniere's disease;
- retinopathy (diabetic and hypertensive);
- disorders of the peripheral arterial circulation (Raynaud's syndrome and disease);
- venous insufficiency.
Composition
1 tablet contains:
active ingredients: alpha-dihydroergocriptine mesylate 4 mg, caffeine 40 mg;
excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, anhydrous silicon colloid dioxide
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Dosage and Administration
Inside (at the time of delivery, with a small amount of liquid) on 1 \ 2-1 tablet 2 times a day. Duration of treatment is 2-3 months, if necessary, treatment can be carried out 1-2 times a year.
Adverse reactions
From the digestive system: rarely - nausea, epigastric pain, dyspepsia.
From the side of the central nervous system: rarely (no more than 1%) - dizziness, headache, agitation.
Since the cardiovascular system: very rarely (no more than 0.1%) - tachycardia, arterial hypotension.
Allergic reactions:very rarely (no more than 0.1%) - itchy skin, rash.
Contraindications
Hypersensitivity to the drug; pregnancy; lactation period.
Drug interactions
With simultaneous appointment of Vasobral®a and antihypertensive drugs may develop arterial hypotension. Caffeine weakens the effect of hypnotic drugs.
Pregnancy and Lactation
There is no clinical data on the use of Vasobral during pregnancy and lactation. The use of the drug during breastfeeding can lead to a decrease in lactation.
Special instructions
Vasobral has a vasodilating effect without affecting the systemic arterial pressure. Appointment of Vasobral patients with hypertension does not exclude the need for the use of antihypertensive agents. Caffeine contained in the drug can cause sleep disturbance, tachycardia.
Overdosage
Symptoms - increased severity of side effects. Symptomatic treatment.
- Brand name: Vasobral
- Active ingredient: Dihydroergocriptine, Caffeine
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