Zorex®

Brand Valenta

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Clinical Pharmacology

Zorex has a detoxification (including with respect to the half-life products of ethyl alcohol, heavy metals and their compounds, arsenous compounds) action. The clinical studies have shown the hepatoprotective and antioxidant properties of unithiol.

The active sulfhydryl groups of unithiol, interacting with thiol poisons and alcohol (ethanol) half-life products found in blood and tissues, form with them non-toxic compounds (complexes) that are excreted in the urine.

When taking the drug inside, Unithiol penetrates the liver with portal blood flow, where it binds quickly and physiologically to acetaldehyde. Zorex activates alcohol dehydrogenase, enhancing the oxidation of ethanol and detoxifying its toxic agents with the enzyme system of the liver. The presence in the composition of the drug Zorex Calcium Pantothenate enhances the detoxification effect of Unithiol.

Indications

alcohol abuse;
alcohol withdrawal syndrome;
chronic alcoholism (as part of complex therapy);
acute and chronic poisoning with organic and inorganic compounds of arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony;
intoxication with cardiac glycosides.

Composition

1 caps contains unithiol (2,3-dimercaptopropanesulfonate sodium) 250 mg, calcium pantothenate 10 mg.

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Dosage and Administration

Inside 30 minutes before meals, without chewing, drinking water.

With the abuse of alcohol or alcohol withdrawal syndrome - 1 caps each. (250 mg + 10 mg) 1-2 times a day. If necessary, the daily dose can be increased to 1000 mg, and the dose rate can be increased to 3 times a day. The drug should be taken 3-7 days before the cessation of symptoms of intoxication.

In case of poisoning with arsenic compounds and heavy metal salts - 300–1000 mg / day, divided into 2-3 doses, for 7–10 days.

Adverse reactions

Allergic reactions: rarely - pruritus, urticaria, rash on the skin and mucous membranes, swelling of the mucous membranes, genital itching, stomatitis; very rarely - the appearance of an allergic reaction by the type of angioedema or Stephen-Johnson syndrome (sudden increase in body temperature, malaise, spotty-vesicular or bullous eruptions on the skin, mucous membranes of the oral cavity, genitals, in the anus). In this case, you should stop taking the drug and consult a doctor. The risk of allergic reactions is higher in individuals with bronchial asthma or a history of allergies.

When used in high doses: nausea, dizziness, tachycardia, pallor of the skin.

Contraindications

hypersensitivity to the drug;
severe decompensated diseases of the liver and kidneys.
Carefully: low blood pressure.

Drug interactions

Incompatible with drugs containing salts of heavy metals, as well as with alkalis (decomposes quickly).

Pregnancy and Lactation

Data on the use of the drug Zorex during pregnancy and lactation (breastfeeding) is not. In connection with the lack of necessary information, use during pregnancy and during breastfeeding is contraindicated.

Special instructions

Influence on ability to drive motor transport and control mechanisms

The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving and other vehicles, working with moving machinery, the work of the dispatcher and operator, etc.).

Overdosage

Manifestations of overdose may occur when the recommended dose is exceeded by more than 10 times.

Symptoms: dyspnea, hyperkinesis, lethargy, lethargy, stupor, short-term seizures.

Treatment: gastric lavage, the appointment of Activated charcoal, laxatives, symptomatic therapy, in acute cases - oxygen therapy, the introduction of dextrose, etc.