Dipyridamole

Brand Obolensky OP

In stock 1309 Items

Available since: 2019-09-19

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Clinical Pharmacology

Pharmacotherapeutic group: vasodilating agent

Pharmacological action: Dipyridamole has a inhibitory effect on platelet aggregation, improves microcirculation. It has a vasodilating effect.

As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases the decreased production of interferon alpha (a) and gamma (g) by white blood cells in vitro.

Dipyridamol increases non-specific antiviral resistance to viral infections.

Pharmacokinetics: The maximum plasma concentration of dipyridamole is achieved within 1 hour after ingestion. Dipyridamole is almost completely bound to blood proteins. The accumulation of dipyridamole occurs in myocardiocytes and in erythrocytes. Dipyridamole is metabolized in the liver by binding to glucuronic acid. The half-life is 20-30 minutes in the first phase, in the second phase - about 10 hours. Cumulation is possible (mainly in patients with impaired liver function). Excreted in the bile as monoglucuronide.

Indications

Treatment and prevention of cerebral circulatory disorders of ischemic type, dyscirculatory encephalopathy.

Prevention of arterial and venous thrombosis and their complications, prevention of thromboembolism after the operation of prosthetic heart valves.

Prevention of placental insufficiency in complicated pregnancy.

As part of complex therapy for any violations of microcirculation.

As an interferon inducer and immunomodulator for the prevention and treatment of influenza, ARVI.

Composition

1 coated tablet contains:

active substance: dipyridamole 25, 50 or 75 mg; Auxiliary components: milk sugar (lactose), Kollidon VA64 (copolyvidone), magnesium stearate, microcrystalline cellulose, sodium croscarmelose (primelloza), hydroxypropylmethylcellulose (hypromellose), talc (colloidal silicon dioxide), titanium dioxide, 80-ti-80, titan-80; yellow E104.

Dipyridamole is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Dipyridamole-FPO	Obolensky OP	Russia	pills
Curantyl®	Berlin-Chemie/Menarini	Germany	pills

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Dosage and Administration

Unless otherwise prescribed by a doctor, the following dosing regimens are recommended:

To reduce platelet aggregation, it is recommended to use Dipiridimol in a dose of 75-225 mg / day in several doses. In severe cases, the dose may be increased to 600 mg / day.

For the prevention of thromboembolic syndrome, stent thrombosis and coronary artery bypass grafts - 50 mg along with ASA on the first day, then 100 mg, followed by 4 times a day (canceled 7 days after the operation, subject to continued administration of ASK 325 mg / day) or 100 mg 4 times a day for 2 days before surgery and 100 mg 1 hour after surgery (if necessary in combination with warfarin).

For the prevention of influenza and other acute respiratory diseases, especially during epidemics, take the following scheme: 50 mg / day 1 time in 7 days for 4-5 weeks.

For the prevention of relapses in patients with frequent respiratory viral infections, Dipyridamole is recommended to be taken as follows: 100 mg / day (2 times 50 mg with an interval of 2 hours) once a week for 8-10 weeks.

Dipyridamole is recommended to take on an empty stomach, without chewing the pills, coated, washing down with a small amount of liquid.

Adverse reactions

Palpitations, bradycardia, thrombocytopenia, changes in the functional properties of platelets, bleeding, feeling of ear congestion, noise in the head, arthritis. Vomiting, diarrhea, epigastric pain, as well as such symptoms as weakness, dizziness, nausea, headache, myalgia, rhinitis may occur. Usually these side effects disappear with long-term use of dipyridamole.

As a result of the potential vasodilating action, high-dose dipyridamole may cause arterial hypotension, hot flashes and tachycardia, coronary robbery (at doses of more than 225 mg per day).

Hypersensitivity reactions of rash or urticaria are possible.

If you experience side effects, you must inform your doctor.

Contraindications

· Acute myocardial infarction, unstable angina, common stenosing atherosclerosis of the coronary arteries.

· Subaortic aortic stenosis

· Decompensated heart failure

· Hypertrophic obstructive cardiomyopathy

· Arterial hypotension and hypertension

· Severe heart rhythm disturbances

· Hemorrhagic diathesis

· Diseases with a tendency to bleed (gastric ulcer and duodenal ulcer, etc.)

· Chronic obstructive pulmonary disease

· Hepatic and / or renal failure

· Hypersensitivity to the drug.

With care Lactation period, children age (up to 12 years old - lack of sufficient experience).

Drug interactions

Xanthine derivatives (coffee, tea) can weaken the vasodilator and antithrombotic action of dipyridamole. The use of Dipyridamole with both direct and indirect anticoagulants (heparin) and thrombolytic agents or acetylsalicylic acid increases the risk of hemorrhagic complications, which must be considered when sharing.

Dipyridamole may enhance the effect of antihypertensive drugs.

Dipyridamole may impair the anticholinergic properties of cholinesterase inhibitors.

The antiaggregative effect is enhanced when taking antibiotics of cephalosporins (cefemandol, cefeperazone, cephatetan), penicillin antibiotics, tetracyclines, chloramphenicol, beta lactams, nicotinic acid.

Antacids reduce the maximum concentration due to decreased absorption.

Special instructions

To reduce dyspeptic phenomena taken with milk.
During treatment, you should avoid the use of natural coffee and tea, weakening the effect of dipyri-damola.
In coronary robbery syndrome, aminophylline is indicated to improve intracardiac blood flow.