Hexoral®

Brand Zoldan Holding + BonbonSpeciality GmbH

In stock 1353 Items

Available since: 2019-09-19

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Clinical Pharmacology

Hexoral - antiseptic.

The antimicrobial effect of Hexoral® is associated with the suppression of oxidative metabolic reactions of bacteria (thiamine antagonist). The drug has a broad spectrum of antibacterial and antifungal effects, in particular against gram-positive bacteria and fungi of the genus Candida, but Hexoral® may also have an effect in the treatment of infections caused by, for example, Pseudomonas aeruginosa or Proteus. At a concentration of 100 mg / ml, the drug inhibits most strains of bacteria. The development of sustainability was not observed. Hexetidine has a weak anesthetic effect on the mucous membrane.

Indications

Inflammatory and infectious diseases of the oral cavity and pharynx.
With the complex treatment of severe febrile or purulent diseases of the oral cavity and pharynx, requiring the appointment of antibiotics and sulfonamides, tonsillitis.
Sore throats (including sore throats with lesions of the lateral ridges, Plaut-Vincent sore throats).
Pharyngitis.
Gingivitis and bleeding gums.
Periodontal diseases (periodontal diseases and their symptoms).
Stomatitis (inflammation of the mucous membranes of the oral cavity), glossitis (inflammation of the tongue), aphthous ulcers (painful inflammation with superficial tissue defects) for the prevention of superinfection.
Infection of the alveoli (tooth holes) after tooth extraction.
Fungal infections of the mouth and pharynx, especially candidal stomatitis (thrush).
Before and after surgery in the mouth and throat.
Additional oral hygiene for general diseases.
Elimination of bad breath, especially in case of decaying tumors of the mouth and throat.
Auxiliary in the treatment of colds.

Composition

1 tablet contains:

Active substances: chlorhexidine dihydrochloride - 5 mg, benzocaine - 1.5 mg.

Excipients: isomalt, peppermint oil, menthol, thymol, aspartame, purified water.

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Dosage and Administration

The tablet should be slowly absorbed in the mouth until completely dissolved.

The drug should be started immediately after the first symptoms of the disease appear and continue to be taken for several days after the symptoms disappear.

Adults and children over 12 years old: as a rule, 1 tab. every 1-2 hours as needed, but not more than 8 tab./day.

Children aged 4-12 years: appoint up to 4 tab./day.

Use in children is possible only on prescription.

Do not use the drug in children under 4 years of age.

Adverse reactions

Local reactions: with prolonged use, a short-term taste disturbance and numbness of the tongue is possible; reversible discoloration of the teeth and tongue is also possible.

Allergic reactions: in the presence of hypersensitivity to benzocaine, in rare cases, hypersensitivity reactions may develop, up to anaphylactic shock.

Other: Benzocaine can cause the development of methemoglobinemia in children.

Contraindications

Children's age up to 3 years; hypersensitivity to the drug.

Drug interactions

Benzocaine reduces the antibacterial activity of sulfonamides and aminosalicylates due to the formation of a metabolite of 4-aminobenzoic acid.

Sucrose, polysorbate 80, insoluble magnesium, zinc and calcium salts reduce the effect of chlorhexidine.

Pregnancy and Lactation

Pregnant and lactating women should consult a doctor before using the drug.

Special instructions

Information for diabetics

If necessary, the use of the drug in patients with diabetes should consider that the carbohydrate content in 1 tablet corresponds to 0.1 XE.

Disposal rules

The patient should be informed that if the drug has become unusable or the expiration date has expired, then it should not be thrown into the wastewater or on the street. It is necessary to put the drug in the bag and put it in the trash. These measures will help protect the environment.

Overdosage

With the correct use of an overdose of the drug is impossible, because Chlorhexidine is practically not absorbed into the blood, and the amount of benzocaine absorbed is extremely small.

Chlorhexidine

Chlorhexidine hydrochloride is poorly soluble in water, all cases of overdose are described only when taking chlorhexidine gluconate, which is highly soluble in water.

Symptoms: damage to the mucous membrane during direct contact with chlorhexidine gluconate, as well as a systematic reversible increase in the concentration of hepatic enzyme.

Treatment: no specific treatment.

Benzocaine

Overdose is possible only if used improperly.

Symptoms: possibly toxic effects on the central nervous system, which manifests itself initially tremor, vomiting, convulsions, and later - the oppression of the central nervous system. Due to respiratory depression, coma is possible. High toxic concentrations cause bradycardia, AV conduction blockade and cardiac arrest. Benzocaine can cause methemoglobinemia (especially in children), accompanied by suffocation and cyanosis.

Treatment: cause vomiting and flush the stomach. Perhaps the appointment of Activated charcoal. During hypoxia and anoxia, artificial respiration with oxygen support is recommended, while cardiac arrest is cardiac massage. For convulsions, diazepam or fast-acting barbiturates are prescribed (contraindicated in anoxic convulsions); in severe cases, after intubation and artificial respiration, suxametonium chloride is used. Blood circulation is supported by the introduction of blood plasma or electrolyte solutions. With methemoglobinemia, up to 50 ml of a 1% solution of methylene blue IV may be used.