Furazidin
Olainfarm
693 Items
2019-09-19
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Clinical Pharmacology
Furagin-antibacterial drug, a derivative of nitrofuran. Acts bacteriostatic. The mechanism of action of Furagin is associated with effects on enzymes involved in the transfer of hydrogen in cells of sensitive microorganisms. High bacteriostatic activity of Furagin is associated with the presence of an aromatic nitro group.
A drug active against gram-positive bacteria: Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus faecalis; Gram-negative bacteria: Enterobacteriaceae, Escherichia coli, Klebsiella pneumoniae.
To drug steady Pseudomonas aeruginosa.
The minimum bacteriostatic concentration of Furagin (1 μg / ml) is 10–20 times lower than other nitrofuran derivatives. The most pronounced effect of Furagin is in an acidic medium (pH 5.5), an alkaline medium prevents the action of the drug.
Indications
- treatment of acute and chronic infectious and inflammatory diseases of the urinary tract and prostate gland;
- prevention of recurrent urinary tract infections (including in children with congenital malformations of the urinary system, in adults with prolonged catheterization).
Composition
active substance: Furazidin 50 mg
Furazidin is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Furagin | Olainfarm | Latvia | pills |
| Urofuragin | Polfa | Poland | pills |
| Furagin-Aktifur | Obolensky OP | Russia | capsules |
| Furagin | Obolensky OP | Russia | pills |
| Furagin-SZ | North Star | Russia | pills |
| Furasol | Olainfarm | Latvia | tea bags |
| Furamag | Olainfarm | Latvia | capsules |
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Dosage and Administration
For treatment for adults prescribed on the first day of therapy 100 mg (2 tab.) 4 times / day, in the following days - 100 mg 3 times / day.
For children the drug is prescribed in a daily dose of 5-7 mg / kg of body weight, with long-term treatment - in a daily dose of 1-2 mg / kg.
The course of treatment is 7-8 days. If necessary, after 10-15 days, the treatment can be repeated.
For prophylaxis the drug is prescribed in 50 mg (1 tab.) 1 time / day (preferably in the evening).
pills should be taken with food containing proteins.
Adverse reactions
From the digestive system: diarrhea, dyspeptic symptoms, abdominal pain, constipation, vomiting.
From the side of the central nervous system and peripheral nervous system: dizziness, drowsiness, blurred vision; rarely polyneuropathy.
Allergic reactions: rash, itching.
Other: fever, chills, malaise; rarely, pulmonary reactions caused by hypersensitivity to nitrofuran derivatives.
Contraindications
- renal failure;
- polyneuropathy (including diabetic);
- deficiency of glucose-6-phosphate dehydrogenase;
- pregnancy: the period between the 38th and 42nd weeks;
- lactation;
- Hypersensitivity to nitrofuran derivatives.
The drug is not prescribed to newborns until the end of the first month of life.
Drug interactions
With simultaneous use of Furagin and nalidixic acid, a decrease in the bacteriostatic action of Furagin is noted.
With simultaneous use of Furagin and uricosuric drugs (probenecid, sulfinpyrazon), furazidine is excreted in the urine, which leads to a decrease in its therapeutic efficacy. This can lead to cumulation of furazidine in the body and increase the toxicity of Furagin.
With simultaneous use of Furagin and antacids containing magnesium trisilikat, Furagin absorption is reduced.
Special instructions
Precautions should be prescribed Furagin diabetics, because With the use of the drug may appear symptoms of polyneuropathy.
It is not recommended to prescribe Furagin for urosepsis, as well as for kidney parenchyma infections.
During the period of application of Furagin, false-positive results of the determination of glucose in the urine with the use of Benedict and Fehling solutions can be observed. The results of determination of glucose in the urine, performed by enzymatic methods, remain correct.
Control of laboratory parameters
During prolonged treatment with Furagin, the level of leukocytes in the blood should be periodically monitored, as well as indicators of liver and kidney function.
Influence on ability to drive motor transport and control mechanisms
Furagin does not affect the speed of psychomotor reactions, so it can be prescribed to patients whose activities require increased attention.
Overdosage
Symptoms: headache, dizziness, depression, psychosis, peripheral polyneuritis, allergic reactions (urticaria, angioedema, bronchospasm), nausea, vomiting, megaloblastic or hemolytic anemia (in people with glucose deficiency 6-phosphate dehydrogenase); very rarely - abnormal liver function.
Treatment: gastric lavage, IV the introduction of infusion solutions; in severe cases, hemodialysis is indicated.
- Brand name: Furacilin
- Active ingredient: Nitrofural
- Dosage form: pills for preparation of solution for topical administration.
- Manufacturer: Tyumen HFZ
- Country of Origin: Russia
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