Zovirax Duo

Brand GlaxoSmithKline

In stock 1909 Items

Available since: 2019-09-19

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Clinical Pharmacology

Zovirax is an antiviral drug, a synthetic analogue of the purine nucleoside that has the ability to inhibit in vitro and in vivo replication of Herpes simplex type 1 and 2 viruses, Varicella zoster virus, Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In cell culture, acyclovir has the most pronounced antiviral activity against Herpes simplex type 1, then in order of decreasing activity follow: Herpes simplex type 2, Varicella zoster, EBV and CMV.

The effect of acyclovir on viruses is highly selective. Acyclovir is not a substrate for the thymidine kinase enzyme of uninfected cells; therefore, it is of low toxicity to mammalian cells. Thymidine kinase of cells infected with Herpes simplex type 1 and 2 viruses, Varicella zoster, EBV and CMV, turns acyclovir into acyclovir monophosphate, a nucleoside analogue, which is then sequentially converted to diphosphate and triphosphate under the action of cellular enzymes. The inclusion of acyclovir triphosphate in the chain of viral DNA and the subsequent chain termination block further replication of viral DNA.

In patients with severe immunodeficiency, prolonged or repeated courses of therapy with acyclovir can lead to the formation of resistant strains, and therefore further treatment with acyclovir may be ineffective. Most of the isolated strains with reduced sensitivity to acyclovir showed a relatively low content of viral thymidine kinase, a violation of the structure of viral thymidine kinase or DNA polymerase. The effect of acyclovir on strains of the Herpes simplex virus in vitro can also lead to the formation of less sensitive strains. The correlation between the sensitivity of Herpes simplex virus strains to acyclovir in vitro and the clinical efficacy of the drug has not been established.

It was shown that intravenous administration of Zovirax in high doses reduces the frequency of occurrence and retards the development of cytomegalovirus infection. If, after such infusion therapy, treatment with acyclovir is administered for oral administration in high doses for 6 months, then mortality and the incidence of viremia will decrease.

Indications

It has been shown that high doses of intravenous Zovirax reduce the frequency of occurrence and delay the development of CMV infection. If, after infusion therapy with Zovirax at a high dose, Zovirax is administered for oral administration at a high dose for 6 months, then mortality and the incidence of viremia are reduced.

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Dosage and Administration

Apply the preparation with a thin layer on the affected skin 5 times a day (every 4 hours), except for night time. The treatment duration is at least 5 days

Adverse reactions

Do not use the drug for more than 5 days. If symptoms persist, consult a doctor. Used Only for external use in adults and children over 12 years old. The cream can be applied ONLY WHEN THE HERPES SKIN LIP. Do not apply the drug to the mucous membranes of the mouth and eyes. Do not use for the treatment of genital herpes. Do not use the drug in patients with immunodeficiency, because they have a high risk of developing resistance to acyclovir

Contraindications

Hypersensitivity to acyclovir, valacyclovir, hydrocortisone and other components of the drug;
skin lesions caused by other viruses, fungal, bacterial skin diseases, and parasitic skin infections;
Skin tumors, rosacea, acne vulgaris, perioral dermatitis;
Children's age up to 12 years.

Special instructions

To achieve the maximum therapeutic effect and prevent the formation of blisters on the skin, it is necessary to begin using the drug when the first signs of the disease appear.