Propycil® [Propylthiouracil]
Haupt Pharma Berlin GmbH
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Clinical Pharmacology
It has a pronounced thyreostatic effect. Interferes with the process of iodination of thyroglobulin, reduces the formation of the active form of iodine in the thyroid gland, blocking the system of peroxidases. Inhibits the conversion of T4 to T3 by forming a reverse T3.
Indications
To avoid complications, use only after consulting a doctor.
Composition
| 1 tab. | |
| propylthiouracil | 50 mg |
| excipients: lactose monohydrate; corn starch; colloidal silicon dioxide; Povidone; gelatinized starch; magnesium stearate | |
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Dosage and Administration
Intramuscularly 5-10 mg once a day for 5-10 days.
Before the introduction of the drug is dissolved in 1 ml of a 0.25-0.5% solution of novocaine, sodium chloride solution of 0.9% or water for injection.
If necessary, repeat the course (after 1-6 months).
Adverse reactions
Allergic reactions.
Contraindications
Hypersensitivity.
Drug interactions
Clinically significant effects of the interaction of the drug Prostacor® with other drugs not identified.
Special instructions
Before use, it is recommended to consult with a specialist.
Overdosage
Cases of drug overdose Prostacor® are not described.
- Brand name: Propycil
- Active ingredient: Propylthiouracil
Studies and clinical trials of Propylthiouracil (Click to expand)
- Propylthiouracil-induced hypothyroidism reduces xenograft tumor growth in athymic nude mice
- Enhanced mineralization of the tibial epiphyseal plate in the rat following propylthiouracil treatment: A histochemical, light, and electron microscopic study
- Observations on the fine structure of propylthiouracil-induced “brown degeneration” in the zona reticularis of mouse adrenal cortex
- Neonatal hypothyroidism causes delayed sertoli cell maturation in rats treated with propylthiouracil: Evidence that the sertoli cell controls testis growth
- Apparent vasculitis associated with propylthiouracil use
- Dose-dependent induction of anti–native dna antibodies in cats by propylthiouracil
- Long-term effects of propylthiouracil-induced neonatal hypothyroidism
- Effects of propylthiouracil and methimazole on splanchnic hemodynamics in awake and unrestrained rats
- Effect of propylthiouracil on the ethanol-induced increase in liver oxygen consumption in awake rats
- Fulminant hepatic failure associated with propylthiouracil: A case report with treatment emphasis on the use of plasmapheresis
- Comparison of potential protective effects of melatonin, indole-3-propionic acid, and propylthiouracil against lipid peroxidation caused by potassium bromate in the thyroid gland
- Effect of hypothyroidism induced by propylthiouracil on ovarian function and structure in offspring from treated mothers (Rats)
- Growth of thyroid tissue in the gills of Amblystoma punctatum reared in propylthiouracil
- The effect of gonadectomy and propylthiouracil treatment on the submandibular gland of the Mongolian gerbil, Meriones unguiculatus
- Effect of hypothyroidism induced by propylthiouracil and thiourea on male and female reproductive systems of neonatal mice
- Synthesis and antiperoxidase activity of propylthiouracil derivatives and metabolites
- High-performance liquid chromatographic determination of plasma propylthiouracil
- High-pressure liquid chromatographic determination of propylthiouracil in human plasma
- Bioavailability of propylthiouracil in humans
- Effect of triiodothyronine, thyrotropin-releasing-hormone and propylthiouracil on the thermogenic capacities of Djungarian hamsters living in natural photoperiod
- Selective liquid chromatographic assay for propylthiouracil in plasma
- Silver electrode in direct potentiometric determination of propylthiouracil in pharmaceutical dosage form
- Determination of propylthiouracil and methylthiouracil in human serum using high-performance liquid chromatography with chemiluminescence detection
- Effect of n-propylthiouracil or thyroxine on arsenic trioxide toxicity in the liver of rat
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