Buy Yodopirone solution 1% bottle 450 ml
  • Buy Yodopirone solution 1% bottle 450 ml

Povidone-iodine, potassium iodide

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Clinical Pharmacology

Elemental iodine has pronounced antimicrobial properties. For preparations of elemental iodine, a pronounced local irritating effect on tissue is typical, and in high concentrations - a cauterizing effect. Local action is due to the ability of elemental iodine to precipitate tissue proteins. Drugs that chip off elemental iodine have a much less pronounced irritant effect, and iodides have local irritating properties only in very high concentrations.

The nature of the resorptive action of drugs of elemental iodine and iodides is the same. The most pronounced effect of the resorptive effect of iodine preparations on the function of the thyroid gland. When iodine deficiency iodides contribute to the restoration of impaired synthesis of thyroid hormones. With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, the thyroid gland's sensitivity to the TSH of the pituitary gland decreases, and its secretion by the pituitary gland is blocked. The effect of iodine preparations on the metabolism is manifested by an increase in dissimilation processes. In atherosclerosis, they cause some decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, they increase the fibrinolytic and lipoproteinase activity of the blood serum and slow down the rate of blood coagulation.

Accumulating in syphilitic gums, iodine contributes to their softening and resorption. However, the accumulation of iodine in the tubercular foci leads to an increase in the inflammatory process in them. Excretion of iodine by the excretory glands is accompanied by irritation of the glandular tissue and increased secretion. This is due to the expectorant effect and stimulation of lactation (in small doses). However, in large doses, iodine preparations can cause lactation inhibition.


For external use: infectious-inflammatory skin lesions, injuries, wounds, myalgia.

For local use: chronic tonsillitis, atrophic rhinitis, purulent otitis, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

For oral administration: prevention and treatment of atherosclerosis, tertiary syphilis.


1000 ml of solution contains: iodine - 14.1 g

Excipients: potassium iodide 13.8 g, low molecular weight povidone 122.1 g, purified water to 1000 ml.

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Povidone-iodine, potassium iodide

Dosage and Administration

Intravaginally. Pre-freeing the suppository from the contour cell packaging, it is introduced, lying on its back, deep into the vagina. In acute vaginitis - 1 suppository 2 times a day for 7 days, with subacute and chronic vaginitis - 1 suppository 1 time a day before going to bed for 14 days (regardless of the phase of the menstrual cycle).

Adverse reactions

Hypersensitivity reactions to the drug at the site of use: hyperemia, pruritus. Allergic reactions are possible, including contact dermatitis with the formation of psoriasis-like red small bullous elements. In the event of such phenomena, the use of the drug should be discontinued.


Hypersensitivity to iodine and other components of the drug, thyrotoxicosis (hyperthyroidism), Dürring herpetiform dermatitis, thyroid adenoma, simultaneous use of radioactive iodine, children under 8 years of age.
Chronic renal failure, pregnancy, breastfeeding period, old age.

Drug interactions

Povidone-iodine is incompatible with oxidizing agents, alkali salts and substances with an acidic reaction. It is not recommended to use povidone iodine simultaneously with hydrogen peroxide and agents containing mercury, silver and enzymes.

Pregnancy and Lactation

Iodoxide is contraindicated during pregnancy. The drug Iodoxide should not be used to treat the skin of premature and newborn babies.

Special instructions

In the presence of blood, the bactericidal effect of povidone-iodine may decrease.

In the case of non-manifest hyperthyroidism and other diseases of the thyroid gland (especially in elderly patients), the drug is used only under strict indications and under constant medical supervision.

Due to the oxidative properties of povidone-iodine, traces of it can lead to false-positive results of some types of studies for detecting occult blood in the feces, as well as blood or glucose in the urine.

During the use of povidone-iodine, the absorption of iodine by the thyroid gland may decrease, which may affect the results of some diagnostic tests (for example, thyroid scintigraphy, determination of protein-bound iodine, measurements using radioactive iodine) for the treatment of diseases of the thyroid gland. To obtain undistorted results of thyroid scintigraphy after prolonged therapy with povidone-iodine, it is recommended to withstand a sufficiently long period of time without this drug. If symptoms of hyperthyroidism occur during the course of treatment, it is necessary to check the function of the thyroid gland.

Caution should be exercised with regular use of the drug in patients with previously diagnosed renal insufficiency.

Regular use of Iodoxide® should be avoided in patients receiving lithium preparations.

It is recommended to be careful when introducing vaginal suppositories to virgins.

Color on the skin and tissues is easily washed off with water.

Suppositories have a spermicidal effect, and therefore their use is not recommended for people planning a pregnancy.

During the use of suppositories, you can recommend the use of sanitary pads.

After contact with the drug should avoid its contact with eyes.

Influence on ability to drive vehicles and work with mechanisms

Does not affect the ability to drive a car and other mechanisms.


Data on drug overdose Iodoxide not provided.

  • Brand name: Yodopirone
  • Active ingredient: Povidone-iodine, potassium iodide
  • Dosage form: Solution for external use 1%.
  • Manufacturer: Yuzhfarm
  • Country of Origin: Russia

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