Buy Ascoril pills 50 pcs
  • Buy Ascoril pills 50 pcs


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Clinical Pharmacology

Ascoril - bronchodilator, mucolytic, expectorant.


The combined drug has a bronchodilator, expectorant and mucolytic action.

Salbutamol - bronchodilator, stimulates beta2-adrenoreceptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases lung capacity. It causes the expansion of the coronary arteries, does not reduce blood pressure.

Bromhexine is a mucolytic agent, it has expectorant and antitussive action. Increases the serous component of bronchial secretions; activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves the discharge.

Guaifenesin - mucolytic agent, reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa, producing neutral polysaccharides, depolymerizes the acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition of non-productive cough into productive.



When ingestion absorption is high. Eating reduces the rate of absorption, but does not affect bioavailability. Communication with plasma proteins - 10%. Penetrates through the placenta. Subjected to presystemic metabolism in the liver and intestinal wall, is inactivated by phenol sulfotransferase to 4-o-sulfate ester. T1/2 - 3.8–6 hours. Excreted by the kidneys (69–90%), mainly as an inactive phenolsulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%.


When administered almost completely (99%) absorbed in the digestive tract within 30 minutes. Bioavailability is low (the effect of the primary passage through the liver). It penetrates the placental barrier and the BBB. In the liver it undergoes demethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T1/2 - 15 hours (due to slow reverse diffusion from tissues). Excreted by the kidneys. When CRF is impaired excretion of metabolites. With repeated use may accumulate.


Absorption from the gastrointestinal tract is fast (25–30 minutes after ingestion). T1/2 - 1 h. Penetrates into tissues containing acid mucopolysaccharides. Approximately 60% of the administered drug is metabolized in the liver. It is excreted by the lungs (with sputum) and kidneys, both unchanged and in the form of inactive metabolites.


  • bronchial asthma;
  • tracheobronchitis;
  • obstructive bronchitis;
  • pneumonia;
  • emphysema;
  • whooping cough;
  • pneumoconiosis;
  • pulmonary tuberculosis.


1 tablet contains:

Active substances: salbutamol - 2 mg, Bromhexine - 8 mg, guaifenesin - 100 mg;

Excipients: calcium phosphate; corn starch; methyl parahydroxybenzoate (methyl paraben); propyl parahydroxybenzoate (propyl paraben); purified talc; colloidal silicon dioxide; magnesium stearate.

Ascoril® is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Ascoril Glenmark India pills
Ascoril expectorant Glenmark India syrup

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Dosage and Administration

For oral use Adults and children over 12 years old - 1 tablet 3 times a day; children from 6 to 12 years - 1/2 or 1 tablet 3 times a day.

Children under 6 years old The use of Ascoril syrup is recommended.

Adverse reactions

Rarely when used in high doses: 

  • headache,
  • dizziness,
  • increased nervous irritability,
  • sleep disturbance,
  • drowsiness,
  • tremor,
  • convulsions
  • nausea,
  • vomiting
  • diarrhea,
  • exacerbation of gastric ulcer and duodenal ulcer,
  • cardiopalmus,
  • possible staining of urine in pink,
  • allergic reactions (rash, urticaria),
  • collapse,
  • bronchospasm.

Carefully: diabetes; peptic ulcer of the stomach and duodenum in remission.

Drug interactions

Other beta2α-adrenomimetic drugs and theophylline increase the effects of salbutamol and increase the likelihood of side effects.

Ascoril is not prescribed simultaneously with drugs containing codeine, and other antitussives, because this makes it difficult to discharge liquefied sputum.

Ascoril Bromhexine, which is part of the preparation, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into lung tissue.

Do not use the drug Ascoril concurrently with non-selective blockers of beta-adrenergic receptors, such as propranolol.

Part of the drug Ascoril salbutamol is not recommended for patients who receive MAO inhibitors.

Diuretics and drugs GKS enhance the hypokalemic effect of salbutamol.

It is not recommended to take alkaline drink along with Ascoril.

Pregnancy and Lactation

During pregnancy, the drug is not recommended.

If necessary, drug treatment during lactation breastfeeding should be discontinued.


Symptoms: increased side effects.

Treatment: symptomatic therapy.

  • Brand name: Ascoril
  • Active ingredient: Bromhexin, Guaifenezin, Salbutamol
  • Dosage form: Pills
  • Manufacturer: Glenmark
  • Country of Origin: India

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