Buy Rinonorm-Teva spray 0.1% 20 ml
  • Buy Rinonorm-Teva spray 0.1% 20 ml

Xylometazoline

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2019-09-19
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Clinical Pharmacology

Clinico-pharmacological group: Vasoconstrictor drug for local use in ENT practice

Pharmaco-therapeutic group: Anti-conductive agent - vasoconstrictor (alpha adrenergic)

pharmachologic effect

Alpha adrenergic for local application in an ENT-practice.

When applied topically, xylometazoline causes a narrowing of the arterioles, leading to a decrease in hyperemia and swelling of the mucous membranes of the nasopharynx and a decrease in secretion. Distinct local action of the drug is detected within a few minutes and lasts for several hours (up to 6-8 hours), manifesting itself in the restoration of the patency of the nasal passages, the openings of the sinuses and the Eustachian tubes. Restoration of air flow in the nasopharynx improves the patient's well-being and reduces the risk of possible complications caused by the stagnation of mucous secretions.

Pharmacokinetics

With topical administration, xylometazoline is practically not absorbed, so plasma concentrations are very low (not analytically determined).

Indications

Rinonorm is used as a symptomatic therapy for the following diseases and conditions:

- acute viral or bacterial rhinitis;

- acute allergic rhinitis;

- acute sinusitis or exacerbation of chronic sinusitis;

- acute otitis media (to reduce swelling of the mucous membrane of the Eustachian tube);

- preparing the patient for diagnostic procedures in the nasal passages.

Composition

1 ml
xylometazoline hydrochloride 1 mg

Excipients: citric acid monohydrate, sodium citrate dihydrate, glycerol 85%, water d / u.

Xylometazoline is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
spray
Dlyanos Novartis Switzerland spray
Renomaris Jadran-Galensky Laboratories ao Croatia spray
Xylometazolin-SOLOpharm Grotex Ltd Russia spray
Xylometazolin-SOLOpharm Grotex Ltd Russia drops
Xymelin Takeda GmbH Japan drops
Renorus Synthesis AKOMP Russia spray
Golden star Noz Danafa Pharmaceutical Joint Vietnam drops
Sanorin-xylo Merkle GmbH Germany drops
Rhinostop Pharmstandard Russia spray
Eucazolin Aqua Farmak Ukraine spray
Xylen Veropharm Russia spray
Xylometazoline Vips Med Firm Russia spray
Renorus Synthesis AKOMP Russia drops
Golden star Noz Danafa Pharmaceutical Joint Vietnam spray
Rhinostop Lecco Russia drops
Otrivin Novartis Switzerland spray
Xymelin Takeda GmbH Japan spray
Snoop Ursapharm Artsnaymittel Germany spray
Xylen Veropharm Russia drops
Dlyanos Novartis Switzerland drops
Galazolin Polfa Poland drops

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Xylometazoline

Dosage and Administration

Adults and children over 6 years old 2-3 drops of 0.1% solution are instilled into each nasal passage 3-4 times a day.

Children from 2 to 6 years Instill a 0.05% solution of 1-2 drops in each nasal passage - 1-2 times a day. Do not use more than 3 times a day.

Duration of treatment - no more than 3-5 days (without a break).

Before using the drug, unscrew the cap of the bottle and instill into the nose by gently pressing the bottom of the bottle.

Adverse reactions

Local reactions:with frequent and / or long-term use - irritation and / or dryness of the nasopharyngeal mucosa, burning, paresthesia, sneezing, hypersecretion; rarely - swelling of the nasal mucosa.

Systemic reactions: vomiting, headache, palpitations, increased blood pressure, insomnia, blurred vision, depression (with prolonged use of high doses).

Contraindications

Hypersensitivity to xylometazoline, arterial hypertension, tachycardia, marked atherosclerosis, glaucoma, atrophic rhinitis, hyperthyroidism, surgical interventions on the meninges (in history), pregnancy, child age (up to 6 years for 0.1% solution and for 0.05% solution - to 2 years).
Do not use in the treatment of monoamine oxidase inhibitors and tricyclic antidepressants.

Carefully: diabetes mellitus, lactation, ischemic heart disease, angina III-IV functional class, prostatic hyperplasia.

Drug interactions

It is possible to enhance the systemic action with the simultaneous use of monoamine oxidase inhibitors (MAO) and tricyclic antidepressants.

Pregnancy and Lactation

During pregnancy and lactation, the drug should be used only after a careful assessment of the ratio of benefits for the mother and the risk to the fetus and child, with caution, it is not allowed to exceed the recommended doses.

Special instructions

Do not exceed the recommended dose and apply for a long time.
Before use, you must clean the nasal passages.
Do not use for more than 7 days.

Overdosage

Symptoms:increased side effects.

Treatment: symptomatic under medical supervision.

  • Brand name: Rinonorm-Teva
  • Active ingredient: Xylometazoline
  • Dosage form: Spray nasal dosed
  • Manufacturer: Jadran-Galensky Laboratories ao.

Studies and clinical trials of Xylometazoline (Click to expand)

  1. High-performance liquid chromatographic method for the assay of dexamethasone and xylometazoline in nasal drops containing methyl p-hydroxybenzoate
  2. A comparative analysis of the decongestive effect of oxymetazoline and xylometazoline in healthy subjects
  3. Determination of xylometazoline in plasma and urine by gas chromatography using a fused-silica capillary column and an electron-capture detector
  4. Rosacea (erythematotelangiectatic type) effectively improved by topical xylometazoline
  5. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline
  6. Kinetics of hydrolysis of xylometazoline (XYL) in aqueous solution
  7. Effect of xylometazoline and antazoline on ciliary beat frequency
  8. Computer-assisted video measurement of inhibition of ciliary beat frequency of human nasal epithelium in vitro by xylometazoline
  9. A comparison of the sensitivity of manometric rhinometry, acoustic rhinometry, rhinomanometry and nasal peak flow to detect the decongestant effect of xylometazoline
  10. Effects of intranasal xylometazoline, alone or in combination with ipratropium, in patients with common cold
  11. Influence of intranasal sterile isotonic sea water applications on xylometazoline administration: An experimental study in pigs
  12. The value of Ems Mineral Salts in the treatment of rhinosinusitis in children: Prospective study on the efficacy of mineral salts versus xylometazoline in the topical nasal treatment of children
  13. Reversible cardiomyopathy due to chronic use of xylometazoline topical nasal spray
  14. Extractive spectrophotometric determination of chromium(III) in steels using 4-(2-pyridylazo)resorcinol and xylometazoline hydrochloride
  15. A Randomized Trial of 181 Patients to Topical Anesthesia with Lidocaine Versus Lidocaine Plus Xylometazoline for Unsedated Ultrathin Transnasal Upper Gastrointestinal Endoscopy
  16. Structure of xylometazoline (otrivin) hydrochloride, an α-adrenergic agonist
  17. Evaluation of the Effect of Xylometazoline on the Absorption of Zolmitriptan Nasal Spray
  18. Xylometazoline
  19. Xylometazoline
  20. Xylometazoline
  21. Xylometazoline
  22. Xylometazoline poisoning: A 40-fold nasal overdose caused by a compounding error in 3 children
  23. Xylometazoline overdose

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