Buy Heptor pills 400 mg 40 pcs
  • Buy Heptor pills 400 mg 40 pcs


Ademetionine is a cosubstrate involved in several metabolic processes. It is used to treat liver injury and is also shown to be potentially effective for various mental conditions such as depression, parkinson's and alzheimer's.

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Geptral is a medication that is used to treat liver disorders and depression. Several studies also suggests that the drug can be used to treat other mental disorders as well. The active ingredient of Geptral is S-Adenosylmethionine (Ademetionine).

Ademetionine is the methyl donor to numerous and diverse acceptor molecules including DNA, proteins, phospholipids and catechol- and indoleamines.

The therapeutic effect of Geptral in some depressive illnesses has led to new nontoxic treatment strategies. There have been encouraging pilot studies of the use of Ademetionine in patients with Parkinson’s disease, epilepsy and Alzheimer’s dementia. Furthermore, impaired C-I metabolism and Heptral synthesis has been proposed to be a common pathogenic mechanism in Alzheimer’s dementia, Down’s syndrome and HIV infection, thus lending further support for clinical trials with methyl donors in these conditions.

Convincing evidence from studies of inborn errors of methyl group metabolism have shown that methylation is important in maintaining the integrity of the myelin sheath. Correction of the methyl group deficiency with methyl group donors, including oral Ademetionine treatment, can halt or even reverse the demyelination process. Heptral appears to influence monoamine neurotransmitter metabolism and receptors, which may be the putative mechanism of action in the treatment of depression.

Clinical trials to date with Heptral have shown it to be a relatively safe compound, with no serious adverse reactions observed, and it is devoid of any hepatotoxic effects. This is probably related to the fact that it is a natural ubiquitous metabolite present in all organisms. The full clinical potential of Ademetionine in some neurological disorders remains to be explored.

Indications for use are:

  • Depression
  • Osteoarthritis
  • Alcohol related liver disease
  • Intrahepatic cholestasis
  • Fibromyalgia

Ademetionine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Heptor Veropharm Russia pills
Heptral AbbVie SRL Italy pills
Heptral AbbVie SRL Italy vials
Heptor Veropharm Russia solution

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Dosage and Administration

During the period of maintenance therapy, a daily dose of 800–1600 mg (2–4 pills) is recommended. The duration of maintenance therapy is on average 2-4 weeks. pills should be swallowed whole, without chewing. To improve the therapeutic effect of pills, it is recommended to take between meals.

Adverse reactions

Due to the fact that the active substance of the drug has an acidic pH, some patients may experience discomfort in the epigastric region when using pills. In any case, these feelings are short-lived, they are not pronounced and should not be a reason for stopping the course of treatment.



Drug interactions

No known interactions with other drugs were observed.

Pregnancy and Lactation

Not recommended in the I-II trimester of pregnancy and lactation.

Special instructions

Given the tonic effect of the drug, it is not recommended to take before bedtime. Oral use of the drug in patients with cirrhosis associated with hyperazotemia should be carried out under the supervision of a physician with controlled nitrogen levels. A pill of the drug Geptor must be removed from the packaging immediately before taking. The pills of the drug are coated with a special coating that dissolves only in the intestines, so that ademetionin is released in the duodenum.


Clinical cases of overdose were noted.

  • Brand name: Heptor
  • Active ingredient: Ademetionine
  • Dosage form: Enteric-coated pills.
  • Manufacturer: Veropharm

Studies and clinical trials of Ademetionine (Click to expand)

  1. A new medical approach to the treatment of osteoarthritis: Report of an open phase IV study with ademetionine (Gumbaral)
  2. PP-065 Therapeutical effect of Ademetionine (Transmetil) for chronic cholestasis diseases
  3. Ademetionine 1, 4- ButanedisulphonatevsTraditional Chinese Medicine for the Treatment of Acute Viral Hepatitis with Hepatocellular Jaundice
  4. Ademetionine 1,4 ButanedisulphonatevsTraditional Chinese Medicine for the Treatment of Hepatocellular Jaundice Complicating Chronic Viral Hepatitis
  5. Role of Ademetionine (S-Adenosylmethionine) in Cyclosporin-Induced Cholestasis
  6. Effects of a Low Dose of Oral Ademetionine (SAMe) on Behaviour and Quality of Life in Elderly Patients with Mild Mood Disorders
  7. Ademetionine improves QOL in affective disorders
  8. Ademetionine (S-adenosylmethionine) neuropharmacology: implications for drug therapies in psychiatric and neurological disorders
  9. Ademetionine improves QOL in elderly patients with affective disorders
  10. Heptral® (Ademetionine) in Intrahepatic Cholestasis due to Chronic Non-Alcoholic Liver Disease: Subgroup Analysis of Results of a Multicentre Observational Study in India
  11. Meta-analysis of 2 European multicenter controlled trials with ademetionine (SAMe) in major depression
  12. Heptral® (Ademetionine) in Patients with Intrahepatic Cholestasis due to Chronic Alcoholic Liver Disease: Results of a Multicentre Observational Study in Indian Patients
  13. Ademetionine
  14. The Clinical Potential of Ademetionine (S-Adenosylmethionine) in Neurological Disorders
  15. S-Adenosylmethionine (Ademetionine) in Psychiatric Disorders
  16. Ademetionine has clinical potential in depression
  17. Ademetionine/clomipramine
  18. Ademetionine
  19. Ademetionine is comparable to NSAIDs in activated gonarthrosis
  20. Ademetionine Decreases Prolactin Levels in Depressed Patients
  21. Ademetionine Appears More Effective than Placebo in Osteoarthritis
  22. Antidepressant as well as antirheumatic activity is demonstrated by ademetionine
  23. Rheumatic Patients Respond Well to Ademetionine

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