Aminocaproic acid

Aminocaproic acid solution is administered intravenously.

For adults, the drug is administered intravenously in the form of a 5% solution in an amount up to 100 ml drip at a rate of 50-60 drops per minute (for 15-30 minutes). During the first hour it is recommended to inject 4–5 g (80–100 ml) of the preparation, and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until the bleeding stops. In the case of continuing or re-bleeding injection of a 5% solution of aminocaproic acid, repeat every 4 hours.

The introduction of aminocaproic acid solution can be combined with the infusion of glucose solution, hydrolysates and antishock solutions. In acute fibrinolysis, when the content of fibrinogen in the blood drops sharply, the administration of aminocaproic acid must be supplemented with a subsequent infusion of fibrinogen.

Adverse reactions

• dizziness;
• headache;
• noise in ears,
• nausea;
• diarrhea;
• nasal congestion;
• skin rash;
• decrease in blood pressure;
• orthostatic hypotension;
• convulsions;
• rhabdomyolysis;
• myoglobinuria;
• acute renal failure;
• subendocardial hemorrhage.

Contraindications

With caution: 

• hypotension;
• valvular heart disease;
• failure;
• CKD

Drug interactions

It can be combined with the introduction of hydrolysates, glucose solutions (solutions of dextrose), antishock solutions. In acute fibrinolysis, the administration of aminocaproic acid with a fibrinogen content of 2-4 g (maximum - 8 g) must be supplemented with a subsequent infusion.

Antiaggregate reduction while taking direct and indirect anticoagulants.

No drugs should be added to the aminocaproic acid solution.

Pregnancy and Lactation

Special instructions

Overdosage