Xantinol nicotinate
Usolye-Sibirsky HFZ
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Clinical Pharmacology
Xantinol nicotinate - microcirculation improving agent; combines the properties of theophylline and nicotinic acid. It causes the expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and tissue nutrition. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity.
Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the amount of cAMP in the cell, and substrate stimulates the synthesis of NAD and NADP.
Reducing round focal disease and increasing myocardial contractions, increases the minute volume of blood and enhances cerebral circulation, reduces the severity of cerebral hypoxia.
It causes nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: it exacerbates the olfactory and taste sensitivity. In this regard, the smell and taste of alcoholic beverages and dishes offered during the nicotine-like reaction is perceived more sharp and unpleasant.
With prolonged use, it has an anti-atherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, reduces platelet aggregation.
Indications
Obliterating endarteritis, vascular atherosclerosis of the lower extremities, intermittent claudication, Raynaud's disease, diabetic angiopathy, arterial thrombosis, retinopathy, trophic ulcers of the lower extremities, atherosclerotic disorders of cerebral circulation, migraine, Meniere's syndrome, dermatosis, acute asthma, acute cerebral circulation
Composition
1 tablet contains
Active substance: xantinol nicotinate - 150 mg;
Excipients: corn starch, lactose (milk sugar), povidone (polyvinylpyrrolidone), calcium stearate monohydrate (calcium stearate 1-water).
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Dosage and Administration
Inside, after eating, without chewing, - 1 (if necessary, 2-4) tablet 3 times a day, for 2 months.
Adverse reactions
Since the cardiovascular system:possible decrease in blood pressure, transient sensation of heat, redness of the skin.
From the digestive system: rarely - nausea, diarrhea, anorexia, gastralgia; with prolonged use in high doses, it is possible to increase the level of transaminases and alkaline phosphatase.
Other: weakness, dizziness; with prolonged use in high doses, it is possible to change the tolerance to glucose, an increase in the level of uric acid in the blood serum.
Contraindications
Bleeding, myocardial infarction, congestive heart failure, gastric ulcer and duodenal ulcer, the first trimester of pregnancy.
Drug interactions
With simultaneous use with drugs that have a hypotensive effect (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglioblockers), with strophanthin, a sharp increase in their action is possible.
Special instructions
With caution used in labile blood pressure.
With caution used simultaneously with antihypertensive drugs.
Influence on ability to drive motor transport and control mechanisms
Use with extreme caution in drivers of vehicles, as well as in patients engaged in potentially hazardous activities.
- Brand name: Xantinol nicotinate
- Active ingredient: Xantinol nicotinate
- Dosage form: Pills
- Manufacturer: Usolye-Sibirsky HFZ
- Country of Origin: Russia
Studies and clinical trials of Xantinol nicotinate (Click to expand)
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