Aevit

Brand Altaivitamin

In stock 620 Items

Available since: 2019-09-19

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Clinical Pharmacology

Action Aevita due to its constituent vitamins A and E.
Retinol Palmitate provides normalization mainly processes of protein and carbohydrate and, to a lesser extent, fat metabolism.
a-tocopherol acetate possesses powerful antioxidant properties, mainly normalizes fat metabolism.
Aevit restores capillary blood circulation, normalizes capillary and tissue permeability, tissue respiration; increases tissue resistance to hypoxia.

Indications

Hypo-and avitaminosis A and E, as well as the state of increased body need for vitamins A and E and / or a decrease in their intake: gastrectomy, diarrhea, steatorrhea, celiac disease, Crohn's disease, malabsorption syndrome, chronic cholestasis, liver cirrhosis, biliary atresia pathways, obstructive jaundice, cystic fibrosis of the pancreas, tropical sprue, infectious diseases (including chronic and "colds"), hemeralopia, xerophthalmia, keratomalacia, inadequate and unbalanced nutrition (including parenteral nutrition), fast thinning, nicotine addiction, drug addiction, alcoholism, a state of prolonged stress, taking Kolestiramine, Colestipol, mineral oils, neomycin, iron-containing products, when prescribing a diet with an increased content of polyunsaturated fatty acids, hyperthyroidism, pregnancy (including multiple fetuses), lactation period .

Peripheral neuropathy, necrotizing myopathy, abetalipoproteinemia.

Effectiveness is not proven - atherosclerotic changes of blood vessels, violations of tissue trophism, obliterating endarteritis.

Composition

1 capsule contains retinol palmitate (vitamin A) - 0.055 g (100,000 IU), a-tocopherol acetate (vitamin E) - 0.1 g;
Excipients - deodorized corn oil or hydrated soybean oil.

Aevit is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Aevit	Altaivitamin	Russia	capsules
			capsules

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Dosage and Administration

For oral use. 1 capsule for 30-40 days.

Adverse reactions

In the case of use in the recommended dosage is usually not marked.
Allergic reactions to the drug components are possible. In some cases, there may be dyspeptic symptoms in the form of discomfort in the epigastric region, nausea, diarrhea. With long-term administration in large doses, exacerbation of gallstone disease and chronic pancreatitis may occur.

Contraindications

Hypersensitivity to vitamins A and E. Children's age up to 14 years.

Drug interactions

Retinol weakens the effect of calcium supplements, increases the risk of hypercalcemia.

Kolestiramin, Kolestipol, mineral oils, neomycin reduce the absorption of vitamins A and E (you may need to increase their dose).

Oral contraceptives increase plasma retinol concentration.

Isotretinoin increases the risk of retinol intoxication.

The simultaneous use of tetracycline and retinol in high doses (50 thousand units and above) increases the risk of developing intracranial hypertension.

Tocopherol (vitamin E) enhances the effect of GCS, NSAIDs, antioxidants, increases efficiency and reduces the toxicity of vitamins A, D, cardiac glycosides. The administration of high-dose vitamin E may cause a deficiency in vitamin A in the body.

Tocopherol (vitamin E) increases the effectiveness of antiepileptic drugs in patients with epilepsy (who have elevated blood lipid peroxidation products).

The simultaneous use of vitamin E in a dose of more than 400 IU per day with anticoagulants (coumarin and indandion derivatives) increases the risk of hypoprothrombinemia and bleeding.

The use of high-dose iron supplements enhances the oxidative processes in the body, which increases the need for vitamin E.

Pregnancy and Lactation

Be wary appointed during pregnancy (especially the I term), during lactation.

Special instructions

In order to avoid the development of hypervitaminosis A and E, do not exceed the recommended doses.

When using the drug, it is necessary to take into account the high content of vitamin A in it (100 thousand IU), and also that it is a curative and not a prophylactic drug.

A diet with a high content of Se and sulfur-containing amino acids reduces the need for vitamin E.

Overdosage

Symptoms of acute overdose of retinol (vitamin A) (develop 6 hours after administration): hypervitaminosis A: in adults - drowsiness, lethargy, diplopia, dizziness, severe headache, nausea, severe vomiting, diarrhea, irritability, osteoporosis, bleeding from the gums, dryness and ulceration of the oral mucosa, peeling of the lips, skin (especially the palms), agitation, confusion.

Symptoms of chronic intoxication with retinol (vitamin A): anorexia, bone pain, cracks and dry skin, lips, dry oral mucosa, gastralgia, vomiting, hyperthermia, asthenia, headache, photosensitization, pollakiuria, nocturia, polyuria, irritability, loss hair, yellow-orange spots on soles, palms, in the area of the nasolabial triangle, hepatotoxic effects, increased intraocular pressure, oligomenorrhea, portal hypertension, hemolytic anemia, changes in radiographs of the bones, trial horns; phototoxic effects: in humans - malformations of the urinary system, growth retardation, early closure of the epiphyseal growth zones; in animals, there are malformations of the central nervous system, spine, chest, heart, eyes, upper palate, urinary system.

Symptoms of tocopherol overdose (vitamin E): when taken for a long period in doses of 400-800 U / day - blurred vision, dizziness, headache, nausea, diarrhea, gastralgia, asthenia; when taking more than 800 U / day for a long period - an increased risk of bleeding in patients with hypovitaminosis K, metabolic thyroid hormone metabolism, sexual dysfunction, thrombophlebitis, thromboembolism, necrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, hemorrhage, hemorrhage, sepsis, hepatomegaly, hyperbilirubinemia, renal failure, hemorrhage, hemorrhage, nephrotic colitis, sepsis, hepatomegaly, hyperbilirubinemia, renal failure eye shell, hemorrhagic stroke, ascites.

Treatment: drug withdrawal; symptomatic therapy.