Novigan®

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Novigan®

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Inside, 1 hour before or 3 hours after meals. In order to avoid irritating the stomach, you can take the drug immediately after a meal or drink milk.
In the absence of specific doctor's instructions, it is recommended to take SPAZGAN NEO for spastic pains, 1 tablet up to 3 times a day. The maximum daily dose of 3 pills. Do not exceed the specified dose!
The course of treatment with SPASGAN NEO, without consulting a doctor, should not exceed 5 days. A more prolonged use is possible under the supervision of a physician with control indicators of the peripheral blood picture and the functional state of the liver.

Adverse reactions

The frequency of side effects is classified according to the recommendations of the World Health Organization: characterized as very often - at least 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than <0.1%; very rarely, including individual posts - less than 0.01%.
In recommended doses, SPASGAN NEO does not cause side effects.
Co-side of the digestive system: often - NSAID-gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the mucous membrane of the gastrointestinal tract, which, in some cases, are complicated by perforation and bleeding; irritation and dryness of the oral mucosa, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, very rarely - pancreatitis, hepatitis, abnormal liver function, hepatotoxicity.
On the part of the respiratory system: rarely - shortness of breath, bronchospasm.
On the part of the senses: hearing impairment: rarely - hearing loss, ringing or tinnitus; visual impairment; infrequently - blurred vision, scotoma, dryness and irritation of the eye, conjunctival edema and eyelids (allergic origin), amblyopia, very rarely - accommodation paresis, toxic damage to the optic nerve.
From the central and peripheral nervous system: infrequently - headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, very rarely - confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases).
Since the cardiovascular system: infrequently - tachycardia, increased blood pressure; rarely heart failure.
On the part of the urinary system: infrequently - nephrotic syndrome (edema), oliguria, anuria, polyuria, proteinuria, cystitis, urine staining in red; rarely - acute renal failure, allergic nephritis.
Allergic reactions: infrequently - skin rash (usually erythematous or urticaria), pruritus, very rarely - angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme erythema (including Symptom syndrome, and also Symptom syndrome; epidermal necrolysis (Lyell's syndrome), allergic rhinitis.
On the part of the blood-forming organs: infrequently - thrombocytopenia and thrombocytopenic purpura, very rarely - anemia (including hemolytic, aplastic), agranulocytosis, leukopenia, eosinophilia.
Other: very rarely - increased or decreased sweating.
From laboratory indicators: bleeding time (may increase), serum glucose concentration (may decrease), creatinine clearance (may decrease), hematocrit or hemoglobin (may decrease), serum creatinine concentration (may increase), hepatic transaminase activity (may increase ).
If taking the drug has caused a change in your normal condition, stop taking it and consult a doctor immediately.

Contraindications

Hypersensitivity to any of the ingredientsincluded in the preparation; erosive and ulcerative changes of the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding; inflammatory bowel disease in the acute phase, including ulcerative colitis; anamnestic data on the attack of bronchial obstruction, rhinitis, urticaria, after taking acetylsalicylic acid or another nonsteroidal anti-inflammatory drug - NSAIDs (complete or incomplete intolerance syndrome acetylsalicylic acid - rhinosinusitis, urticaria, nasal polyps, bronchial asthma); liver failure or active liver disease; renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease; confirmed hyperkalemia; hemophilia and other bleeding disorders including hypocoagulation), hemorrhagic diathesis; period after coronary artery bypass surgery; acute intermittent porphyria; granulocytopenia; blood disorders; deficiency of glucose b-phosphate dehydrogenase; tachyarrhythmia; angle-closure glaucoma; diseases of the optic nerve; prostatic hyperplasia; intestinal obstruction; pregnancy and breastfeeding, age up to 16 years.
Carefully
Advanced age, congestive heart failure, cerebrovascular disease, hypertension, coronary heart disease, dyslipidemia, hyperlipidemia, diabetes mellitus, peripheral arterial disease, nephrotic syndrome, creatinine clearance of less than 30-60 ml / min, hyperbilirubinemia, gastric ulcer and duodenal ulcer ( history), the presence of Helicobacter pylori infection, gastritis, enteritis, colitis, prolonged use of NSAIDs, blood diseases of unknown etiology (leukopenia, anemia), smoking, frequent use alcohol (alcoholism), severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (citrate (eg, prednisolone), selective serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors) , paroxetine, sertraline).

Drug interactions

In therapeutic doses, the drug SPASGAN NEO does not enter into significant interactions with widely used drugs.
The inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic anti-depressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.
Reduces the hypotensive activity of vasodilators and the natriuretic effect of furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricosuric drugs. It enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).
Strengthens the side effects of mineral corticosteroids, glucocorticosteroids (increases the risk of gastrointestinal bleeding), estrogen, ethanol. With simultaneous use of the drug with hypoglycemic agents for oral administration may enhance their effect, thereby contributing to the risk of hypoglycemia.
Antacids and colestyramine reduce the absorption of ibuprofen.
Increases blood concentration of digoxin, lithium preparations and methotrexate.
Enhances the action of M-anticholinergics, H1-histamine blockers, butyrophenones, phenothiazines, amantadine and quinidine.
The simultaneous appointment of other NSAIDs increases the frequency of side effects.
Caffeine enhances the analgesic (analgesic) effect.
With the simultaneous appointment reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients who receive small doses of acetylsalicylic acid as an antiplatelet agent, after starting the administration of SPASGAN NEO.
Cefamandol, cefoperazone, cefotetan, valproic acid, plykamycin increase the incidence of hypoprothrombinemia with simultaneous appointment.
Myelotoxic drugs increase the hematotoxicity of the drug.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.
Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.

Special instructions

Overdosage