Tachocomb®

Brand Takeda GmbH

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Clinical Pharmacology

hemostatic agent.

ATX code: B02BC07.

Pharmacological properties

Pharmacodynamics.
Tachocomb^® is an absorbent hemostatic agent for local use.
Tachocomb^® consists of a collagen sponge coated on one side with components of fibrin glue (highly concentrated fibrinogen and thrombin), which promotes blood coagulation. Upon contact with a bleeding wound or other body fluids, coagulation factors contained in the covering layer are released and thrombin converts fibrinogen into fibrin.

Pharmacokinetics
In the body components of the sponge Tachocomb^® subjected to enzymatic cleavage within 3 to 6 weeks.
A special manufacturing and sterilization process ensures maximum safety of viruses and bacteria in the contents of the sponge.

Indications

Tachocomb^® it is usually indicated in cases where bleeding, as well as biliary, lymphatic, fluid and air fistulas cannot be controlled by traditional methods or when the expected results of these methods are insufficient
TACHOCOMB is used to achieve hemostasis and the “gluing” of tissues, especially during surgical interventions on parenchymal organs (for example, liver, spleen, pancreas, kidneys, lungs, adrenal glands and thyroid, lymph nodes). The drug can also be used to stop bleeding in surgical interventions in the field of ENT surgery, gynecology, urology, vascular surgery, traumatology, etc.
Tachocomb^® It can also be used for prophylactic purposes in the case of lymphatic, biliary and fluid fistulas.
Tachocomb^® can be used to create a tightness for surgical interventions on the lungs.

Composition

1 cm² sponge Tachocomb^® contains:
Active ingredients: fibrinogen 5.5 mg, thrombin 2 ME
Excipients: albumin, arginine hydrochloride, collagen, sodium chloride, sodium citrate, riboflavin.

Description
The sponge is almost white with a yellow coating on one side.

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Dosage and Administration

Tachocomb^® should be applied to surgical wound surfaces under sterile conditions.
Before applying the sponge Tachocomb^®and the wound surface should be as clean as possible (for example, from blood, disinfectants and other fluids).
The side covered with coagulation factors and marked in yellow color, put on the wound surface and press for 3-5 minutes. When applying sponge Tachocomb^®and on sufficiently wet wound surfaces, no additional moistening of the sponge is required. In the case of
Tachocomb^®and on dry wound surfaces, the sponge should be moistened with saline to achieve a complete connection with the dry areas of the wound surface.
Moisturized sponge Tachocomb^®and should be used immediately!
The size and number of sponge Tachocomb^®and depend on the size of the wound surface. The edges of the wound should be covered with a sponge for 1-2 cm. If more than one sponge is required to close the wound surface, then when applying it to the wound their edges should overlap each other. Using sterile scissors, you can cut out sponges of the required size both before and after application to the wound surface. Unused sponge fragments must be destroyed.

Adverse reactions

Possible increase in body temperature.

Contraindications

Hypersensitivity to Tachocomb Sponge Components^®.

Drug interactions

Interaction with other drugs is not installed.

Overdosage

There are no reports of overdose cases. Since the content of active ingredients is very small, overdose incidence when applying
Tachocomb^®but virtually impossible.