Vicasol® [Menadione sodium bisulfite]
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Antihemorrhagic agent. It is a synthetic analogue of vitamin K. It is a cofactor for the synthesis of prothrombin and other blood coagulation factors (VII, IX, X) in the liver, contributes to the normalization of the blood coagulation process.
Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, cirrhosis of the liver, prolonged diarrhea); hemorrhagic disease of the newborn; bleeding after injuries, injuries and surgical interventions; in gynecology as part of complex treatment of dysfunctional uterine bleeding, not associated with organic pathology, in menorrhagia. As a specific antagonist in bleeding associated with the administration of indirect anticoagulants. III trimester of pregnancy (to prevent bleeding in newborns).
1 ampoule (1 ml) contains 10 mg of menadione sodium bisulfite
Menadione sodium bisulfite is marketed under different brands and generic names, and comes in different dosage forms:
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Dosage and Administration
Vicasol prescribed by mouth for 15-30 mg per day for adults.
Children under the age of 1 year - 2-5 mg per day, from 1 to 2 years old - 6 mg per day, 3-4 years - 8 mg per day, 5-9 years - 10 mg per day, 10- 14 years - 15 mg per day. Reception frequency - 2-3 times a day.
The maximum daily dose of the drug for newborns - 4 mg.
Duration of treatment is 3-4 days. The course of treatment is repeated after 4 days break.
- hemolytic anemia;
- jaundice, especially in premature babies;
- hemolysis in newborns with congenital glucose – 6-phosphate dehydrogenase deficiency.
- deficiency of 6-phosphate dehydrogenase;
- liver failure;
Reduces or blocks the anticoagulant action of neodicoumarin and fenilina. Does not affect the anticoagulant activity of heparin. Simultaneous administration with broad-spectrum antibiotics, quinidine, quinine, high-dose salicylates, antibacterial sulfonamides requires an increase in the dose of vitamin K.
Pregnancy and Lactation
It is used during pregnancy according to indications.
In hemophilia, von Willebrand and Verlhof disease, the drug is ineffective.
When glucose-6-phosphate dehydrogenase is deficient, it can cause hemolysis.
Rarely - hypervitaminosis K, manifested hyperprothrombin- and hyperthrombinemia, hyperbilirubinemia, increased blood clotting, thromboembolism. Symptomatic treatment.
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- Note on the quantitative determination of menadione sodium bisulfite
- Amperometric monitoring of redox activity in living yeast cells: comparison of menadione and menadione sodium bisulfite as electron transfer mediators
- The second chemiluminescence emission of luminol–periodate–menadione sodium bisulfite system and its analytical application
- Detection of menadione sodium bisulfite (vitamin K3) by reversed-phase high performance liquid chromatography with series dual-electrode amperometric detector
- Study on sensitized photochemical fluorescence of menadione sodium bisulfite and its application in pharmaceutics analysis
- Fluorimetric determination of vitamin k3 (menadione sodium bisulfite) in synthetic animal feed by high-performance liquid chromatography using a post-column zinc reducer
- Chemiluminescence analysis of menadione sodium bisulfite and analgin in pharmaceutical preparations and biological fluids
- Increase in plasma fibrin clot elesticity in vivo and in vitro due to menadione sodium bisulfite
- The influence of sodium ascorbate, menadione sodium bisulfite or pyridoxal hydrochloride on the toxic and antineoplastic action of N-methylformamide in P 388 leukemia or M 5076 sarcoma in mice
- Study on the electrochemiluminescent behavior of menadione sodium bisulfite in presence of luminol
- Problems associated with the present use of menadione sodium bisulfite and vitamin A in diets for Atlantic salmon
- Spectrophotometric determination of menadione and menadione sodium bisulfite in pharmaceutical preparations
- Solubilities of Menadione Sodium Bisulfite in Water + (Methanol, Ethanol, 1-Propanol, 2-Propanol, 1,2-Propanediol, and Glycerin, Respectively) from (297.67 to 337.76) K
- Effect of Menadione Sodium Bisulfite, an Inducer of Plant Defenses, on the Dynamic of Banana Phytoalexin Accumulation during Pathogenesis
- Chemiluminescence Flow Injection Analysis of Menadione Sodium Bisulfite Based on Luminol Reaction
- Activity of Vitamin K1 and Menadione Sodium Bisulfite Complex When Measured by Mortality of Chicks with Cecal Coccidiosis
- Menadione Sodium Bisulfite Complex (Klotogen F(R) in Cecal Coccidiosis
- Control of Hemorrhagic Condition in Chickens with Menadione Sodium Bisulfite
- Relationship of Dietary Menadione Sodium Bisulfite Complex (MSBC) and Vitamin A to Blood Spot Incidence and Prothrombin Time of Laying Hens,
- Validation of a Stability-Indicating Hydrophilic Interaction Liquid Chromatographic Method for the Quantitative Determination of Vitamin K3 (Menadione Sodium Bisulfite) in Injectable Solution Formulation
- Comparison of Vitamin K Activities of Vitamin K1 and Klotogen (Menadione Sodium Bisulfite Complex)
- Different characteristics between menadione and menadione sodium bisulfite as redox mediator in yeast cell suspension
- Chemiluminescent Determination of Menadione Sodium Bisulfite
- Determination of Menadione Sodium Bisulfite in Pharmaceutical Preparations by Flow-Injection On-line Photochemical Spectrofluorometry.