Buy Benfogamma 150 dragee 60 pcs
  • Buy Benfogamma 150 dragee 60 pcs

Benfogamma [Benfotiamine]

Verwag Pharma
1365 Items
2019-09-19
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$35.65
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Clinical Pharmacology

Vitamin preparation. Benfotiamine is a fat soluble derivative of thiamine (vitamin B1). Thiamine is converted to active thiamine pyrophosphate and is included as a coenzyme in the pyruvate decarboxylase, alpha ketoglutarate decarboxylase complexes, which are involved in the oxidative decarboxylation of pyruvic acid and alpha ketoglutaric acid; transketolase is a pentose phosphate shunt enzyme.

Indications

Vitamin B1 deficiency, confirmed by clinical and biochemical studies, developing on the background of:

- insufficient and inadequate nutrition (beriberi disease);

- parenteral nutrition for a long time;

- hemodialysis;

- chronic alcoholism (alcoholic cardiomyopathy, Wernicke encephalopathy, Korsakov syndrome);

- increased need for vitamin B1.

Polyneuropathy due to vitamin B1 deficiency. Typical signs of such a deficiency are neurological disorders in the form of neuropathies with sensory impairments (pain, tingling, loss of sensation in the upper and lower extremities).

Composition

Excipients: microcrystalline cellulose - 122 mg, Povidone K30 - 8 mg, glycerides of fatty acids - 5 mg, colloidal silicon dioxide - 7 mg, carmellose sodium - 3 mg, talc - 10 mg.

The composition of the shell: shellac - 3 mg, sucrose - 70.875 mg, calcium carbonate - 66.479 mg, talc - 41.314 mg, acacia gum - 10.155 mg, corn starch - 7.34 mg, titanium dioxide - 10.932 mg, colloidal silicon dioxide - 4.404 mg, povidone K30 - 6.21 mg, macrogol 6000 - 1.597 mg, glycerol 85% - 2.262 mg, polysorbate 80 - 0.133 mg, mountain glycolic wax - 0.3 mg.

Benfotiamine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Benfogamma 150 Verwag Pharma Germany dragee
Benfogamma 150 Verwag Pharma Germany pills

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Benfogamma [Benfotiamine]

Dosage and Administration

Dibazol taken orally (2 hours before meals or 2 hours after meals) - 20-50 mg 2-3 times a day for 3-4 weeks or shorter courses.

In the treatment of diseases of the nervous system - 5 mg 1 time per day or every other day, the course - 5-10 doses.

Children under the age of 1 year old - 1 mg once a day, 1-3 years old - 2 mg, 4-8 years old - 3 mg, 9-12 years old - 4 mg, over 12 years old - 5 mg.

The course, if necessary, repeat after 3-4 weeks.

The course of treatment is 8-14 days.

Adverse reactions

Allergic reactions.
When used in high doses:

  • feeling hot
  • increased sweating
  • dizziness,
  • nausea,
  • headache.

Hypersensitivity.

Drug interactions

Warns an increase in OPSS due to non-selective beta-blockers.

Strengthens the hypotensive effect of hypotensive and diuretic drugs.

Phentolamine enhances the hypotensive effect of bendazole.

Pregnancy and Lactation

There are no contraindications.

Special instructions

Use Dibazol with care in elderly patients.

Not recommended for long-term treatment of hypertension, especially in elderly patients.

  • Brand name: Dibazol
  • Active ingredient: Bendazole
  • Dosage form: Pills
  • Manufacturer: Uralbiopharm
  • Country of Origin: Russia

Studies and clinical trials of Benfotiamine (Click to expand)

  1. Supramolecular self-assembly via inter-ligands hydrogen bonds in [Cu(H2O)2(NO3)2(tb)] (tb is thia­bendazole)
  2. Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes
  3. Thiamine and benfotiamine prevent increased apoptosis in endothelial cells and pericytes cultured in high glucose
  4. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro
  5. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
  6. Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis
  7. Oral benfotiamine plus α-lipoic acid normalises complication-causing pathways in type 1 diabetes
  8. Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes
  9. Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients
  10. High thiamine diphosphate concentrations in erythrocytes can be achieved in dialysis patients by oral administration of benfotiamine
  11. Effects of thiamine and benfotiamine on intracellular glucose metabolism and relevance in the prevention of diabetic complications
  12. Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose
  13. Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat
  14. The Defensive Effect of Benfotiamine in Sodium Arsenite-Induced Experimental Vascular Endothelial Dysfunction
  15. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
  16. LC Simultaneous Determination of Thioctic Acid, Benfotiamine and Cyanocobalamin in Thiotacid Compound Capsules
  17. Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations
  18. Benfotiamine relieves inflammatory and neuropathic pain in rats
  19. Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages
  20. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages
  21. Structure of benfotiamine hemihydrate
  22. Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-α
  23. UP-1.013: Effect of Benfotiamine in Expression of Phosphodiesterase 5 and Isoforms in Type 2 Diabetic Rat Kidney
  24. Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response

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