Buy Chlorprothixen pills 15 mg, 50 pcs
  • Buy Chlorprothixen pills 15 mg, 50 pcs

Truxal® [Chlorprothixen]

Zentiva KS
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Clinical Pharmacology

The antipsychotic effect of Chlorprothixene is associated with its blocking effect on dopamine receptors. The blocking of these receptors is also associated antiemetic and analgesic properties of the drug. Chlorprothixene is able to block 5-HT2 receptors, α1 - adrenoreceptors, and H1 - histamine receptors, which determine its adrenergic blocking hypotensive and antihistamine properties.

The oral bioavailability of chlorprotixen is about 12%. Chlorprothixene is rapidly absorbed from the intestines, Cmax in serum is reached after 2 hours. T1/2 is about 16 hours. Chlorprothixene penetrates the placental barrier and is excreted in small amounts with breast milk. Metabolites do not have neuroleptic activity, are excreted in feces and urine.


Chlorprothixene is a sedative neuroleptic with a wide range of indications, which include:

  • psychosis, including schizophrenia and manic states, occurring with psychomotor agitation, agitation and anxiety;
  • "hangover" "abstinence syndrome in alcoholism and drug addiction


1 tablet, film coated, contains:
active ingredient: Chlorprothixene hydrochloride 50 mg,
excipients: corn starch, lactose monohydrate, sucrose, calcium stearate, talc;
the composition of the shell: hypromellose 2910/5, macrogol 6000, macrogol 300, talc, M-1-1-6181 (yellow).

Chlorprothixen is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Chlorprothixen Zentiva KS Czech pills
Truxal Lundbeck AS Denmark pills

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Truxal® [Chlorprothixen]

Dosage and Administration

Psychoses, including schizophrenia and manic states.

Treatment begins with 50-100 mg / day, gradually increasing the dose to achieve the optimal effect, usually up to 300 mg / day. In some cases, the dose may be increased to 1200 mg / day. Maintenance dose is usually 100-200 mg / day. The daily dose of Chlorprothixene Zentiva is usually divided into 2-3 doses, given the pronounced sedative effect of Chlorprothixene Zentiva, it is recommended to prescribe a smaller part of the daily dose in the daytime, and most of it in the evening.

Hungover withdrawal syndrome with alcoholism and drug addiction.

The daily dose divided into 2-3 doses is 500 mg. The course of treatment usually lasts 7 days. After disappearance of withdrawal symptoms, the dose gradually decreases. Maintenance dose of 15-45 mg / day helps stabilize the condition, reduces the risk of developing the next binge.

In elderly patients with hyperactivity, irritability, arousal, confusion, 15-90 mg / day is prescribed. The daily dose is usually divided into 3 doses.

In children, for the correction of behavioral disorders, Chlorprothixene Zentiva is administered at the rate of 0.5–2 mg / kg body weight.

Depressive states, neuroses, psychosomatic disorders.

Chlorprothixene Zentiva can be used for depression, especially when combined with anxiety, tension, as an adjunct to antidepressant therapy or independently. Chlorprothixene Zentiva can be prescribed for neurosis and psychosomatic disorders, accompanied by anxiety and depressive disorders up to 90 mg / day. The daily dose, as a rule, is divided into 2-3 doses. Since taking Chlorprothixene Zentiva does not cause the development of addiction or drug dependence, it can be used for a long time.

Insomnia. At 15 - 30 mg in the evening for 1 hour before bedtime.

Pains The ability of Chlorprothixene Zentiva to potentiate the action of analgesics can be used in the treatment of patients with pain. In these cases, Chlorprothixene Zentiva is prescribed together with analgesics in doses of 15 to 300 mg.

Adverse reactions

Drowsiness, tachycardia, dry mouth, excessive sweating, difficulty of accommodation. These side effects, usually occurring at the beginning of therapy, often disappear as it continues.

Orthostatic hypotension may occur, especially when Chlorprothixene is used in high dosages.

Dizziness, dysmenorrhea, skin rashes, constipation are rare. Extrapyramidal symptoms are especially rare.

Described isolated cases of decrease in seizure threshold, the occurrence of transient benign leukopenia and hemolytic anemia.

With prolonged use, especially in high doses, there may be: cholestatic jaundice, galactorrhea, gynecomastia, decreased potency and / or libido, increased appetite, increased body weight.


  • hypersensitivity to the components of Chlorprothixene;
  • oppression of the central nervous system of any origin (including that caused by alcohol, barbiturates or opiates);
  • coma;
  • vascular collapse;
  • diseases of the blood;
  • pheochromocytoma.

Drug interactions

The inhibitory effect of Chlorprothixene on the central nervous system can be enhanced while taking it with ethanol and ethanol-containing drugs, anesthetics, opioid analgesics, sedatives, hypnotics, antipsychotics.
The anticholinergic effect of Chlorprothixene is enhanced with the simultaneous use of anticholinergic, antihistamine and anti-Parkinsonian drugs.
The drug enhances the action of antihypertensive drugs.
The simultaneous use of Chlorprothixene and adrenaline can lead to arterial hypotension and tachycardia.
The use of Chlorprothixene reduces the seizure threshold, which requires an additional dose adjustment of antiepileptic drugs in patients with epilepsy.
The ability of Chlorprothixene to block dopamine receptors reduces the effectiveness of levodopa.
Extrapyramidal disorders may occur with simultaneous use of phenothiazines, metoclopramide, haloperidol, reserpine.

Pregnancy and Lactation

If possible, Chlorprothixene should not be given to pregnant women during breastfeeding.

Special instructions

Chlorprothixene should be used with caution in patients suffering from epilepsy, parkinsonism, in severe cerebral atherosclerosis, with a tendency to collapse, in severe cardiovascular and respiratory failure, in severe impaired liver and kidney function, diabetes, prostatic hypertrophy.
The use of Chlorprothixene can lead to a false positive result when carrying out an immunobiological test of urine for pregnancy, a false increase in the level of bilirubin in the blood, a change in the QT interval on an electrocardiogram.
During drug treatment, it is recommended to refrain from the use of alcoholic beverages, to avoid increased insolation.

Influence on ability to drive motor transport and control mechanisms
The intake of Chlorprothixene has a negative effect on activities that require a high rate of mental and physical reactions (for example, driving, maintaining cars, working at height, etc.).


Symptoms Drowsiness, hypo-or hyperthermia, extrapyramidal symptoms, convulsions, shock, coma.

Treatment. Symptomatic and supportive. Gastric lavage should be performed as soon as possible, the use of a sorbent is recommended. Measures should be taken to support the activity of the respiratory and cardiovascular systems. Do not use adrenaline, because this can lead to a subsequent lowering of blood pressure. Spasms can be stopped by diazepam, and extrapyramidal disorders biperidenom.

  • Brand name: Chlorprothixen
  • Active ingredient: Chlorprothixen
  • Dosage form: Film Coated pills
  • Manufacturer: Zentiva KS
  • Country of Origin: Czech

Studies and clinical trials of Chlorprothixen (Click to expand)

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