Buy Carnicetin capsules 295 mg 60 pcs
  • Buy Carnicetin capsules 295 mg 60 pcs


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Clinical Pharmacology

Acetyl-L-carnitine (ALA), a natural biologically active substance, is present under physiological conditions in the body in various organs and tissues, including the central nervous system, and is involved in the metabolism of fatty acids and carbohydrates. The pharmacological and biological effects of ALA are largely due to the metabolic effects of L-carnitine and the acetyl group that make up it. Acetyl-L-carnitine (ALA), a biologically active form of L-carnitine, a key substance in the process of catabolism of fats and the formation of energy in the body. ALA is synthesized in the brain tissue, liver and kidney from L-carnitine with the participation of the enzyme carnitine acetyltransferase. Since ALA supplies activated acetate directly to the matrix of mitochondria for the formation of acetyl CoA, which participates in the tricarboxylic acid cycle, without additional energy expenditure, it is an easily accessible substrate for starting energy-dependent mitochondrial metabolic processes. Due to the full-fledged energy supply of the body with less oxygen consumption by tissues, ALA protects brain tissue from ischemia.
Due to its structural similarity with acetylcholine, ALA has a cholinomimetic effect, and also exhibits neuroprotective properties. It increases the cellular concentration of aspartic and glutamic acid, as well as taurine, with prolonged use increases the density of N-methyl-D-aspartate - receptors in the hippocampus, cortex and striatum and prevents their density from decreasing in aging conditions. ALA enhances the effects of serotonin and also protects brain cells from the neurotoxic effects of ammonia and glutamate.
The results of experimental studies have shown that ALK has anti-anamnestic activity, the ability to improve learning processes, indicators of non-associative memory, to have a positive effect on mnestic functions in an experimental Alzheimer's disease model, without causing side effects of a sedative and muscle relaxant.
ALA increases energy production, being an easily accessible substrate for triggering energy-dependent metabolic processes in the mitochondria. Stimulates the synthesis of proteins and phospholipids for the construction of membranes, improves regeneration processes. In pathology, it has a neuroprotective effect, especially in relation to neurons and their organelles (mitochondria), as well as a neurotrophic effect by modulating the activity of nerve growth factor (NGF). It has antioxidant and membrane stabilizing effect. ALA can accelerate the regeneration of nerve cells in traumatic and endocrine injuries of peripheral nerves in experimental models of polyneuropathy in diabetes.
ALA has a noticeable effect on slowing the aging process by increasing the transport of fatty acids to mitochondria and maintaining their work at the level of a young organism. ALA can accelerate the regeneration of nerve cells in traumatic and endocrine injuries of peripheral nerves in experimental models of diabetes.



  • Initial Alzheimer's-type dementia (Alzheimer's disease) and cerebrovascular dementia;
  • Peripheral neuropathy of various etiologies;
  • Primary and secondary involutional syndromes on the background of vascular encephalopathy;
  • Decreased mental performance, to improve concentration and memory.


Acetylcarnitine hydrochloride (Carnicetine) 0.295 g
Excipients: microcrystalline cellulose (MCC); colloidal silicon dioxide (Aerosil A-300); magnesium stearate - to obtain the mass of the capsule content of 0.34 g.

Hard gelatin capsules: the composition of the capsules is gelatin; glycerol (glycerol); nipagin (methyl parahydroxybenzoate); nipazol (propyl parahydroxybenzoate); sodium lauryl sulfate; purified water, titanium dioxide.

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Dosage and Administration

For oral use. The single dose for adults is usually 1–4 caps., The daily dose is 6–12 caps. The course of treatment is 1–4 months.

Adverse reactions

Allergic reactions are possible; nausea, heartburn.


  • Individual hypersensitivity to the drug Carnicetine;
  • Age up to 18 years (efficacy and safety have not been established).

Drug interactions

Cases of drug interactions are not marked.

Pregnancy and Lactation

Special studies on the possibility of using during pregnancy and during breastfeeding have not been conducted; apply only if the intended benefit to the mother exceeds the risk to the fetus. At the time of treatment should stop breastfeeding.


Cases of overdose are not registered.

  • Brand name: Carnicetin
  • Active ingredient: Acetylcarnitine
  • Manufacturer: Piq-Pharma

Studies and clinical trials of Acetylcarnitine (Click to expand)

  1. Double-blind, placebo-controlled study ofL-acetylcarnitine for the treatment of hyperactive behavior in fragile X syndrome
  2. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: Involvement of the transcription factor Nrf2
  3. Acetylcarnitine and cholinergic receptors
  4. Quantification of Carnitine, Acetylcarnitine, and Total Carnitine in Tissues by High-Performance Liquid Chromatography: The Effect of Exercise on Carnitine Homeostasis in Man
  5. A simple radioisotopic assay of acetylcarnitine and acetyl-CoA at picomolar levels
  6. A preparation and purification of [1-14C]acetylcarnitine
  7. Conformations of carnitine and acetylcarnitine and the relationship to mitochondrial transport of fatty acids
  8. Crystal structures of carnitine and acetylcarnitine zwitterions: A structural hypothesis for mode of action
  9. Analytical method for urinary glutarylcarnitine, acetylcarnitine and propionylcarnitine with a carboxylic acid analyser and a reversed-phase column
  10. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes
  11. Enzymatic determination of acetylcarnitine for diagnostic applications
  12. Effects of intravenous L-acetylcarnitine on retinal oscillatory potentials
  13. Oxidation of acetate, acetyl CoA and acetylcarnitine by pea mitochondria
  14. Action ofl-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging
  15. Action ofl-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum
  16. Activity of L-carnitine and L-acetylcarnitine on cholinoceptive neocortical neurons of the rat in vivo
  17. Metabolic and physiological differences between zero-flow and low-flow myocardial ischemia: effects of L-acetylcarnitine
  18. Effects ofl-Acetylcarnitine on Cirrhotic Patients with Hepatic Coma: Randomized Double-Blind, Placebo-Controlled Trial
  19. Effect of In Vivol-Acetylcarnitine Administration on ATP-ases Enzyme Systems of Synaptic Plasma Membranes from Rat Cerebral Cortex
  20. High-performance liquid chromatographic determination of the enantiomers of carnitine and acetylcarnitine on a chiral stationary phase
  21. GABA-activated Chloride Currents of Postnatal Mouse Retinal Ganglion Cells are Blocked by Acetylcholine and Acetylcarnitine: How Specific are Ion Channels in Immature Neurons?
  22. Utilization of Citrate, Acetylcarnitine, Acetate, Pyruvate and Glucose for the Synthesis of Acetylcholine in Rat Brain Slices
  23. Incorporation of Acetate into Acetylcholine, Acetylcarnitine, and Amino Acids in the Torpedo Electric Organ

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