Ascorbic Acid, Dextrose
Pharmstandard Ufavita
1442 Items
2019-09-19
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Clinical Pharmacology
Ascorbic acid has a metabolic effect, is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of steroid hormones; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1A b2, A, E, folic acid, pantothenic acid.
Indications
- hypo-and avitaminosis C;
- increased need for ascorbic acid (the period of intensive growth, pregnancy, lactation, increased physical activity, the period of convalescence).
Composition
1 tablet contains ascorbic acid 100 mg; dextrose 877 mg.
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Dosage and Administration
For oral use. Doses are given in terms of ascorbic acid.
Prophylactic adults - 50-100 mg / day, children - 25 mg / day.
Adults with a therapeutic goal - 50-100 3-5 times / day, children - 50-100 mg 2-3
During pregnancy and lactation - 300 mg / day. for 15 days, then - 100 mg per day.
Adverse reactions
Allergic reactions, irritation of the gastrointestinal mucosa (nausea, vomiting, diarrhea, gastrointestinal spasm); inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria); when used in high doses, hyperoxaluria and nephrocalcinosis (oxalate).
Changes in laboratory parameters: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Contraindications
Witch caution: diabetes, glucose-6-phosphate dehydrogenase deficiency; for use in high doses - hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, nephurolythiasis.
Drug interactions
Ascorbic acid increases the concentration in the blood of benzylpenicillin and tetracyclines; at a dose of 1 g / day. increases the bioavailability of ethinyl estradiol (including those included in oral contraceptives). It improves the absorption of iron preparations in the intestine (converts ferric iron to ferrous iron); may increase the excretion of iron while using with deferoxamine. Reduces the effectiveness of heparin and indirect anticoagulants.
Pregnancy and Lactation
When prescribing Ascorbic Acid, the instructions for use should be carefully studied.
Special instructions
In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the kidney function and blood pressure. With long-term use of large doses, the function of the insular apparatus of the pancreas may be inhibited, therefore during treatment it must be regularly monitored. In patients with a high content of iron in the body, ascorbic acid should be used in minimal doses. The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the process. Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, activity of liver transaminases and LDH).
Overdosage
Symptoms: when using more than 1 g - headache, increased central nervous system excitability, insomnia, nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract, pancreatic insular apparatus function (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (oxalate calcium) , damage to the glomerular apparatus of the kidneys, moderate pollakiuria (when taking a dose of more than 600 mg / day.). Reduced capillary permeability (possibly worsening tissue trophism, increased blood pressure, hypercoagulation, the development of microangiopathies.
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