Clobetasol

Brand Elfa Pharmaceutical Plant

In stock 742 Items

Available since: 2019-09-19

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Clinical Pharmacology

Clovate® - GCS for external use.
Warns neutrophil marginal accumulation, reduces inflammatory exudation and cytokine production, inhibits macrophage migration, reduces the intensity of infiltration and granulation processes.
It has local anti-inflammatory, antipruritic, anti-allergic and anti-exudative effects.
Pharmacokinetics: Absorption
The average Cmax of clobetasol propionate is 0.63 ng / ml and is achieved in plasma 13 hours after the first application and 8 hours after repeated application of 30 g of clobetasol propionate to healthy skin in the form of 0.05% ointment. 10 hours after the application of the second dose (30 g) of clobetasol propionate in the form of a cream, its average plasma Cmax slightly exceeds that after applying the ointment. After 3 h after a single application of 25 g of 0.05% clobetasol propionate ointment in patients with psoriasis and eczema, the average Cmax of the drug in plasma is 2.3 ng / ml and 4.6 ng / ml, respectively.
When applied to large areas of skin, absorption is possible (damage to the integrity or inflammation of the skin increases absorption) and a systemic effect.
Metabolism and excretion
Metabolized mainly in the liver, a small part - in the kidneys. Excreted in the urine.

Indications

- psoriasis (with the exception of pustular and extensive plaque psoriasis);
- eczema (various forms);
- lichen planus;
- discoid lupus erythematosus;
- skin diseases that are resistant to treatment with less active corticosteroids for topical use.

Composition

1 g:
- clobetasol propionate 500 mcg
Excipients: propylene glycol - 50 mg, sorbitan sesquioleate - 5 mg, white petrolatum - up to 1 g.

Clobetasol is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Clovate®	Elfa Pharmaceutical Plant	Poland	ointment
Powercort®	Glenmark	India	cream
Dermovate®	GlaxoSmithKline Pharmaceuticals SA	Poland	ointment
Dermovate®	GlaxoSmithKline Pharmaceuticals SA	Poland	cream

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Dosage and Administration

Apply externally. Clovate® cream or ointment is applied with a thin layer to the affected skin 1-2 times / day. The duration of the continuous course of treatment is limited to 3-4 weeks.
In particularly resistant cases, especially in the presence of hyperkeratosis, the anti-inflammatory effect of Clovate® can be enhanced by overlaying the overlay over the area of use of the preparation with a plastic film dressing, which is usually accompanied by a positive effect. When changing the occlusive dressing, the skin must be cleaned. In the future, the achieved effect can be maintained without the use of an occlusive dressing.

Adverse reactions

Dermatological reactions: burning, itching, steroid acne, dry skin; with prolonged use - the weakening of the barrier function of the skin; with long-term use in high doses - atrophic changes in the skin, in particular, its thinning, the appearance of atrophic bands (stria), expansion of the surface blood vessels, especially when applying occlusive dressings and when applying the drug pas skin areas with folds; skin pigmentation and hypertrichosis may develop. In rare cases, the treatment of psoriasis corticosteroids for external use (or their cancellation) provokes the development of pustular psoriasis.
When applied to large surfaces, systemic side effects may develop: gastritis, ulceration of the gastrointestinal mucosa, increased intraocular pressure, symptoms of hypercorticism.
Prolonged administration of GCS for external use in large doses or applying them to large areas of skin may be accompanied by systemic absorption, followed by the development of symptoms of hypercorticism. The risk of this complication is increased in children, especially when using an occlusive dressing, and the diaper can play the role of such a dressing. Provided that Clovate® is prescribed to adult patients at a dosage of not more than 50 g per week, the suppression of the function of the pituitary and adrenal glands has a transient character with their rapid recovery immediately after the end of the course of treatment.
In rare cases, Clovet® may cause exacerbation of symptoms.

Contraindications

- rosacea;
- acne vulgaris;
- skin cancer;
- knotty scratch-head;
- perioral dermatitis;
- perianal and genital pruritus;
- skin manifestations of syphilis;
- diaper rash;
- bacterial, viral and fungal diseases of the skin (including herpes simplex, chicken pox, skin tuberculosis, actinomycosis);
- common plaque and pustular psoriasis;
- age up to 1 year;
- pregnancy;
- lactation period;
- Hypersensitivity to the components of the drug Clovate®.

Special instructions

Clovate® ointment is recommended to be used for skin lesions, accompanied by dryness, hyperkeratosis, and thickening.
Clovet® cream is recommended for the treatment of acute inflammatory skin diseases, incl. accompanied by the development of soak, as well as for the treatment of inflammation of the skin of the scalp.
The drug is recommended for short-term use.
It is necessary to avoid the appointment of GCS for external use for a long time, especially in the treatment of young children, since this may suppress the function of the adrenal glands. The use of the drug Clovate® in children requires the supervision of a doctor at least 1 time per week.
On the face more often than on other parts of the body, atrophic changes in the skin may appear as a result of prolonged use of external forms of GCS.
Do not apply the drug Clovate® in the eye area, because use of the drug in the periorbital region may cause the development of glaucoma.
Treatment of psoriasis GKS for external use may be accompanied by the development of disease recurrence, drug tolerance, generalized pustular form of the disease, local or systemic toxic reactions due to impaired barrier function of the skin, so careful monitoring of the patient is especially important.
When joining a secondary infection, appropriate antibiotic therapy should be carried out. For any signs of generalization of the infection, it is necessary to stop the external use of GCS and to conduct appropriate treatment with antibacterial drugs.The warm, humid conditions created by the application of an occlusive dressing contribute to the occurrence of a bacterial infection, so you should always cleanse the skin before applying a new dressing.
Clovate® cream is not recommended to be diluted.
Influence on ability to drive motor transport and control mechanisms
The use of the drug does not affect the patient's ability to perform work that requires increased attention and speed of psychomotor reactions.

Overdosage

The development of acute overdose is unlikely. However, in the case of chronic overdose or improper use, symptoms of hypercorticism may develop, which requires the gradual withdrawal of the drug under medical supervision.