Buy Metindol Retard pills 75 mg, 50 pcs
  • Buy Metindol Retard pills 75 mg, 50 pcs

Indomethacin

AiCn Polfa Rzeszow
1338 Items
2019-09-19
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$23.45
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Clinical Pharmacology

Metindol Retard has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action of the drug is associated with inhibition of the activity of the enzyme cyclooxygenase and a decrease in the synthesis of prostaglandins, causing the appearance of pain, an increase in temperature and an increase in tissue permeability in the inflammatory focus.

In articular syndrome, Methindol retard reduces inflammation and relieves pain at rest and on movement, reduces morning stiffness and swelling of joints, and contributes to an increase in the range of motion.

Indications

  • rheumatic diseases
  • collagenoses,
  • radiculitis,
  • peripheral neuritis,
  • discopathy
  • gout (aggravation),
  • acute pain syndromes of radicular origin.

Composition

In 1 tablet of the prolonged action contains:

Active ingredient: indomethacin 75 mg.

Excipients:

  • microcrystalline cellulose,
  • potato starch,
  • methacrylic acid copolymer,
  • talc,
  • magnesium stearate.

Indomethacin is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Metindol Retard AiCn Polfa Rzeszow Poland pills
Indomethacin VetProm AD Bulgaria ointment
Indomethacin Biosynthesis Russia rectal suppositories
Indomethacin Biosynthesis Russia ointment
Indomethacin Berlin-Chemie/Menarini Germany rectal suppositories
Indometacin-Altfarm Altfarm Russia rectal suppositories
Indowallier Valeant Russia eye drops
Indomethacin Sopharma Bulgaria ointment
Indomethacin Sopharma Bulgaria rectal suppositories

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Indomethacin

Dosage and Administration

Metindol retard is taken orally, without chewing, during or immediately after a meal, drinking plenty of water or milk.

Adults: 1 or 2 pills per day, depending on the severity of the disease and individual sensitivity.

Do not exceed the dose of more than 150 mg per day.

Adverse reactions

  • dyspeptic disorders
  • gastrointestinal bleeding,
  • anorexia,
  • recurrence of gastric ulcer and duodenal ulcer,
  • headaches,
  • dizziness,
  • confusion,
  • convulsions
  • hypertension
  • swelling.

Contraindications

  • hypersensitivity
  • peptic ulcer and duodenal ulcer,
  • enteritis,
  • enterocolitis,
  • bronchial asthma,
  • children's age (up to 14 years).

Drug interactions

Increases plasma concentration of digoxin, methotrexate and lithium preparations, which can lead to increased toxicity.

Ethanol, colchicine, corticosteroids and corticotropin increase the risk of gastrointestinal bleeding.

Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs; increases the effects of indirect anticoagulants, antiplatelet agents, thrombolytics (alteplazy, streptokinase and urokinase) - there is a risk of bleeding.

Reduces the effect of diuretics, with the use of potassium-sparing diuretics increases the risk of hyperkalemia; reduces the effectiveness of uricosuric and antihypertensive drugs (including beta-blockers); enhances the side effects of glucocorticosteroids, acetylsalicylic acid, estrogen, other NSAIDs.

Cyclosporine and gold preparations increase nephrotoxicity (obviously, due to the suppression of the synthesis of prostaglandins in the kidneys).

Cefamendol, cefaperazon, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia and the risk of bleeding.

Antacids and colestyramine reduce the absorption of indomethacin.

Enhances the toxicity of zidovudine (due to inhibition of metabolism); in newborns, it increases the risk of toxic effects of aminoglycosides (because it reduces renal clearance and increases blood concentration).

Simultaneous use with serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Myelotoxic drugs increase the hematotoxicity of the drug.

Combined use with paracetamol increases the risk of nephrotoxic effects.

Pregnancy and Lactation

Contraindicated.

Special instructions

During treatment, control of the pattern of peripheral blood and the functional state of the liver and kidneys is necessary.

If necessary, determine the 17-ketosteroids drug should be canceled 48 hours before the study.

For the prevention and reduction of dyspeptic symptoms, antacid drugs should be used.

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Overdosage

Symptoms: nausea, vomiting, severe headache, dizziness, memory impairment and disorientation. In more severe cases, paresthesias, numbness of the extremities and convulsions are observed.

Treatment: consists in the rapid elimination of the drug from the body and the use of appropriate symptomatic agents. Indomethacin cannot be removed from the body through hemodialysis.

  • Brand name: Metindol Retard
  • Active ingredient: Indomethacin
  • Dosage form: Pills
  • Manufacturer: AiCn Polfa Rzeszow
  • Country of Origin: Poland

Studies and clinical trials of Indomethacin (Click to expand)

  1. Use of indomethacin in Langerhans cell histiocytosis
  2. Teratogen update: Fetal effects of indomethacin administration during pregnancy
  3. Effect of indomethacin suppositories on rectal polyposis in patients with familial adenomatous polyposis
  4. Effects of chronic indomethacin therapy on the development and progression of spontaneous mammary tumors in C3H/HEJ mice
  5. Effect of indomethacin on tumorigenicity and immunity induction in a murine model of mammary carcinoma
  6. Indomethacin release behaviors from pH and thermoresponsive poly(vinyl alcohol) and poly(acrylic acid) IPN hydrogels for site-specific drug delivery
  7. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light–induced skin carcinogenesis
  8. Baseline risk of gastrointestinal disorders among new users of meloxicam, ibuprofen, diclofenac, naproxen and indomethacin
  9. Preconcentration and Voltammetric Determination of Indomethacin at Carbon Paste Electrodes
  10. Anti-lymphoma effect of naproxen and indomethacin in a patient with relapsed diffuse large B-cell lymphoma
  11. Antipyretic effect of indomethacin in patients with malignancy
  12. Indomethacin-mediated enhancement of lymphocyte response to mitogens in healthy subjects and lung cancer patients
  13. A study of prostaglandin E2, parathormone, and response to indomethacin in patients with hypercalcemia of malignancy
  14. Indomethacin sensitive suppressor cell activity in head and neck cancer patients pre- and postirradiation therapy
  15. Antipyretic effects of indomethacin in liver metastases of solid tumors
  16. Prevention of colon polyposis and carcinomas by right hemicolectomy and indomethacin in animal model
  17. Further studies on the therapeutic effect of indomethacin on esophageal tumors
  18. Endoperoxidation, hyperprostaglandinemia, and hyperlipidemia in a case of erythrophagocytic lymphohistiocytosis. Reversal with VP-16 and indomethacin
  19. The use of indomethacin, sulindac, and tamoxifen for the treatment of desmoid tumors associated with familial polyposis
  20. Indomethacin sensitive suppressor-cell activity in head and neck cancer patients: The role of the adherent mononuclear cell
  21. Lipoperoxidation and T-cell leukemia of childhood. Effects of indomethacin
  22. Additive effect of indomethacin and methotrexate on suppression of growth in rats
  23. Effect of liposomes on the rate of alkaline hydrolysis of indomethacin and acemetacin

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