Sodium heparin
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2019-09-19
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Clinical Pharmacology
Anticoagulant of direct action, belongs to the group of middle molecular heparins. When applied externally, it has a local antithrombotic, antiexudative, moderate anti-inflammatory effect. It blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of blood. Gradually released from the ointment and passing through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the resorption of hematomas and blood clots and reduce swelling of tissues.
Indications
Prevention and treatment of superficial vein thrombophlebitis, post-injection and post-infusion phlebitis, hemorrhoids (including postpartum), elephantiasis, superficial parapleitis, lymphangitis, superficial mastitis, localized infiltrates and edemas, injuries and bruises (including muscle tissue, tendons) , joints), subcutaneous hematoma.
Composition
active ingredient: heparin sodium -1000 ME;
excipients: carbomer (carbopol 980 NF) - 11.0 mg, levomenthol - 0.5 mg, methyl parahydroxybenzoate - 1.5 mg, propyl parahydroxybenzoate - 0.5 mg, ethanol - 100.0 mg, Trolamine (triethanolamine) - to obtain pH from 5.5 to 7.5, purified water - up to 1 g.
Sodium heparin is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Trombogel | gel | ||
| Heparin | Slavic pharmacy | Russia | ampoules |
| Lioton 1000 | Berlin-Chemie/Menarini | Germany | gel |
| Heparin Sodium Brown | B. Brown Medical AG | Germany | Other |
| Heparin | Belmedpreparaty | Belarus | vials |
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Dosage and Administration
With thrombophlebitis Heparin ointment is applied with a thin layer (0.5 -1.0 g to the area with a diameter of 3-5 cm) 2-3 times a day and gently rubbed into the skin.
With thrombosis of hemorrhoidal veins The ointment is applied to a linen or bandage pad, which is applied to hemorrhoids and fixed with a bandage. With the same purpose, you can use a tampon soaked with heparin ointment, which is injected into the anus.
The ointment is used 2-3 times a day every day until the disappearance of inflammatory events, on average from 3 to 14 days.
Adverse reactions
Locally: redness, pruritus.
Contraindications
Ulcerative-necrotic processes in the zone of thrombophlebitis.
Pregnancy and Lactation
Use during pregnancy is possible only under strict indications. It can be used during breastfeeding, since there is no information about the penetration of heparin into breast milk.
Special instructions
Ointment should not be applied to open purulent wounds.
- Brand name: Trombogel
- Active ingredient: Sodium heparin
- Manufacturer: G.L.Farma GmbH
Studies and clinical trials of Sodium heparin (Click to expand)
- Prospective evaluation of bone density in pregnant women receiving the low molecular weight heparin enoxaparin sodium
- Small doses of subcutaneous sodium heparin in the prevention of deep vein thrombosis after elective hip operations
- Salvage late plasmapheresis in a patient with pulmonary embolism caused by heparin-induced thrombocytopenia primarily resistant to danaparoid sodium and lepirudin
- Sodium heparin determination: Comparison of an instrumental method with the USP method
- Molecular weight determination of commercial heparin sodium USP and its sterile solutions
- Intravenous toxicity of heparin-sodium sulfapyridine combinations and protective action of barbiturates
- The ultraviolet absorption of heparin sodium
- Affinity adsorption of human vitamin K-dependent coagulation factor IX onto heparin-like poly (styrene sodium sulfonate) adsorbent
- Hydrophilic surface coatings with embedded biocidal silver nanoparticles and sodium heparin for central venous catheters
- Heparin sodium compliance to the new proposed USP monograph: Elucidation of a minor structural modification responsible for a process dependent 2.10 ppm NMR signal
- Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium
- Effect of 3.2 vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low molecular weight heparin
- Compatibility of tirofiban HCl with dopamine HCl, famotidine, sodium heparin, lidocaine HCl and potassium chloride during simulated Y-site administration
- Lack of antimicrobial activity of sodium heparin for treating experimental catheter-related infection due to Staphylococcus aureus using the antibiotic-lock technique
- Sodium hydroxide permethylation of heparin disaccharides
- Errors due to heparin in the estimation of plasma sodium and potassium concentrations
- On the efficacy of low dose prednisolone and heparin sodium in the prevention of infusion thrombophlebitis. A double-blind trial
- Sodium deoxycholate promotes the absorption of heparin administered orally, probably by acting on gastrointestinal mucosa, in rats
- Evaluation of the oral absorption of heparin conjugated with sodium deoxycholate as a facilitating agent in GI tract
- Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin
- Intraoperative infusion of epoprostenol sodium for patients with heparin-induced thrombocytopenia undergoing cardiac surgery
- Effect of calcium/sodium heparin and heparin fractions on some functions of human polymor phonuclear receptors
- Heparin interference in whole blood sodium measurements in a pediatric setting
- Analysis of heparin sodium by SAX/HPLC for contaminants and impurities
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