Xantinol nicotinate
Usolye-Sibirsky HFZ
582 Items
2019-09-19
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Clinical Pharmacology
Xantinol nicotinate - microcirculation improving agent; combines the properties of theophylline and nicotinic acid. It causes the expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and tissue nutrition. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity.
Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the amount of cAMP in the cell, and substrate stimulates the synthesis of NAD and NADP.
Reducing round focal disease and increasing myocardial contractions, increases the minute volume of blood and enhances cerebral circulation, reduces the severity of cerebral hypoxia.
It causes nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: it exacerbates the olfactory and taste sensitivity. In this regard, the smell and taste of alcoholic beverages and dishes offered during the nicotine-like reaction is perceived more sharp and unpleasant.
With prolonged use, it has an anti-atherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, reduces platelet aggregation.
Indications
Obliterating endarteritis, vascular atherosclerosis of the lower extremities, intermittent claudication, Raynaud's disease, diabetic angiopathy, arterial thrombosis, retinopathy, trophic ulcers of the lower extremities, atherosclerotic disorders of cerebral circulation, migraine, Meniere's syndrome, dermatosis, acute asthma, acute cerebral circulation
Composition
1 tablet contains
Active substance: xantinol nicotinate - 150 mg;
Excipients: corn starch, lactose (milk sugar), povidone (polyvinylpyrrolidone), calcium stearate monohydrate (calcium stearate 1-water).
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Dosage and Administration
Intranasal. Adults and children over 6 years: 2-3 drops in each nasal passage 2-3 times / day.
Do not use more than 3 times / day.
Adverse reactions
When applied, it can cause a burning sensation in the nose and throat, local irritation, paresthesia, sneezing, hypersecretion, dryness of the nasal mucosa. Allergic reactions are possible.
Rarely - swelling of the nasal mucosa, palpitations, tachycardia, arrhythmias, increased blood pressure, headache, nausea, vomiting, insomnia, blurred vision; depression (with prolonged use in high doses).
If symptoms occur, discontinue use and consult a doctor.
- arterial hypertension;
- tachycardia;
- pronounced atherosclerosis;
- glaucoma;
- atrophic rhinitis;
- thyrotoxicosis;
- Surgery on the meninges (in history);
- pregnancy;
- children's age (up to 6 years);
- Hypersensitivity to the drug.
With care: lactation, ischemic heart disease (angina), prostatic hyperplasia, diabetes mellitus.
Drug interactions
Do not use simultaneously with MAO inhibitors and tricyclic antidepressants.
Pregnancy and Lactation
The drug is contraindicated in pregnancy. With caution - during lactation.
Special instructions
Frequent and long-term use in chronic diseases of the nasopharynx is not recommended. For colds, when crusts form in the nose, it is preferable to administer as a gel.
Overdosage
Symptoms: Accidental poisoning ksilometazolina when taking it into possible mydriasis, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmia, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory disorders, personality disorders, inhibition of CNS functions accompanied by drowsiness , decrease in body temperature, bradycardia, hypotension, apnea, coma.
Treatment: gastric lavage, the appointment of Activated charcoal, if necessary, mechanical ventilation. To reduce blood pressure - phentolamine IV slowly in a dose of 5 mg or inside a dose of 100 mg.
Vasopressor agents are contraindicated. If necessary, use antipyretic and anticonvulsant drugs.
- Brand name: Xantinol nicotinate
- Active ingredient: Xantinol nicotinate
- Dosage form: Pills
- Manufacturer: Usolye-Sibirsky HFZ
- Country of Origin: Russia
Studies and clinical trials of Xantinol nicotinate (Click to expand)
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