Nystatin
Biochemist Saransk
825 Items
2019-09-19
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Clinical Pharmacology
Nystatin is a polyene antifungal antibiotic highly active against yeast-like fungi of the genus Candida. It has a fungicidal effect. The structure of the antibiotic has a large number of double bonds with a high tropism for the sterol structures of the cytoplasmic membrane of fungi, which contributes to the incorporation of the drug molecule into the cell membrane and the formation of a large number of channels through which the electrolytes are transported uncontrolled. An increase in osmolarity inside the cell leads to its death.
Indications
Nystatin ointment is used for candidiasis of the skin and mucous membranes.
Composition
1 g ointment contains:
Active substance: Nystatin 100,000 U; Excipients: anhydrous lanolin; petrolatum medical;
Nystatin is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Nystatin | Biochemist Saransk | Russia | ointment |
| Nystatin | Biosynthesis | Russia | rectal suppositories |
| Nystatin | Biosynthesis | Russia | ointment |
| Nystatin | Belmedpreparaty | Belarus | pills |
| Nystatin | Biosynthesis | Russia | suppositories |
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Dosage and Administration
Locally Apply a thin layer of ointment to the affected areas of the skin and mucous membranes 1–2 times a day, daily for 7–10 days. Can be combined with taking the drug inside.
Adverse reactions
Nausea, vomiting, diarrhea, sometimes fever, chills. Possible risk of spreading resistant forms of fungi (requires discontinuation of the drug).
Hypersensitivity.
Drug interactions
With the simultaneous use of nystatin with clotrimazole, the activity of the latter is reduced.
Pregnancy and Lactation
The appointment of Nystatin during pregnancy is possible if the intended benefit to the mother outweighs the potential risk to the fetus. Although the drug is absorbed in small quantities, it is not known whether it is excreted in breast milk, so if necessary, the appointment of Nystatin during lactation should decide whether to stop breastfeeding.
Special instructions
In cases of fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During treatment, sexual intercourse should be avoided.
Do not allow ointment to get into eyes. In case of accidental contact with eyes, rinse with plenty of water.
Do not use the ointment for tuberculosis, viral skin lesions, as well as staphylococcal pyoderma.
- Brand name: Nystatin
- Active ingredient: Nystatin
- Dosage form: Ointment
- Manufacturer: Biochemist Saransk
- Country of Origin: Russia
Studies and clinical trials of Nystatin (Click to expand)
- Nystatin—dextran conjugates: Synthesis and characterization
- Application of an airlift bioreactor to the nystatin biosynthesis
- Untersuchung der Stabilität von Nystatin und Natamycin mit Hilfe der UV-Spektrophotometrie
- Kinetics of growth and accumulation of aflatoxin B1 by Aspergillus parasiticus in the presence of butylated hydroxyanisole, isoprothiolane, and nystatin
- The structural elucidation of polyene macrolide antibiotics by mass spectrometry. Nystatin, amphotericin B and pimaricin
- Stereocontrolled Synthesis of the C21–C38 Fragment of the Unnatural Enantiomer of the Antibiotic Nystatin A1
- ChemInform Abstract: Enantioselective Polyol Synthesis via the Cope Rearrangement of Chiral Aldol Products. A Synthesis of the C1—C10-Fragment of Nystatin A1.
- ChemInform Abstract: Approaching the C33—C38 Fragments of Amphotericin B and Nystatin by a Retro-[1,4]-Brook Rearrangement and the Stereoselective Manipulation of the Resulting Allylsilane.
- ChemInform Abstract: First Stereocontrolled Synthesis of the (3S,5R,7R,10R,11R)-C1—C13 Fragment of Nystatin A1.
- Structure of Nystatin A2.
- Two examples of rapid and simple drug analysis in pharmaceutical formulations using capillary electrophoresis: Naphazoline, dexamethasone and benzalkonium in nose drops and nystatin in an oily suspension
- Use of nystatin for random spore selection in the yeast Saccharomycopsis lipolytica
- Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core–corona interface
- Development and in vitro evaluation of a mucoadhesive vaginal delivery system for nystatin
- Colorimetric assay of nystatin
- Evaluation of nystatin stability using tristimulus colorimetry
- Densitometric determination of zinc bacitracin and nystatin in animal feed
- Micellar electrokinetic capillary chromatography determination of zinc bacitracin and nystatin in animal feed
- Theoretical study of the CC stretching vibrations in linked polyene chains: Nystatin
- High-performance liquid chromatographic separations of nystatin and their influence on the antifungal activity
- Binding at lipid surfaces: Nystatin
- Nonsterol related resistance in Ustilago maydis to the polyene antifungals, amphotericin B and nystatin
- Synthesis of the C1C10 fragment of the macrolide antibiotic Nystatin A1 from a chiral building block obtained via chemoenzymatic approach
- Interaction between nystatin and natural membrane lipids in Langmuir monolayers—The role of a phospholipid in the mechanism of polyenes mode of action
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