Octenisept® [Octenidine dihydrochloride]
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2019-09-19
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Clinical Pharmacology
Antiseptic.
It is active against gram-positive and gram-negative bacteria, lipophilic viruses (for example, the Herpes simplex virus and hepatitis B virus), as well as against yeast-like fungi and dermatophytes.
Indications
- treatment of skin and mucous membranes before diagnostic and operational activities in pediatric, surgical and obstetric and gynecological practice, in traumatology, proctology, dermatology, otolaryngology, dentistry;
- treatment of wound and burn surfaces;
- prevention of mycoses of feet and interdigital mycoses.
Composition
| Solution for local and external use | 100 ml |
| octenidine dihydrochloride | 0.1 g |
| phenoxyethanol | 2 g |
| excipients: cocamidopropyl betaine; sodium D-gluconate; glycerol 85%; sodium chloride; purified water |
Octenidine dihydrochloride is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Octenisept | Schülke and Mayr | Germany | spray |
| Octenisept | Schülke and Mayr | Germany | bottle |
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Dosage and Administration
Topically, locally.
The treatment is carried out alternately with two tampons abundantly moistened with Octenisept. The affected surface must be completely treated. On easily accessible areas of the drug can be applied by spraying. The exposure time is at least 1–2 minutes.
Dressings are applied after complete drying of Octenisept (ie, after 1–2 minutes). Before using the preparation, the tissue sections to be treated must be cleaned of pus or other biosubstrates.
20 ml of the preparation is used for rinsing the oral cavity, it is recommended to re-rinse after 20 s.
For the prevention of fungal diseases, the skin between the toes and feet is treated with the drug 2 times a day (morning and evening). Duration of treatment up to 14 days.
Adverse reactions
Perhaps a brief burning sensation at the site of application. When rinsing the mouth, a bitter taste is possible.
Contraindications
Hypersensitivity to the drug.
Drug interactions
Do not use with iodine-containing antiseptics.
Special instructions
In children's practice - without age restrictions.
Do not swallow. Not recommended for use on the eardrum.
- Brand name: Octenisept
- Active ingredient: Octenidine dihydrochloride
- Dosage form: Transparent solution, practically free from visible particles, with a weak specific smell.
- Manufacturer: Schülke and Mayr
Studies and clinical trials of Octenidine dihydrochloride (Click to expand)
- The percutaneous permeation of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) through skin of different speciesin vitro
- Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial
- Inhibition of intergeneric coaggregation among oral bacteria by cetylpyridinium chloride, chlorhexidine digluconate and octenidine dihydrochloride
- The effect of a combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept®) on wound healing in pigs in vivo and its in vitro percutaneous permeation through intact and barrier disrupted porcine skin
- Comparison of octenidine dihydrochloride (Octenisept®), polihexanide (Prontosan®) and povidon iodine (Betadine®) for topical antibacterial effects in Pseudomonas aeruginosa-contaminated, full-skin thickness burn wounds in rats
- Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review
- Questions linked to Krishna BVS, Gibb AP. Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review. J Hosp Infect 2009;74:201—205.
- Answers linked to Krishna BVS, Gibb AP. Use of octenidine dihydrochloride in meticillin-resistant Staphylococcus aureus decolonisation regimens: a literature review. J Hosp Infect 2009;74:201–205.
- The antimicrobial effect of Octenidine-dihydrochloride coated polymer tracheotomy tubes on Staphylococcus aureus and Pseudomonas aeruginosa colonisation
- Impact of antiseptics on radical metabolism, antioxidant status and genotoxic stress in blood cells: povidone-iodine versus octenidine dihydrochloride
- Methicillin-resistant Staphylococcus aureus whole-body decolonization among hospitalized patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride
- Short-term relative antibacterial effect of octenidine dihydrochloride on the oral microflora in orthodontically treated patients
- Comparison of the antibacterial effect of silver sulfadiazine 1%, mupirocin 2%, Acticoat and octenidine dihydrochloride in a full-thickness rat burn model contaminated with multi drug resistant Acinetobacter baumannii
- Biofilm inhibition by an experimental dental resin composite containing octenidine dihydrochloride
- Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds
- SP19-4 Octenidine dihydrochloride – Characteristics and clinical use
- Standardized comparison of antiseptic efficacy of triclosan, PVP-iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate
- Low-level exposure of MRSA to octenidine dihydrochloride does not select for resistance
- In vitro antiplaque activity of octenidine dihydrochloride (WIN 41464-2) against preformed plaques of selected oral plaque-forming microorganisms.
- Residual Antimicrobial Effect of Chlorhexidine Digluconate and Octenidine Dihydrochloride on Reconstructed Human Epidermis
- Treatment of Pseudomonas Nail Infections with 0.1% Octenidine Dihydrochloride Solution
- Microbiological Evaluation of Octenidine Dihydrochloride Mouth Rinse after 5 Days' Use in Orthodontic Patients
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