Mebendazole

Brand Cadilla

In stock 1811 Items

Available since: 2019-09-19

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Clinical Pharmacology

Anti-worming agent of a broad spectrum; most effective in enterobiasis. It causes an irreversible violation of glucose utilization in the body of the helminth and inhibits the synthesis of ATP.

Indications

Enterobiosis, ascariasis, ankilostomidoz, strongyloidosis, trichocephalosis, trichinosis, teniasis, echinococcosis, alveococcosis, capillariosis, gnatostomosis, mixed helminthiasis.

Composition

One tablet Wormin®a:

0.1 g of mebendazole.

Auxiliary components:

Calcium phosphate;
Magnesium stearate;
Sodium lauryl sulfate;
Food Color Sunset orange;
Starch;
Gelatin;
Talc;
Food Color Sunset yellow;
Vanillin.

Mebendazole is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Wormin®	Cadilla	India	pills
Vermox	Gedeon Richter	Hungary	pills

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Dosage and Administration

Adults and children over 10 years old with enterobiasis - at a dose of 100 mg once.

Children aged 2 to 10 years - at a dose of 25-50 mg once. In the case of a high likelihood of re-invasion, repeat administration after 2-4 weeks at the same dose.

It is recommended that simultaneous treatment of all family members.

In case of ascariasis, trichocephalosis, ankilostomidosis, teniosis, strongyloidosis and mixed helminthiases - 100 mg in the morning and evening for 3 days. With trichinosis - 200-400 mg 3 times / day for 3 days, and from the 4th to the 10th day - 400-500 mg 3 times / day. When echinococcosis - 500 mg 2 times / day for the first 3 days, then at the same dose 3 times / day for the next 3 days. In the future, use a dose of 25-30 mg / kg / day in 3-4 doses.

Adverse reactions

On the part of the digestive system: rarely - nausea, abdominal pain; when used in high doses for a long time, vomiting, diarrhea, transient increase in the activity of hepatic transaminases in serum are possible.

From the side of the central nervous system: rarely - dizziness; when used in high doses for a long time, headache.

On the part of the blood system: when used in high doses for a long time, leukopenia, anemia, and eosinophilia are possible.

From the urinary system: when used in high doses for a long time - hematuria, cylindruria.

Other: when used in high doses for a long time - allergic reactions, hair loss.

Contraindications

Severe liver dysfunction, pregnancy, lactation (breastfeeding), children under 2 years old, hypersensitivity to mebendazole.

Drug interactions

Mebendazole reduces the need for insulin in diabetic patients.

Co-administration of mebendazole with lipophilic substances should be avoided. With the simultaneous use of cimetidine can increase, and carbamazepine and other inducers of metabolism - reduce the concentration of mebendazole in the blood.

Pregnancy and Lactation

Contraindicated for use in pregnancy and lactation (breastfeeding).

Special instructions

With prolonged use, it is necessary to control the picture of peripheral blood, liver and kidney function.

During the day after taking mebendazole to prevent the use of alcohol.

Do not use laxative after taking mebendazole.

Periodic examination of smears of the anal area and feces is necessary after the end of treatment (therapy is considered effective in the absence of worms or their eggs for 7 consecutive days).