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Pharmacological action - antispasmodic, analgesic.
Paracetamol is an analgesic, antipyretic and slightly anti-inflammatory.
The mechanism of action is associated with moderate inhibition of cyclooxygenase-1 and, to a lesser extent, cyclooxygenase-2 in peripheral tissues and the central nervous system, which results in inhibition of prostaglandin biosynthesis of pain sensitivity modulators, thermal control and inflammation.
The second component of dicycloverine hydrochloride is a tertiary amine, which has a relatively weak non-selective m-anticholinergic and direct myotropic antispasmodic effect on the smooth muscles of the internal organs.
At therapeutic doses, it causes effective relaxation of smooth muscles, which is not accompanied by side effects characteristic of atropine.
The combined effect of two componentsTrigana-D provides relaxation spasmodic smooth muscles of internal organs and the weakening of pain.
- Spasm of smooth muscles of internal organs.
- Intestinal colic.
- Hepatic colic.
- Renal colic.
- Migraine pain.
- Infectious and inflammatory diseases accompanied by fever.
1 tablet contains dicycloverine hydrochloride 20 mg, paracetamol 500 mg
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Dosage and Administration
It is applied inside.
Adults and children over 15 years: 1 tablet 2-3 times a day.
The maximum single dose for adults is 2 pills, 4 pills daily.
The duration of treatment without consultation with a doctor is not more than 5 days when prescribed as an anesthetic and 3 days as an antipyretic.
With prolonged use of the drug is necessary to control the picture of peripheral blood and the functional state of the liver.
Do not exceed the daily dose: its increase or longer treatment is possible only under medical supervision, because drug overdose can cause liver failure.
From the gastrointestinal tract
Dry mouth, loss of taste, loss of appetite, epigastric pain, constipation, increased activity of liver enzymes, usually without the development of jaundice, hepatonecrosis (dose-dependent effect).
Skin rash, pruritus, urticaria, Quincke edema, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome).
With moans of the central nervous system (it develops routinely when taking high doses)
Drowsiness, Dizziness, psychomotor agitation and disorientation.
From the endocrine system
Hypoglycemia, up to hypoglycemic coma.
From the side of blood formation organs
Anemia, methemoglobinemia (cyanosis, shortness of breath, pain in the heart), hemolytic anemia (especially for patients with gluco-6-phosphate dehydrogenase deficiency).
From the genitourinary system
Pyuria, urinary retention, interstitial nephritis, papillary necrosis.
By the organs of vision
Mydriasis blurred vision, accommodation paralysis, increased intraocular pressure.
From the reproductive system
- hypersensitivity to any component of Trigan-D;
- obstructive diseases of the gastrointestinal tract, hepatic and urinary tracts;
- severe ulcerative colitis;
- reflux esophacitis;
- the unstable state of the cardiovascular system in acute bleeding;
- yive gravis;
- children under 6 months
Amantadine, antipsychotic agents, benzodiazepines, MAO inhibitors, narcotic analgesics, nitrates and nitrites, sympathomimetics, tricyclic antidepressants, anticholinergics, corticosteroids; reduce - antacids.
Enhances the effects of digoxin.
Pregnancy and Lactation
Contraindicated in pregnancy and lactation.
With caution and under the supervision of a physician, the drug should be used in patients with impaired liver or kidney function, along with other anti-inflammatory and analgesic drugs, as well as anticoagulants and drugs that affect the central nervous system. When taking metoclopramide, domperidone, or colestiramine, you should also consult with your doctor.
Paracetamol distorts laboratory test results in the quantitative determination of plasma uric acid and glucose levels.
In order to avoid toxic damage to the liver, paracetamol should not be combined with the intake of alcoholic beverages, as well as be taken by persons prone to chronic alcohol consumption. The risk of liver damage increases in patients with alcoholic hepatosis.
Influence on ability to drive motor transport and control mechanisms:
When using the drug should refrain from potentially dangerous activities requiring increased concentration and speed of psychomotor reactions (driving and others.)
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Symptoms: tachycardia, tachypnea, fever, agitation, convulsions, epigastric pain, loss of appetite, anemia, thrombocytopenia, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, nephrotoxicity (papillary necrosis), hepatonecrosis
Treatment: stop taking the drug, do a gastric lavage, prescribe adsorbents, introduce agents that increase the formation of glutathione (acetylcysteine intravenously) and enhance conjugation reactions (methionine orally).
- Brand name: Trigan-D
- Active ingredient: Dicycloverine, Paracetamol
- Dosage form: Pills
- Manufacturer: Cadilla
- Country of Origin: India