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Aspirin - nonsteroidal anti-inflammatory agent (NSAID), non-narcotic analgesic, antiplatelet agent. It has antipyretic, analgesic and anti-inflammatory effects, as well as reduces platelet aggregation.
The main mechanism of action of acetylsalicylic acid is the irreversible inactivation of the enzyme cyclooxygenase, as a result of which the synthesis of prostaglandins, prostacyclins and thromboxane is disrupted.
Due to a decrease in prostaglandin production, the pyrogenic effect of prostaglandins on thermoregulation centers is reduced. In addition, the sensitizing effect of prostaglandins on sensitive nerve endings decreases (which leads to a decrease in their sensitivity to pain mediators).
Irreversible disruption of platelet synthesis of thromboxane A2 causes antiplatelet effect of acetylsalicylic acid.
At the same time, it should be noted that acetylsalicylic acid also blocks the cyclooxygenase of endothelial cells, in which prostacyclin is synthesized, which has antiaggregant activity. However, endothelial cell cyclooxygenase is less sensitive to acetylsalicylic acid and, unlike platelet enzyme, is blocked reversibly.
Adding vitamin C to the drug increases the body's resistance, reduces vascular permeability.
Symptomatic treatment of moderate or mild pain syndrome of different origin (headache, toothache, migraine, neuralgia, muscle pain, pain during menstruation); febrile syndrome in colds and other infectious and inflammatory diseases.
1 tablet contains:
- acetylsalicylic acid 400 mg,
- ascorbic acid 240 mg.
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Dosage and Administration
For oral use. Dissolve the effervescent tablet in a glass of water and drink after a meal.
With pain syndrome of weak and medium intensity and feverish conditions, a single dose is 1 -2 effervescent pills, the maximum single dose is 2 effervescent pills, the maximum daily dose should not exceed 6 pills. The intervals between doses of the drug should be at least 4 hours.
The duration of treatment (without consulting a doctor) should not exceed 3-5 days.
In order to reduce the risk of adverse reactions from the gastrointestinal tract, the minimum effective dose of the drug should be applied by the shortest course of treatment.
Violations of the gastrointestinal tract: often - loss of appetite; rarely diarrhea; frequency unknown - dyspepsia, abdominal pain, nausea, vomiting, overt (black stool, bloody vomiting) or hidden signs of gastrointestinal bleeding that can lead to iron deficiency anemia, erosive-ulcerative lesions (including perforations) of the gastrointestinal tract.
Nervous system disorders: infrequently - headache; frequency is unknown - dizziness, tinnitus (usually are signs of overdose).
Violations of the blood and lymphatic system: the frequency is unknown - hemorrhagic syndrome, thrombocytopenia. Bleeding can lead to acute or chronic anemia, iron deficiency anemia with appropriate laboratory and clinical manifestations (asthenia, pallor, hypoperfusion). Patients with glucose-6-phosphate dehydrogenase deficiency may experience hemolysis and hemolytic anemia.
Disturbances of the kidneys and urinary tract: the frequency is unknown - when used in high doses - hyperoxaluria and the formation of urinary stones from calcium oxalate, damage to the glomerular apparatus of the kidneys.
Immune system disorders: the frequency is unknown - skin rash, rhinitis, anaphylactic reactions, bronchospasm, angioedema, the formation of an "aspirin triad" (bronchial asthma, polypous rhinosinusitis, and intolerance to acetylsalicylic acid and pyrazolone preparations).
Disorders of the liver and biliary tract: very rarely - Reye's syndrome (acute fatty degeneration of the liver with developed acute liver failure and encephalopathy); rarely, liver dysfunction (increased hepatic transaminases).
When these symptoms appear, it is recommended to stop taking the drug and immediately contact your doctor.
Children's age (up to 15 years); hypersensitivity to any component of the drug and other NSAIDs; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), gastrointestinal bleeding; inflammatory bowel disease in the acute stage; complete or incomplete combination of asthma, recurrent polyposis of the nasal mucosa and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs, including a history of; combined use of methotrexate at a dose of 15 mg per week or more; severe violations of the liver, kidneys; severe cardiac dysfunction; hemorrhagic diathesis; hemophilia, thrombocytopenia; deficiency of glucose-6-phosphate dehydrogenase; vitamin K deficiency; cerebrovascular or other bleeding; simultaneous administration of oral anticoagulants and acetylsalicylic acid in a dose exceeding 3 g per day; pregnancy (I and III trimesters), breastfeeding period.
With caution: with concomitant therapy with anticoagulants, gout, gastric ulcer and / or duodenal ulcer (in history), erosive gastritis, and propensity for gastrointestinal bleeding, impaired liver function, hypothrombinemia, hypovitaminosis K, anemia, condition of therapists, therapists, therapists, therapists, therapies, therapists, hepatitis, hypothrombinemia, hypovitaminosis K, anemia, conditions of therapists, therapists, therapists, therapists, hepatitis, hypothrombinemia, hypovitaminosis K, anemia, the condition of the chromic prostate glands, disorders of the liver, hypothrombinemia, hypovitaminosis K, anemia, prostatitis in the body (includingdysfunction of the heart, arterial hypertension), thyrotoxicosis, tendency to calcium-oxalate nephrolithiasis. Bronchial asthma, nasal polyposis, pollinosis, drug allergy, hypermenorrhea.
The combined use of aspirin and anticoagulants increases the risk of bleeding.
With the simultaneous use of the drug Aspirin and NSAIDs increase the main and side effects of the latter.
During treatment with Aspirin, the side effect of methotrexate is aggravated.
With the simultaneous use of Aspirin and oral hypoglycemic drugs - sulfonylurea derivatives, there is an increase in the hypoglycemic effect.
At simultaneous use with GKS increases the risk of gastrointestinal bleeding.
With the simultaneous use of Aspirin weakens the effect of spironolactone, furosemide, antihypertensive drugs, as well as anti-gout agents that promote the excretion of uric acid.
The prescription of antacid agents during treatment with Aspirin (especially in doses of more than 3 g for adults and more than 1.5 g for children) can cause a decrease in the high steady-state level of salicylate in the blood.
Pregnancy and Lactation
contraindicated in the I and III trimester and during breastfeeding. In the II trimester of pregnancy, you can assign occasionally and with caution.
The drug is not prescribed as an antipyretic for children under 15 years of age with acute respiratory infections caused by viral infections, due to the risk of Reye's syndrome. Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. Drug interactions are possible. Glucocorticosteroids, alcohol increase the damaging effects on the gastrointestinal mucosa. One dose of the drug contains 933 mg of sodium, which should be considered in patients receiving salt-free diet. In order to reduce the risk of increased bleeding, the drug should be canceled 4-8 days before the planned surgical intervention.
Symptoms: with mild intoxication, nausea, vomiting, epigastric pain, and also (especially in children and elderly patients) tinnitus, dizziness, headaches, loss of vision and hearing are possible.
With a significant overdose, incoherent thinking, confusion, drowsiness, collapse, tremor, shortness of breath, suffocation, dehydration, hyperthermia, coma, alkaline urine reaction, metabolic acidosis, respiratory (gas) alkalosis, and carbohydrate metabolism disorders appear.
Lethal dose of acetylsalicylic acid for adults - more than 10 g, for children - more than 3 g.
Treatment: Depending on the state of acid-base balance and electrolyte balance, solutions of sodium bicarbonate, sodium citrate or sodium lactate are infused.
- Brand name: Aspirin C
- Active ingredient: Acetylsalicylic acid, Ascorbic acid
- Dosage form: Effervescent pills
- Manufacturer: Bayer Pharma AG
- Country of Origin: Germany
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