Buy Pyrantel pills 250 mg, 3 pcs
  • Buy Pyrantel pills 250 mg, 3 pcs

Pyrantel

Polpharma
1509 Items
2019-09-19
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$23.44
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Clinical Pharmacology

Pyrantel - antihelminthic.

Blocks neuromuscular transmission in sensitive worms.

Pharmacodynamics

It acts on helminths in the early phase of development and on mature forms, does not affect the larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics

Practically not absorbed in the digestive tract. After ingestion in a single dose of 10 mg / kg body weight Cmaxis 0.005–0.13 mcg / ml and is achieved within 1–3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in feces (50% of the dose taken - unchanged) and with urine (about 7% - unchanged and as a metabolite).

Indications

Enterobiasis, ascariasis, hookworm, necatoriasis.

Composition

1 tablet contains:

Active ingredient: Pyrantel 250 mg;

Excipients: starch, gelatin, acacia gum, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium carboxymethyl starch, talc, magnesium stearate, colloidal silicon dioxide (aerosil).

Pyrantel is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Pyrantel Polpharma Poland pills
Pyrantel Oxford Laboratories Pvt. Ltd India suspension
Pyrantel Medana Pharma Poland suspension
Helmintox Innotech International France Gel

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Pyrantel

Dosage and Administration

Inside Dose and frequency of administration set individually, depending on the evidence, age and body weight of the patient.

In case of ascariasis and enterobiasis, a single dose of 10 mg / kg is prescribed: for adults and children over 12 years old - 750 mg (for body mass more than 75 kg - 1 g); children from 6 months to 2 years old - 125 mg, 2-6 years old - 250 mg, 6-12 years old - 500 mg. To avoid self-invasion, it was recommended to repeat the course 3 weeks after the first dose.

With hookworm - 10 mg / kg in 1 reception for 3 days.

For necatoriasis (severe forms) - 20 mg / kg / day for 2 days.

With isolated ascariasis - 5 mg / kg once.

Chewable pills before swallowing.

Adverse reactions

From the nervous system and sensory organs: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing loss, hallucinations, confusion, paresthesia.

On the part of the digestive tract: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of hepatic transaminases.

Other: skin rash, fever.

Contraindications

Hypersensitivity.

Pregnancy and Lactation

Pyrantel is contraindicated for use in pregnancy.

If necessary, use during lactation should decide on the termination of breastfeeding.

Special instructions

When enterobiasis should be the simultaneous treatment of co-residents. After completion of treatment it is necessary to conduct a control study of feces on the eggs of the worm.

  • Active ingredient: Pyrantel

Studies and clinical trials of Pyrantel (Click to expand)
  1. Bioequivalence of pyrantel pamoate dosage forms in healthy human subjects
  2. Spectrophotometric determination of pyrantel in pyrantel pamoate bulk samples and pharmaceutical formulations
  3. The comparative metabolism of pyrantel in five species
  4. Ion-selective membrane electrodes for the determination of pyrantel with low protein interference
  5. The treatment of Fasciolopsis buski infection in children: a comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene
  6. Synthesis and nematocidal activities of new analogs of pyrantel
  7. Resistance of Oesophagostomum spp. in pigs to pyrantel citrate
  8. Determination of the efficacy of pyrantel pamoate at the therapeutic dose rate against the tapeworm Anoplocephala perfoliata in equids using s modification of the critical test method
  9. A dose-response investigation on the level of resistance to pyrantel citrate in nodular worms of pigs
  10. Effect of early season ivermectin and pyrantel treatments on strongylid infections in young Shetland ponies in The Netherlands
  11. Efficacy of an ivermectin/pyrantel pamoate chewable formulation against the canine hookworms, Uncinaria stenocephala and Ancylostoma caninum
  12. Efficacy of pyrantel tartrate against experimental infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis in goats
  13. Controlled efficacy study of the bioequivalence of strongid® C and generic pyrantel tartrate in horses
  14. Comparison of daily and monthly pyrantel treatment in yearling Thoroughbreds and the protective effect of strategic medication of mares on their foals
  15. Adsorption of pyrantel pamoate on mercury from aqueous solutions: Studies by stripping voltammetry
  16. Synergic effect of metronidazole and pyrantel pamoate on Giardia lamblia
  17. Clinical field efficacy and safety of pyrantel pamoate paste (19.13% w/w pyrantel base) against Anoplocephala spp. in naturally infected horses
  18. Comparative effects of milbemycin oxime-based and febantel–pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups
  19. Dose-confirmation studies of the cestocidal activity of pyrantel pamoate paste in horses
  20. Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin
  21. Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate
  22. High-level pyrantel resistance in the hookworm Ancylostoma caninum
  23. Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms
  24. Field evaluation of the efficacy and the safety of a combination of oxantel/pyrantel/praziquantel in the treatment of naturally acquired gastrointestinal nematode and/or cestode infestations in dogs in Europe

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