Glucosamine, Chondroitin Sulfate
Bayer Pharma AG
1655 Items
2019-09-19
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Clinical Pharmacology
Glucosamine/Chondroitin sulfate combo is a stimulator of cartilage tissue regeneration.
Glucosamine and chondroitin sodium sulfate are involved in the biosynthesis of connective tissue, helping to prevent the processes of cartilage destruction and stimulating tissue regeneration. Introduction of exogenous glucosamine enhances the production of cartilage matrix and provides non-specific protection against chemical damage to cartilage. Another possible function of glucosamine is to protect damaged cartilage from metabolic destruction caused by nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticosteroids (GCS), as well as its own moderate anti-inflammatory effect. Chondroitin sodium sulfate, regardless of whether it is absorbed in an intact form or as separate components, serves as an additional substrate for the formation of a healthy cartilage matrix. Stimulates the formation of hyaluronon, the synthesis of proteoglycans and type II collagen, and also protects hyaluronon from enzymatic degradation (by suppressing the activity of hyaluronidase) and from the damaging effects of free radicals; maintains the viscosity of the synovial fluid, stimulates the mechanisms of cartilage repair and inhibits the activity of those enzymes (elastase, hyaluronidase) that break down the cartilage. In the treatment of osteoarthritis, it relieves the symptoms of the disease and reduces the need for NSAIDs.
Glucosamine, Chondroitin Sulfate is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Teraflex | Bayer Pharma AG | Germany | capsules |
| ARTHRA | Unipharm | USA | pills |
| Condronova | Panacea Biotek | India | capsules |
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For adults and children over 15 years of age, the first 3 weeks are prescribed 1 capsule 3 times / day; the next days - 1 caps. 2 times / day, regardless of food intake, with a little water. The recommended duration of treatment is 3 to 6 months. If necessary, it is possible to carry out repeated courses of treatment, the duration of which is set individually.
- Brand name: Teraflex
- Active ingredient: Glucosamine, Chondroitin Sulfate
- Manufacturer: Bayer Pharma AG
- Country of Origin: Germany
Studies and clinical trials of Glucosamine, Chondroitin Sulfate (Click to expand)
- Glucosamine and chondroitin sulfate for the treatment of osteoarthritis: Comment on the article by Akama and Saito
- The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trial
- The bioavailability and pharmacokinetics of glucosamine hydrochloride and low molecular weight chondroitin sulfate after single and multiple doses to beagle dogs
- The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous single dose administration in the horse
- Incorporation of 35S-sulfate and 3H-glucosamine into heparan and chondroitin sulfates during the cell cycle of B16-F10 cells
- High levels of glucosamine–chondroitin sulfate can alter the cyclic preload and acute overload responses of chondral explants
- Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study
- Classification of chondroitin sulfate A, chondroitin sulfate C, glucosamine hydrochloride and glucosamine 6 sulfate using chemometric techniques
- Fursultiamine, a vitamin B1 derivative, enhances chondroprotective effects of glucosamine hydrochloride and chondroitin sulfate in rabbit experimental osteoarthritis
- Does the combination of chondroitin sulfate and glucosamine delay the cartilage destruction in ochronopathy?
- Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis
- Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model
- Effects of chondroitin sulfate and glucosamine in adult patients with Kaschin–Beck disease
- Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the “Magenta osteoarthritis study”
- Effects of oral glucosamine and chondroitin sulfate alone and in combination on the metabolism of SHR and SD rats
- Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs
- Isolation of a hyaluronate pool from the chondroitin sulfate peptide pool of calf rib cartilage. Effect of puromycin and SeO42− on pool labeling with 3H-glucosamine
- Comparison of Synovial Fluid in Middle Carpal Joints Undergoing Needle Aspiration, Infusion with Saline, and Infusion with a Combination of N-Acetyl-d-Glucosamine, Hyaluronic Acid, and Sodium Chondroitin Sulfate
- Plasma Concentration of Glucosamine and Chondroitin Sulfate in Horses after an Oral Dose
- Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants
- Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone
- The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination
- Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study
- Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis
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