Vitamin E

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Available since: 2019-09-19

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Clinical Pharmacology

Vitamin has an antioxidant effect, is involved in the biosynthesis of heme and proteins, cell proliferation, tissue respiration, other important processes of tissue metabolism, prevents red blood cell hemolysis, reduces the increased permeability and capillary fragility. It is necessary for the development and functioning of connective tissue, smooth and skeletal muscles, as well as for strengthening the walls of blood vessels. Takes part in the metabolism of nucleic acids and prostaglandins, the cellular respiratory cycle, in the synthesis of arachidonic acid.

It is a natural antioxidant, inhibits lipid peroxidation by free radicals. It activates phagocytosis and is used to maintain the normal resistance of red blood cells. In large doses, it prevents platelet aggregation.
It has a pronounced positive effect on the human reproductive system, slows down the development of atherosclerotic vascular changes.

Indications

prevention and treatment of vitamin E hypovitaminosis;
in the treatment of hormonal treatment of menstrual disorders, degenerative and proliferative changes in the joints and ligaments, spine, muscular dystrophy, and amyotrophic lateral sclerosis;
state of convalescence after illness;
poor and unbalanced nutrition;
increased exercise.

Composition

Gelatin capsule (gelatin, E422), linseed oil, alpha-tocopherol acetate, complex food additive "Grindoks 539"

Vitamin E is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Vitamin E	PFK Obnovlenie	Russia	capsules
alpha tocopherol acetate	Vitamin E) (Meligen	Russia	capsules
Vitamin E	Mirrolla	Russia	Other
alpha tocopherol acetate	Vitamin E) (Marbiopharm	Russia	bottle
alpha tocopherol acetate	Vitamin E) (Ecolab	Russia	vials
Vitamin E	Minskintercaps	Belarus	capsules
alpha tocopherol acetate	Vitamin E) (Lumy	Russia	capsules
alpha tocopherol acetate	Vitamin E) (Marbiopharm	Russia	capsules

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Dosage and Administration

Adults: 100 mg capsules - 2-4 caps / day; 200 mg capsules - 1-2 capsules / day; 400 mg capsules - 1 capsule / day.
For violations of the menstrual cycle (as a supplement to hormone therapy) 300-400 mg every other day, sequentially, starting from the 17th day of the cycle.

Adverse reactions

Possible: allergic reactions.
On the part of the digestive system: diarrhea, nausea, gastralgia.
Rarely, in patients with predisposition, creatinuria, an increase in the activity of creatine kinase, an increase in serum cholesterol level, thrombophlebitis, pulmonary thromboembolism, and thrombosis occur.

With caution used in patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypoprothrombinemia caused by vitamin K deficiency may worsen when using vitamin E in a dose of more than 400 IU.

Drug interactions

Enhances the effect of GCS, NSAIDs, cardiac glycosides. Increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have elevated blood lipid peroxidation products in the blood).
Iron increases the daily need for vitamin E.
Vitamin E enhances the effect of anticoagulants if the doses exceed 400 ME / day.
It is not recommended to take other vitamin complexes containing vitamin E at the same time in order to avoid overdosing.
The administration of high-dose vitamin E may cause a deficiency in vitamin A in the body.
The simultaneous use of vitamin E in a dose of more than 400 ME per day with anticoagulants (coumarin and indandion derivatives) increases the risk of developing hypothrombinemia and bleeding.
Kolestiramin, Kolestipol, mineral oils reduce absorption.

Pregnancy and Lactation

During pregnancy and breastfeeding, taking the drug only on the recommendation of a doctor

Overdosage

High doses of vitamin E (400-800 mg / day for a long time) can cause visual impairment, diarrhea, dizziness, headache, nausea, severe fatigue, fainting, white hair growth in areas of alopecia with vesicular epidermolysis.
Very high doses (exceeding 800 mg for a long time) can cause bleeding in patients with vitamin K deficiency; they can interfere with the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolism in sensitive patients.