Buy Vicks AntiGrip powder 5 pcs
  • Buy Vicks AntiGrip powder 5 pcs

Vicks AntiGrip

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2019-09-19
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Clinical Pharmacology

Combined drug, the action of which is due to the composition of its constituent components.
Paracetamol has an analgesic and antipyretic effect.
Guaifenesin has a mucolytic effect, facilitates the removal of sputum from the bronchi and contributes to the transition of unproductive cough to productive.
Phenylephrine is a sympathomimetic, has pronounced alpha-adrenergic activity, narrows the vessels of the nasal mucosa, eliminates puffiness and hyperemia of the nasal mucosa.
Pharmacokinetics
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract. After ingestion of Cmax paracetamol in plasma is reached in 10-60 minutes. Metabolized in the liver and excreted in the urine, mainly in the form of glucuronides and sulfate compounds. T1 / 2 is 1-3 hours.
Guaifenesin is rapidly absorbed from the gastrointestinal tract (25-30 minutes after ingestion). T1 / 2 - 1 hour. Metabolized in the liver by oxidation to β- (2-methoxy-phenoxy) -lactic acid, which is excreted in sputum and kidneys as inactive metabolites.
Phenylephrine has an irregular absorption from the gastrointestinal tract and at the first stage of metabolism is exposed to monoamine oxidase in the intestine and liver, therefore oral administration of phenylephrine reduces its bioavailability. Excreted in the urine as sulfate compounds. Cmax in plasma is achieved in 1-2 hours, T1 / 2 is 2-3 hours.

Indications

Symptoms of colds and flu (headache, sore throat, pain in the body and limbs, nasal congestion, cough with difficult coughing up sputum, fever).

Composition

Excipients: sucrose - 2000 mg, citric acid - 330 mg, tartaric acid - 330 mg, sodium cyclamate - 200 mg, sodium citrate - 500 mg, aspartame - 6 mg, ascorbic acid - 100 mg, potassium acesulfame - 17 mg, flavoring lemon 8476 - 50 mg, lemon juice flavor - 120 mg, menthol flavor - 100 mg, quinoline yellow dye - 1 mg.

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Vicks AntiGrip

Dosage and Administration

Orally, before a meal or after 1 -2 hours after a meal, drinking plenty of water.

  • Adults and children over 12 years old (body weight more than 40 kg): 1-2 pills every 4-6 hours. Reception frequency no more than 4 times a day with an interval of at least 4 hours.
  • Children aged 9 to 12 years (body weight more than 30 kg): 1 tablet every 4-6 hours. Reception frequency no more than 4 times a day with an interval of at least 4 hours.

The drug is not recommended to use more than 5 days as an anesthetic and 3 days as an antipyretic without consulting a doctor. If symptoms persist, consult a doctor.

Do not exceed the specified dose.

Adverse reactions

Allergic reactions (skin rash, skin flushing, urticaria, angioedema) may occur.

Paracetamol: blood disorders (anemia, thrombocytopenia, methemoglobinemia).

Phenylephrine: headache, nausea, or vomiting; angina pectoris, bradycardia, dyspnea, increase or decrease in blood pressure, heartbeat, tachycardia, ventricular arrhythmia (especially when used in high doses), irritability, motor restlessness, allergic reactions.

Vitamin C: may cause irritation of the gastrointestinal mucosa, with prolonged use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the gastrointestinal mucosa; decrease in capillary permeability (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, microangiopathy development). It is also possible the occurrence of thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glycosuria, inhibition of the function of the insular apparatus of the pancreas.

With prolonged use in doses significantly higher than recommended, increases the likelihood of impaired renal function (moderate pollakiuria, hyperoxaluria, nephrolithiasis, damage to the glomerular apparatus of the kidneys), increased central nervous system excitability, headache, insomnia.

In case of adverse reactions, consult a doctor.

Contraindications

Carefully:

  • With a deficiency of glucose-6-phosphate dehydrogenase.
  • With benign hyperbilirubinemia.
  • Pregnancy.
  • Lactation.
  • Elderly age.

Drug interactions

The drug enhances the effects of monoamine oxidase inhibitors, sedatives, ethanol.

The risk of the development of hepatotoxic action of paracetamol increases with simultaneous administration of ethanol, hepatotoxic drugs, inducers of microsomal oxidation enzymes in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants, etc.).

The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (reduced synthesis of procoagulant factors in the liver). Paracetamol reduces the effectiveness of uricosuric drugs.

Prolonged use of barbiturates reduces the effectiveness of paracetamol. Metoclopramide and domperidone increase, and Kolestiramin reduces the rate of absorption of paracetamol. Inhibitors of microsomal oxidation enzymes (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

The simultaneous use of ethanol and paracetamol contributes to the development of acute pancreatitis. Long-term combined use of paracetamol and nonsteroidal anti-inflammatory drugs increases the risk of "analgesic" nephropathy and renal papillary necrosis, the onset of end-stage renal failure. The simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity. Myelotoxic drugs enhance the manifestations of paracetamol hematotoxicity.

Phenylephrine reduces the hypotensive effect of diuretics and antihypertensive drugs (including methyldopa, mecamylamine, guanadrela, guanethidine), reduces the antianginal effect of nitrates.

Phenothiazines, alpha-blockers (phentolamine), furosemide and other diuretics reduce the hypertensive effect of pheniramine. Mono-oxidase inhibitors (including furazolidone, procarbazine, selegiline), oxytocin, ergot alkaloids, tricyclic antidepressants, methylphenidate, adrenomimetics vasoconstrictor effect and enhance arrhythmogenic phenylephrine, against reserpine possible hypertension. Ergometrine, ergotamine, methylergometrine, oxytocin, doxapram increase the intensity of the vasoconstrictor effect of pheniramine.

Inhalation anesthetics (including chloroform, enflurane, halothane, isoflurane, methoxyflurane) increase the risk of severe atrial and ventricular arrhythmias. Thyroid hormones increase (mutually) the effect of phenylephrine and the associated risk of coronary insufficiency (especially with coronary atherosclerosis).

Ascorbic acid increases the blood concentration of benzylpenicillin and tetracyclines reduces the effectiveness of heparin and indirect anticoagulants, increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body, reduces the therapeutic action of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

With simultaneous use with acetylsalicylic acid increases the excretion of urine ascorbic acid and decreases the excretion of acetylsalicylic acid. Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce the absorption and absorption of ascorbic acid.

Ascorbic acid improves the absorption of iron preparations in the intestine; increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows the kidneys excretion of acids, increases the excretion of drugs having an alkaline reaction (including alkaloids), reduces the concentration in the blood of oral contraceptives, reduces the chronotropic effect of isoprenaline. With long-term use or use in high doses may interfere with the interaction of disulfiram and ethanol, in high doses increases the excretion of meksiletin kidneys.

Drugs quinoline series, calcium chloride, salicylates, glucocorticoids with long-term use deplete reserves of ascorbic acid. Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Pregnancy and Lactation

With care during pregnancy and lactation.

Special instructions

Before taking the drug, it is necessary to consult a doctor in case of concomitant use of metoclopramide, domperidone, colestiramine (due to the fact that metoclopramide and domperidone increase, and colestiramine reduces the rate of absorption of paracetamol), anticoagulants (because the concomitant use of paracetamol in high doses increases the effect of anticoagulant medicines).

The drug intake distorts the results of laboratory tests assessing the concentration of glucose and uric acid in plasma.

When using the drug for more than 5-7 days, monitor peripheral blood levels and the functional state of the liver.

The use of the drug during pregnancy is possible only on prescription.

In order to avoid toxic damage to the liver, the drug should not be combined with the intake of alcoholic beverages, as well as be taken by persons with chronic alcoholism.

Influence on ability to drive motor transport and control mechanisms

The drug does not adversely affect the performance of potentially hazardous activities that require special attention and quick reactions.

Overdosage

In case of overdose, seek medical attention immediately, even if you feel well, as there is a risk of delayed signs of serious liver damage.

Overdose symptoms are usually caused by exposure to high doses of paracetamol.

Symptoms: during the first 24 hours after ingestion - pale skin, nausea, vomiting, anorexia, abdominal pain; violation of glucose metabolism, metabolic acidosis. Symptoms of abnormal liver function may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis. Hepatotoxic effect in adults appears when taking 10 g or more.

Treatment: the introduction of SH-grypp donators and precursors of glutathione-methionine synthesis during 8-9 hours after overdose and acetylcysteine ​​- within 8 hours. The need for additional therapeutic measures (further introduction of methionine, intravenous acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as from the time elapsed after its reception.

  • Brand name: Vicks AntiGrip
  • Active ingredient: Paracetamol, Phenylephrine
  • Dosage form: Powder for the preparation of oral solution
  • Manufacturer: Procter and Gamble Manufacturing GmbH

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