Hydrogen peroxide
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2019-09-19
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Clinical Pharmacology
Antiseptic and oxidant groups, has a hemostatic effect. When hydrogen peroxide comes into contact with damaged skin and mucous membranes, active oxygen is released, and mechanical purification and inactivation of organic substances (proteins, blood, pus) occurs. The antiseptic effect of the drug is not sterilizing, with its use only a temporary decrease in the number of microorganisms occurs.
Indications
Treatment of purulent and bleeding wounds; stop capillary bleeding, etc. For washing and rinsing with stomatitis, tonsillitis, gynecological diseases.
Composition
Peroxide medical concentrated from 75 to 110 g
(depending on the actual hydrogen content of the peroxide in the initial preparation)
Sodium benzoate - 0.5 g
Purified water - up to 1000 ml
Hydrogen peroxide is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Hydrogen peroxide | vials | ||
| hydrogen-SOLOpharm | solution | ||
| Hydrogen peroxide | Rosbio | Russia | bottle |
| Hydrogen peroxide | Samaramedprom | Russia | vials |
| Hydrogen peroxide solution | Lekker Ltd | Russia | Other |
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Dosage and Administration
Damaged areas of the skin and mucous membranes are treated with a cotton or gauze pad moistened with hydrogen peroxide solution; contaminated wounds, ulcers are treated with a stream.
For treatment of mucous membranes in the form of washes and rinses, when rinsing the mouth and throat, the preparation is diluted with water to a concentration of 0.2-0.3% (1 tbsp per cup of water).
Adverse reactions
Perhaps a burning sensation in the treatment of wounds, in rare cases, allergic reactions.
Contraindications
Increased individual sensitivity.
Special instructions
It is not recommended to use the drug for dressings.
The drug should not be injected into the cavity.
Avoid getting the drug in the eyes (in case of contact - rinse with plenty of water)
The drug is unstable in an alkaline medium, in the presence of alkali metals, complex radicals, some oxidants, and also not in light and in heat.
3% solution is used internally as an antidote (combination with a 3% solution of acetic acid) in case of potassium poisoning with permanganate.
- Brand name: Hydrogen peroxide
- Active ingredient: Hydrogen peroxide
- Manufacturer: Merck Serono
Studies and clinical trials of Hydrogen peroxide (Click to expand)
- The cell wall stiffening mechanism inPinus pinaster Aiton: regulation by apoplastic levels of ascorbate and hydrogen peroxide
- Cytochemical demonstration of sites of hydrogen peroxide generation and increased vascular permeability in isolated pig hearts after ischaemia and reperfusion
- A comparative study of the purity, enzyme activity, and inactivation by hydrogen peroxide of commercially available horseradish peroxidase isoenzymes A and C
- Mechanism of oxygen availability from hydrogen peroxide to aerobic cultures of Xanthomonas campestris
- Single-cell measurement of superoxide anion and hydrogen peroxide production by human neutrophils with digital imaging fluorescence microscopy
- Delayed oligodendrocyte degeneration induced by brief exposure to hydrogen peroxide
- Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells
- PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase–amyloid complexes, amyloid25–35 fragment, glutamate, and hydrogen peroxide
- Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell death
- Kinetics and mechanism of hydrogen peroxide oxidation of chromone-3-carboxaldehydes in aqueous acid and micellar media
- Kinetic study of the oxidation of indigocarmine by hydrogen peroxide with ferrous and ferric ions in acid medium
- Kinetics of O·− and O3·− in alkaline aqueous solutions of hydrogen peroxide
- Reactivity of the bis[1-Hydroxy-2-(Salicylideneamino)Ethane]Manganese(II) complex toward hydrogen peroxide: Kinetics and intermediates of reaction
- Oxidation of manganese(II) by ozone and reduction of manganese(III) by hydrogen peroxide in acidic solution
- Kinetics of hydrogen peroxide decomposition with complexed and “free” iron catalysts
- Structural stabilities of water-soluble MnTDCSPP, MnTSPP, and supported analogues toward hydrogen peroxide and sodium hypochlorite
- Half-projected Hartree–Fock calculations for the spectroscopic parameters, frequencies, and intensities of the torsional mode of the lowest lying singlet excited states of hydrogen peroxide
- Hydrogen peroxide initiated grafting of acrylamide onto poly(ethylene terephthalate) fibers in benzyl alcohol
- Blend membrane of regenerated silk fibroin, poly(vinyl alcohol), and peroxidase and its application to a ferrocene-mediating hydrogen peroxide sensor
- Hydroxyl-terminated polybutadiene. I. A study of the polymerization of butadiene in the presence of hydrogen peroxide
- The kinetics and thermodynamics of nylon 6 fiber dyeing with hydrogen peroxide-glyoxal redox system
- Hydrogen peroxide toward enhanced oxide growth on titanium in PBS solution: Blue coloration and clinical relevance
- Bioactivity of titanium treated with hydrogen peroxide solutions containing metal chlorides
- Biocompatibility of potential wound management products: Hydrogen peroxide generation by fungal chitin/chitosans and their effects on the proliferation of murine L929 fibroblasts in culture
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