Lopinavir/Ritonavir

Kaletra is a combination drug that contains lopinavir and ritonavir. Lopinavir is an inhibitor of HIV-1 and HIV-2 protease of the human immunodeficiency virus (HIV) and provides antiviral activity of the drug Kaletra. Inhibition of HIV proteases inhibits the synthesis of viral proteins, which leads to the formation of an immature and incapable of infection of the virus. Ritonavir is an HIV-1 and HIV-2 aspartyl protease inhibitor for oral administration, an active peptidomimetic. Inhibition of HIV proteases prevents the cleavage of the bond by a group-specific antigen polymerase (gag-pol) polyprotein, which also leads to the formation of an immature and non-infectious virus. Ritonavir has a selective affinity for HIV protease and shows little activity against human aspartyl protease.