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Orotic acid

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Clinical Pharmacology

Non-hormonal anabolic agent. It has a general stimulating effect on metabolic processes. It stimulates the synthesis of nucleic acids involved in protein synthesis, enhances reparative and regenerative processes in tissues. Orotic acid enhances the formation of albumin in the liver, especially in conditions of prolonged hypoxia, which occurs in certain diseases, such as heart failure. Improves the tolerance of cardiac glycosides, increases urine output.

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Orotic acid
Should be taken orally 1 hour before meals or 4 hours after meals. Adults 250-500 mg 2-3 times a day. The course of treatment lasts an average of 20-30 days. If necessary, the treatment can be repeated after 1 month. In exceptional cases, the adult dose can be increased to 3 g per day. Children - 10-20 mg / kg of body weight per day, divided into 3-4 doses (for example, if the child's body weight is 25 kg, then the permitted dose is from 25 x 10 = 250 mg (1/2 tab.) To 25 x 20 = 500 mg (1 tablet per day, divided into 3-4 doses.) The course of treatment is 3-5 weeks. If symptoms persist, consult your doctor.
  • Active ingredient: Orotic acid

Studies and clinical trials of Orotic acid (Click to expand)

  1. Vibrational analysis and spectra of orotic acid
  2. The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo
  3. Organometallic Complexes of Uracil and Orotic Acid Derivatives: Coordination Mode, Structure, and Reactivity
  4. Radioautographic comparison of RNA synthesis patterns in the epithelial cells of mouse pyloric antrum following 3H-uridine and 3H-orotic acid injections
  5. Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo-dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements
  6. Preparation of Orotic Acid from 4-Chloromethyluracil
  7. Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo-dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements
  8. Effect of orotic acid as a nucleating agent on the crystallization of bacterial poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers
  9. Nucleation mechanism of polyhydroxybutyrate and poly(hydroxybutyrate-co-hydroxyhexanoate) crystallized by orotic acid as a nucleating agent
  10. Positive selection for Dictyostelium mutants lacking uridine monophosphate synthase activity based on resistance to 5-fluoro-orotic acid
  11. Synthesis and Characterization of a Series of Lanthanide Complexes Constructed from Orotic Acid
  12. Differential pulse polarographic investigation of the nickel(II)–orotic acid complex
  13. Covalent binding of 4-dimethylaminophenylazo-3H-benzene (butter yellow) metabolites with liver ribosomal RNA: The dissociation of the binding mechanism from the orotic acid incorporating system
  14. Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells
  15. Preparative biosynthesis of 14C-orotic acid
  16. Orotic acid quantification in dried blood spots and biological fluids by hydrophilic interaction liquid chromatography tandem mass spectrometry
  17. Derivatives of orotic acid as potential reagents for the alkali metals
  18. Radioassay of orotic acid phosphoribosyltransferase and orotidylate decarboxylase utilizing a high-voltage paper electrophoresis technique or an improved 14CO2-release method
  19. Polarography of 5-nitro-orotic acid
  20. Effect of orotic acid and cholesterol on the synthesis and composition of chicken (Gallus domesticus) serum lipoproteins
  21. Variation of incorporation of [3H]orotic acid into the nucleotide and RNA fractions of different parts of the same liver lobe in the rat
  22. The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart
  23. Assessment of the capabilities of capillary zone electrophoresis for the determination of hippuric and orotic acid in whey

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