Odeston® [Hymekromone]

Brand Polfa

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Clinical Pharmacology

Choleretic drug. Increases the formation and secretion of bile. It has a selective antispasmodic effect on the bile ducts and the sphincter of Oddi. The drug does not reduce gastrointestinal peristalsis and blood pressure.

Reduces the stagnation of bile, prevents the crystallization of cholesterol and, thereby, the development of cholelithiasis.

Pharmacokinetics

Suction and distribution

After ingestion is rapidly absorbed from the gastrointestinal tract. Cmax in the blood after ingestion is achieved after 2-3 hours. It is poorly bound to plasma proteins.

Removal

T1 / 2 is about 1 hour. Excreted in the urine: about 93% - as glucuronate, 1.4% - as sulfonate, 0.3% - unchanged.

Indications

biliary dyskinesia and Oddi's sphincter hyperkinetic type;
non-calculous chronic cholecystitis, cholangitis, cholelithiasis;
condition after surgery on the gallbladder and biliary tract;
loss of appetite, nausea, constipation, vomiting (on the background of bile hyposecretion).

Composition

pills from white to white with a yellowish shade of color, round, flat-cylindrical, with a chamfer and engraved on one side with the letters "Ch".

1 tab .:

Hymecromone 200 mg

Excipients: potato starch - 45 mg, gelatin - 3 mg, sodium lauryl sulfate - 1 mg, magnesium stearate - 1 mg.

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Dosage and Administration

The drug is administered orally for 30 minutes before eating.

Adults appoint 200-400 mg 3 times / day. The daily dose is 1200 mg. The course of treatment is 2 weeks.

In case of missing a dose, you must take the drug as soon as possible. If the time of the next intake is approaching, you should not take the missed dose. You should not take a double dose of the drug in order to compensate for the missed.

Adverse reactions

On the part of the digestive system: diarrhea, flatulence, abdominal pain, ulceration of the gastrointestinal mucosa.

Other: allergic reactions, headache.

Contraindications

hypersensitivity;
obstruction of the biliary tract;
renal / hepatic impairment;
ulcerative colitis, Crohn's disease;
stomach ulcer and duodenal ulcer;
hemophilia;
children's age up to 18 years.

Drug interactions

With simultaneous use of morphine, causing spasm of the sphincter of Oddi, weakens the effect of Odeston.

At simultaneous use of Odeston with metoclopramide, mutual weakening of action is noted.

Odeston enhances the effects of indirect anticoagulants.

Pregnancy and Lactation

There are no data on the safety of gimecromone during pregnancy and lactation.

Appointment Odestona during pregnancy and lactation (breastfeeding) is permissible only in cases where the intended benefits to the mother outweigh the potential risk to the fetus or child.

Special instructions

Special precautions when disposing of unused medication

Do not throw medicines into sewers or into household waste containers. For information on how to dispose of an unused drug, please contact your pharmacist. These activities will help protect the environment.

Influence on ability to drive motor transport and control mechanisms

The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require high concentration of attention and speed of psychomotor reactions.