Dioxidine

Brand Biosynthesis

In stock 1407 Items

Available since: 2019-09-19

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Clinical Pharmacology

Dioxidine is a broad-spectrum antibacterial bactericidal drug.
Active in: Proteus vulgaris, Pseudomonas aeruginosa, Friedlander sticks, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp, Staphylococcus spp, Streptococcus spp, pathogen, pathogenic
It acts on bacteria strains resistant to other antibacterial agents, including antibiotics. It has no irritating effect. Perhaps the development of drug resistance of bacteria. Treatment of burns and purulent-necrotic wounds contributes to a more rapid cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and favorably affects the course of the wound process.

Indications

Wound and burn infections:
- Superficial and deep purulent wounds of various localization.
- Long-term unhealed wounds and trophic ulcers.
- Soft tissue phlegmon.
- Infected burns.
- Purulent wounds with osteomyelitis.
- Purulent processes in the pelvic tissue.

Composition

100 g of ointment contains: dioxidine - 5 g, polyethylene oxide-400 - 74.9 g, polyethylene oxide-1500 - 20 g, nipagin - 0.08 g, propyl paraoxybenzoic acid ester - 0.02 g.

Dioxidine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Dioxidine	Biosynthesis	Russia	ointment
Dioxidine	Novosibkhimpharm	Russia	solution

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Dosage and Administration

Locally. A thin layer is applied to the affected area once a day. Course up to 3 weeks.

Adverse reactions

Local reactions, near-edge dermatitis.

Contraindications

- Hypersensitivity.
- Adrenal insufficiency (including in history).
- Pregnancy.
- Lactation period.
Use with caution in renal failure.

Pregnancy and Lactation

If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding. Experimental studies have shown that Dioxidine has a teratogenic and embryotoxic effect, has mutagenic properties. Given this, women of childbearing age drug is prescribed only with the ineffectiveness of other antimicrobials.

Special instructions

For the prevention of adverse reactions it is recommended to prescribe antihistamines and calcium supplements. With the development of adverse reactions ointment should be canceled.
Patients with impaired renal function, the drug should be prescribed in smaller doses.