Buy Vicasol injection 1% ampoules 1%, 1 ml, 10 pcs
  • Buy Vicasol injection 1% ampoules 1%, 1 ml, 10 pcs

Vicasol® [Menadione sodium bisulfite]

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Clinical Pharmacology

Antihemorrhagic agent. It is a synthetic analogue of vitamin K. It is a cofactor for the synthesis of prothrombin and other blood coagulation factors (VII, IX, X) in the liver, contributes to the normalization of the blood coagulation process.


Hemorrhagic syndrome associated with hypoprothrombinemia; hypovitaminosis K (including with obstructive jaundice, hepatitis, cirrhosis of the liver, prolonged diarrhea); hemorrhagic disease of the newborn; bleeding after injuries, injuries and surgical interventions; in gynecology as part of complex treatment of dysfunctional uterine bleeding, not associated with organic pathology, in menorrhagia. As a specific antagonist in bleeding associated with the administration of indirect anticoagulants. III trimester of pregnancy (to prevent bleeding in newborns).


1 ampoule (1 ml) contains 10 mg of menadione sodium bisulfite

Menadione sodium bisulfite is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Vicasol Dalkhimpharm Russia ampoules
Vicasol Pharmstandard Russia pills
Vicasol Ellara Russia ampoules

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Vicasol® [Menadione sodium bisulfite]

Dosage and Administration

Vicasol prescribed by mouth for 15-30 mg per day for adults.

Children under the age of 1 year - 2-5 mg per day, from 1 to 2 years old - 6 mg per day, 3-4 years - 8 mg per day, 5-9 years - 10 mg per day, 10- 14 years - 15 mg per day. Reception frequency - 2-3 times a day.

The maximum daily dose of the drug for newborns - 4 mg.
Duration of treatment is 3-4 days. The course of treatment is repeated after 4 days break.

Adverse reactions

  • hemolytic anemia;
  • hyperbilirubinemia;
  • jaundice, especially in premature babies;
  • hemolysis in newborns with congenital glucose – 6-phosphate dehydrogenase deficiency.


  • deficiency of 6-phosphate dehydrogenase;
  • liver failure;
  • pregnancy.

Drug interactions

Reduces or blocks the anticoagulant action of neodicoumarin and fenilina. Does not affect the anticoagulant activity of heparin. Simultaneous administration with broad-spectrum antibiotics, quinidine, quinine, high-dose salicylates, antibacterial sulfonamides requires an increase in the dose of vitamin K.

Pregnancy and Lactation

It is used during pregnancy according to indications.

Special instructions

In hemophilia, von Willebrand and Verlhof disease, the drug is ineffective.

When glucose-6-phosphate dehydrogenase is deficient, it can cause hemolysis.


Rarely - hypervitaminosis K, manifested hyperprothrombin- and hyperthrombinemia, hyperbilirubinemia, increased blood clotting, thromboembolism. Symptomatic treatment.

Studies and clinical trials of Menadione sodium bisulfite (Click to expand)
  1. Impact of Vesomni™ on quality of life of men with lower urinary tract symptoms associated with benign prostatic hyperplasia in routine clinical practice: Interim results from the EUROPA study
  2. Note on the quantitative determination of menadione sodium bisulfite
  3. Amperometric monitoring of redox activity in living yeast cells: comparison of menadione and menadione sodium bisulfite as electron transfer mediators
  4. The second chemiluminescence emission of luminol–periodate–menadione sodium bisulfite system and its analytical application
  5. Detection of menadione sodium bisulfite (vitamin K3) by reversed-phase high performance liquid chromatography with series dual-electrode amperometric detector
  6. Study on sensitized photochemical fluorescence of menadione sodium bisulfite and its application in pharmaceutics analysis
  7. Fluorimetric determination of vitamin k3 (menadione sodium bisulfite) in synthetic animal feed by high-performance liquid chromatography using a post-column zinc reducer
  8. Chemiluminescence analysis of menadione sodium bisulfite and analgin in pharmaceutical preparations and biological fluids
  9. Increase in plasma fibrin clot elesticity in vivo and in vitro due to menadione sodium bisulfite
  10. The influence of sodium ascorbate, menadione sodium bisulfite or pyridoxal hydrochloride on the toxic and antineoplastic action of N-methylformamide in P 388 leukemia or M 5076 sarcoma in mice
  11. Study on the electrochemiluminescent behavior of menadione sodium bisulfite in presence of luminol
  12. Problems associated with the present use of menadione sodium bisulfite and vitamin A in diets for Atlantic salmon
  13. Spectrophotometric determination of menadione and menadione sodium bisulfite in pharmaceutical preparations
  14. Solubilities of Menadione Sodium Bisulfite in Water + (Methanol, Ethanol, 1-Propanol, 2-Propanol, 1,2-Propanediol, and Glycerin, Respectively) from (297.67 to 337.76) K
  15. Effect of Menadione Sodium Bisulfite, an Inducer of Plant Defenses, on the Dynamic of Banana Phytoalexin Accumulation during Pathogenesis
  16. Chemiluminescence Flow Injection Analysis of Menadione Sodium Bisulfite Based on Luminol Reaction
  17. Activity of Vitamin K1 and Menadione Sodium Bisulfite Complex When Measured by Mortality of Chicks with Cecal Coccidiosis
  18. Menadione Sodium Bisulfite Complex (Klotogen F(R) in Cecal Coccidiosis
  19. Control of Hemorrhagic Condition in Chickens with Menadione Sodium Bisulfite
  20. Relationship of Dietary Menadione Sodium Bisulfite Complex (MSBC) and Vitamin A to Blood Spot Incidence and Prothrombin Time of Laying Hens,
  21. Validation of a Stability-Indicating Hydrophilic Interaction Liquid Chromatographic Method for the Quantitative Determination of Vitamin K3 (Menadione Sodium Bisulfite) in Injectable Solution Formulation
  22. Comparison of Vitamin K Activities of Vitamin K1 and Klotogen (Menadione Sodium Bisulfite Complex)
  23. Different characteristics between menadione and menadione sodium bisulfite as redox mediator in yeast cell suspension
  24. Chemiluminescent Determination of Menadione Sodium Bisulfite
  25. Determination of Menadione Sodium Bisulfite in Pharmaceutical Preparations by Flow-Injection On-line Photochemical Spectrofluorometry.

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