Furazolidone

Brand Anzhero-Sudzhensky HFZ

In stock 1006 Items

Available since: 2019-09-19

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Clinical Pharmacology

The drug belongs to antimicrobial and antiprotozoal agents. Possesses bacteriostatic action in relation to microbes. The mechanism of action is to disrupt the activity of certain enzyme systems of bacteria. Spectrum of action: gram-positive cocci (Streptococcus, Staphylococcus), gram-negative rods (Escherichia, Salmonella, Shigella, Proteus, Klebsiella, Enterobacter), protozoa (Lamblia). Of the causative agents of intestinal infections, the causative agents of dysentery, typhoid and paratyphoid are most sensitive. Resilience develops slowly.

Indications

- dysentery;

- paratyphoid;

- food toxicoinfection;

- giardiasis.

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Dosage and Administration

Orally, after eating, washing it down with plenty of liquid.
For dysentery, paratyphoid fever, foodborne toxicoinfections prescribed for adults 100-150 mg 4 times a day, after meals, for 5-10 days. Doses for children are reduced according to age.
The duration of treatment depends on the nature and severity of the infection. You can prescribe the drug in the same doses in cycles of 3-6 days with an interval of 3-4 days. It is not recommended to take the drug for more than 10 days.
When Trichomonas urethra is taken orally 100 mg 4 times a day for 3 days.
With giardiasis, adults are prescribed 100 mg 4 times a day. Children at the rate of 10 mg / kg per day in 3-4 doses.
Maximum doses for adults: single - 200 mg, daily - 800 mg.

Adverse reactions

Possible: nausea, vomiting, loss of appetite, allergic reactions in the form of skin rash.

Contraindications

- pregnancy and lactation;

- terminal stage of chronic renal failure;

- deficiency of glucose-6-dehydrogenase;

- children's age up to 1 year;

- increased individual sensitivity to the group of nitrofurans.

Drug interactions

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, therefore, their simultaneous reception is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephedrine, tyramine can cause a sharp increase in blood pressure.

Means, alkalizing urine, reduce the effect (accelerate the excretion of urine), acidifying - increase. Aminoglycosides and tetracycline enhance antimicrobial properties.
Increases blood depression against chloramphenicol and ristomycin.

Pregnancy and Lactation

During pregnancy, during lactation, taking the drug is contraindicated.

Special instructions

Increases sensitivity to the action of ethanol.

Drugs alkalinizing urine reduce the effect, and acidifying drugs increase it.

Aminoglycosides and tetracycline enhance antimicrobial properties.

During treatment, precautions should be observed, as well as when using monoamine oxidase inhibitors, namely: exclusion from the diet of products containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

For the prevention of neuritis with prolonged use must be combined with vitamins of group B.

Overdosage

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

Treatment: cancellation of drugs, taking large amounts of fluids, symptomatic therapy, antihistamine drugs, vitamins of group B.

Brand name: Furazolidone
Active ingredient: Furazolidone
Dosage form: pills of yellow or greenish-yellow color, flat-cylindrical with a chamfer.
Manufacturer: Anzhero-Sudzhensky HFZ
Country of Origin: Russia