Buy SeptaNazal spray 0.05 mg + 5 mg/dose 10 ml
  • Buy SeptaNazal spray 0.05 mg + 5 mg/dose 10 ml

Xylometazoline, Dexpanthenol

Krka dd Novo mesto AO
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Clinical Pharmacology

Xylometazoline - a local vasoconstrictor (decongestant) with alpha-adrenomimetic activity, causes a narrowing of the blood vessels of the nasal mucosa, restores the patency of the nasal passages, eliminates nasal congestion, and facilitates nasal breathing. The effect of xylometazoline usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol is a vitamin B group, a derivative of pantothenic acid.

Dexpanthenol is converted into pantothenic acid in the body, which is a component of coenzyme A (CoA), and participates in acetylation processes, carbohydrate and fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins, stimulates the regeneration of the skin and mucous membranes, normalizes cellular metabolism, accelerates mitosis, and accelerates mitosis. increases the strength of collagen fibers. It has a regenerating, metabolic and weak anti-inflammatory effect.


acute respiratory infections with rhinitis;

acute allergic rhinitis;

vasomotor rhinitis;


otitis media (as part of combination therapy to reduce swelling of the nasopharyngeal mucosa);

to facilitate rhinoscopy, restoration of disturbed nasal breathing after surgical interventions in the nasal cavity.

Xylometazoline, Dexpanthenol is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
SeptaNazal Krka dd Novo mesto AO Slovenia spray
Nasic Klosterfrau Berlin GmbH Germany spray

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Xylometazoline, Dexpanthenol

Dosage and Administration

Intranasal. One metered injection into each nasal passage 3-4 times a day.

Dosed nasal spray - for adults and children over 6 years old.

Spray for nasal use dosed for children - for children from 2 to 6 years.

Remove the protective cap before use. Before the first use of the spray or after a long break, it is necessary to press the pump dispenser several times until a uniform spraying appears.

Insert the tip of the bottle vertically in the nasal passage, take a slow breath through the nose, while simultaneously pressing the pump dispenser 1 time. Repeat the procedure in the other nasal passage. After application, the tip should be wiped with a paper napkin and closed with a protective cap. The duration of therapy is 3-5 days.

Adverse reactions

With frequent and / or long-term use: irritation and / or dryness of the nasal mucosa, burning, tingling, sneezing, hypersecretion, allergic reactions, swelling of the nasal mucosa, nausea, vomiting, headache, dry rhinitis, feeling of heartbeat, increased blood pressure, tachycardia, insomnia, blurred vision, depression (with prolonged use of high doses).


Common to both dosage forms:

hypersensitivity to any of the components of the drug;

arterial hypertension;


pronounced atherosclerosis;


atrophic rhinitis;


surgery on the meninges (in history);

prostatic hyperplasia;

simultaneous use with MAO inhibitors and tricyclic antidepressants;


breastfeeding period.

For spray for nasal use dosed additionally


children's age up to 6 years.

For nasal spray dosed for children additionally

dry rhinitis;

children's age up to 2 years.

Common to both dosage forms:

With caution: diabetes, pheochromocytoma, cardiovascular disease (including coronary heart disease, angina), hypersensitivity to the action of adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

  • Brand name: SeptaNazal
  • Active ingredient: Xylometazoline, Dexpanthenol
  • Dosage form: nasal spray
  • Manufacturer: Krka dd Novo mesto AO
  • Country of Origin: Slovenia

Studies and clinical trials of Xylometazoline, Dexpanthenol (Click to expand)

  1. F/A

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