Senna leaves
Krasnogorskleksredstva
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2019-09-19
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Clinical Pharmacology
Senna leaves - a laxative of plant origin. Senna leaves contain dianthron glycosides (about 3%) - sennosides A, A1, B-G; small amount of anthraquinone glycosides, incl. aloe-emodina and rein 8-glycosides; about 10% mucus; flavonoids, incl. camperol derivatives; naphthalene glycosides.
Stimulates colon motility, causes normal stools 8-10 hours after ingestion. Selectively acts on the colon, restores the normal functioning of the intestine, does not cause addiction and does not affect digestion.
Indications
Constipation due to hypotension and sluggish peristalsis of the colon. Regulation of stool with hemorrhoids, proctitis, anal fissures; spastic and atonic constipation of various etiologies.
Composition
Leaves of senna normifolia
Senna leaves is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Senna leaves | Krasnogorskleksredstva | Russia | Other |
| Senna leaves | Krasnogorskleksredstva | Russia | tea bags |
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Dosage and Administration
2 tablespoons of the leaves are placed in an enamel bowl, pour 200 ml (1 cup) of hot boiled water, cover with a lid and heat on a boiling water bath for 30 minutes, then incubate at room temperature until completely cooled, filter, squeeze the remaining raw material. The volume of the resulting broth is brought to 200 ml with boiled water. Administered orally on 1/2 glasses in the evening after food. The course of treatment is 2-3 weeks. Before using the broth is recommended to shake.
Adverse reactions
Maybe: flatulence, colicky abdominal pain.
With prolonged use, especially in high doses, - loss of electrolytes (mainly potassium), albuminuria and hematuria, deposition of melanin in the intestinal mucosa, damage to the intermuscular plexus.
Contraindications
- Hypersensitivity
- spastic constipation
- spastic colitis,
- acute inflammatory diseases of the abdominal organs,
- appendicitis,
- intestinal obstruction,
- strangulated hernia,
- perforated ulcer,
- proctitis and hemorrhoids (acute phase),
- abdominal pain of obscure origin,
- metrorrhage
- gastrointestinal bleeding,
- cystitis,
- violations of water and electrolyte metabolism,
- pregnancy.
Special instructions
Be wary when using diseases of the liver and / or kidneys. Can be used for preoperative patient preparation.
Studies and clinical trials of Senna leaves (Click to expand)
- Toxicity of Senna obtusifolia fresh and fermented leaves (kawal), Senna alata leaves and some products from Senna alata on rats
- A new spectrophotometric method of assay for alexandria senna leaves (Cassia acutifolia-Delile)
- A new fluorometric method of assay for alexandria senna leaves (Cassia acutifolia, delile)
- Comparison between high-performance thin-layer chromatography-flourometry and high-performance liquid chromatography for the determination of sennosides A and B in Senna (Cassia spp.) pods and leaves
- Seasonal variation in the content of sennoside in Senna leaves
- Structural characteristics, fluorescence quenching, and antioxidant activity of the arabinogalactan protein-rich fraction from senna (Cassia angustifolia) leaves
- Chemical composition of Indian senna leaves (Cassia angustifolia)
- Determination of anthraquinones in rhubarb roots, dock flowers and senna leaves by normal-phase high performance liquid chromatography
- Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats
- Palthé Senna As An Adulterant Of Indian Senna Leaves
- Quantitative HPLC Determination and Extraction of Anthraquinones in Senna alata Leaves
- URTICARIA DUE TO SENNA LEAVES
- Quantitative Analysis of Barakol Content in Senna siamea Leaves and Flowers by TLC-Densitometry
- Stability Control of Senna Leaves and Senna extracts
- Chemical Control of Yield of Sennosides in Senna Leaves
- ESTIMATION OF SENNOSIDES A, B, C AND D IN SENNA LEAVES, PODS AND FORMULATIONS
- Influence of the extracts of senna leaves, blackberries and hibiscus flowers in the oxidation reaction of commercial biodiesel
- Anti-nociceptive Effect of Methanol Extract of Leaves of Senna singueana in Mice
- Antibacterial-guided isolation of constituents from Senna alata leaves with a particular reference against Multi-Drug-Resistant Vibrio cholerae and Shigella flexneri
- Antifungal and antibacterial activities of an alcoholic extract of Senna alata leaves
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