Remaxol
Polysan
1402 Items
2019-09-19
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Clinical Pharmacology
REMAXOL® - balanced infusion solution with hepatoprotective effect.
The drug accelerates the transition of anaerobic processes to aerobic, improves the energy supply of hepatocytes, increases the synthesis of macroergs, increases the resistance of hepatocyte membranes to lipid peroxidation, restores the activity of antioxidant enzymes.
REMAXOL® reduces cytolysis, which is manifested in the reduction of indicator enzymes: aspartate aminotransferase, alanine aminotransferase.
REMAXOL® helps to reduce bilirubin and its fractions, improves the excretion of direct bilirubin in bile. Reduces the activity of excretory enzymes of hepatocytes-alkaline phosphatase and gamma-glutamyltranspeptidase, contributes to the oxidation of cholesterol into bile acids.
Pharmacokinetics
With intravenous drip infusion, the constituent natural components are quickly distributed in the body tissues, being utilized almost instantly. Metabolism products are excreted in the urine and do not accumulate in the body.
Indications
- Liver dysfunction due to acute or chronic liver damage:
- Toxic hepatitis.
- Alcoholic hepatitis.
- Medicinal hepatitis.
Composition
Active substances:succinic acid - 5,280 g; N-methylglucamine (meglumine) - 8.725 g; Riboxin (inosine) - 2.0 g; methionine - 0.75 g; Nicotinamide - 0.25 g;
Excipients:sodium chloride - 6.0 g; potassium chloride - 0.30 g; magnesium chloride (in terms of anhydrous) - 0.12 g; sodium hydroxide - 1,788 g; water for injection up to 1.0 l
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Dosage and Administration
Remaxol is administered only intravenously in a daily dose of 400 ml to 800 ml for 3-12 days, depending on the severity of the disease. The rate of introduction of 40 - 60 drops (2-3 ml) per minute.
Adverse reactions
With the rapid introduction of the solution, the appearance of undesirable reactions is possible: hyperemia of the skin of varying severity, feeling of heat, sore throat, dry mouth that do not require discontinuation of the drug.
Allergic reactions in the form of an allergic rash and pruritus are possible, which are eliminated by using antihistamines.
Rare nausea, nausea, headache, and dizziness.
Due to the activation of the drug aerobic processes in the body may decrease the concentration of glucose and increase the uric acid content in the blood.
Contraindications
- Individual intolerance to the components of the drug.
- Pregnancy.
- Lactation period.
- Childhood.
Carefully:
- Nephrolithiasis.
- Gout.
- Hyperuricemia.
Drug interactions
It is not recommended to mix in one bottle with other drugs for intravenous administration.
Special instructions
Non-wettability of the inner surface of the bottle is not a contraindication to the use of the drug.
- Brand name: Remaxol
- Active ingredient: Succinic acid, Meglumin, Riboxin, Methionine, Nicotinamide
- Dosage form: injection
- Manufacturer: Polysan
- Country of Origin: Russia
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