Buy Spazgan neo pills 400 mg + 5 mg + 0.1 mg 20 pcs
  • Buy Spazgan neo pills 400 mg + 5 mg + 0.1 mg 20 pcs


975 Items
Dosage form
Brand & Manufacturer
Package Size
  • done All payments are SSL encrypted
  • done Full Refund if you haven't received your order
  • done International shipping to the USA, UK and Europe

Clinical Pharmacology

The combined drug has analgesic, anti-inflammatory and antispasmodic action. Suppresses prostaglandin synthesis (Pg). The composition of the drug includes non-steroidal anti-inflammatory agent ibuprofen, myotropic antispasmodic pitofenone hydrochloride and m-antinox blocking agent of the central and peripheral action of fenpiverinium bromide.
Ibuprofen is a derivative of phenylpropionic acid. It has analgesic, anti-inflammatory and antipyretic effects. The main mechanism of action is the inhibition of the biosynthesis of prostaglandins - modulators of pain sensitivity, thermoregulation and inflammation in the central nervous system and peripheral tissues. In women with primary dysmenorrhea, an increased level of prostaglandins in the myometrium reduces, thereby reducing intrauterine pressure and the frequency of uterine contractions.
Pitofenone hydrochloride, like papaverine, has a direct myotropic effect on the smooth muscles of the internal organs and causes its relaxation.
Fenpiverine bromide due to its m-holinoblokiruyuschego action has an additional relaxing effect on smooth muscles.
The combination of the three components of the drug leads to mutual enhancement of their pharmacological action.
The components of the preparation SPASGAN NEO are well absorbed in the gastrointestinal tract. The peak plasma concentration is reached approximately 1-2 hours after taking the drug. The main component of the drug ibuprofen is 99% bound to plasma proteins, it can accumulate in the synovial fluid, is metabolized in the liver and excreted by 90% in the urine as metabolites and conjugates. A small part of the drug is excreted in the bile. The half-life of plasma is 2 hours.


- Weak and moderately pronounced pain in spasms of smooth muscles of the internal organs: renal and biliary colic, biliary dyskinesia, intestinal colic.
- Gynecological diseases: dysmenorrhea.
- Headache, including migraine nature.
- Short-term symptomatic treatment of pain in the joints, neuralgia, sciatica, myalgia.


Active substances: ibuprofen 400.0 mg, pitofenone hydrochloride 5.0 mg, fenpiverinium bromide 0.1 mg.
Excipients: corn starch 88.0 mg, microcrystalline cellulose 85.9 mg, sodium carboxymethyl starch (type A) 14.7 mg, alginic acid 10.6 mg, disodium edetate dihydrate 0.6 mg, povidone (PVP K-90) 11.0 mg, colloidal silicon dioxide (aerosil 200) 7.0 mg, croscarmellose sodium 4.7 mg, sodium lauryl sulfate 2.4 mg, magnesium stearate 5.0 mg, talc 5.0 mg;
excipients (shell): opadry II 85668918 white 19.2 mg: polyvinyl alcohol 7.4 mg, titanium dioxide 5.76 mg, talc 3.36 mg, macrogol 2.1 mg, soy lecithin 0.58 mg.

Novigan® is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Spazgan neo wockhardt India pills
Novigan Dr. Reddy`s India pills

No customer reviews for the moment.

Write your review

Write your review


Dosage and Administration

Inside, 1 hour before or 3 hours after meals. In order to avoid irritating the stomach, you can take the drug immediately after a meal or drink milk.
In the absence of specific doctor's instructions, it is recommended to take SPAZGAN NEO for spastic pains, 1 tablet up to 3 times a day. The maximum daily dose of 3 pills. Do not exceed the specified dose!
The course of treatment with SPASGAN NEO, without consulting a doctor, should not exceed 5 days. A more prolonged use is possible under the supervision of a physician with control indicators of the peripheral blood picture and the functional state of the liver.

Adverse reactions

The frequency of side effects is classified according to the recommendations of the World Health Organization: characterized as very often - at least 10%; often - not less than 1%, but less than 10%; infrequently - not less than 0.1%, but less than 1%; rarely - not less than 0.01%, but less than <0.1%; very rarely, including individual posts - less than 0.01%.
In recommended doses, SPASGAN NEO does not cause side effects.
Co-side of the digestive system: often - NSAID-gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the mucous membrane of the gastrointestinal tract, which, in some cases, are complicated by perforation and bleeding; irritation and dryness of the oral mucosa, pain in the mouth, ulceration of the mucous membrane of the gums, aphthous stomatitis, very rarely - pancreatitis, hepatitis, abnormal liver function, hepatotoxicity.
On the part of the respiratory system: rarely - shortness of breath, bronchospasm.
On the part of the senses: hearing impairment: rarely - hearing loss, ringing or tinnitus; visual impairment; infrequently - blurred vision, scotoma, dryness and irritation of the eye, conjunctival edema and eyelids (allergic origin), amblyopia, very rarely - accommodation paresis, toxic damage to the optic nerve.
From the central and peripheral nervous system: infrequently - headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, very rarely - confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases).
Since the cardiovascular system: infrequently - tachycardia, increased blood pressure; rarely heart failure.
On the part of the urinary system: infrequently - nephrotic syndrome (edema), oliguria, anuria, polyuria, proteinuria, cystitis, urine staining in red; rarely - acute renal failure, allergic nephritis.
Allergic reactions: infrequently - skin rash (usually erythematous or urticaria), pruritus, very rarely - angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm or dyspnea, fever, erythema multiforme erythema (including Symptom syndrome, and also Symptom syndrome; epidermal necrolysis (Lyell's syndrome), allergic rhinitis.
On the part of the blood-forming organs: infrequently - thrombocytopenia and thrombocytopenic purpura, very rarely - anemia (including hemolytic, aplastic), agranulocytosis, leukopenia, eosinophilia.
Other: very rarely - increased or decreased sweating.
From laboratory indicators: bleeding time (may increase), serum glucose concentration (may decrease), creatinine clearance (may decrease), hematocrit or hemoglobin (may decrease), serum creatinine concentration (may increase), hepatic transaminase activity (may increase ).
If taking the drug has caused a change in your normal condition, stop taking it and consult a doctor immediately.


Hypersensitivity to any of the ingredientsincluded in the preparation; erosive and ulcerative changes of the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding; inflammatory bowel disease in the acute phase, including ulcerative colitis; anamnestic data on the attack of bronchial obstruction, rhinitis, urticaria, after taking acetylsalicylic acid or another nonsteroidal anti-inflammatory drug - NSAIDs (complete or incomplete intolerance syndrome acetylsalicylic acid - rhinosinusitis, urticaria, nasal polyps, bronchial asthma); liver failure or active liver disease; renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease; confirmed hyperkalemia; hemophilia and other bleeding disorders including hypocoagulation), hemorrhagic diathesis; period after coronary artery bypass surgery; acute intermittent porphyria; granulocytopenia; blood disorders; deficiency of glucose b-phosphate dehydrogenase; tachyarrhythmia; angle-closure glaucoma; diseases of the optic nerve; prostatic hyperplasia; intestinal obstruction; pregnancy and breastfeeding, age up to 16 years.
Advanced age, congestive heart failure, cerebrovascular disease, hypertension, coronary heart disease, dyslipidemia, hyperlipidemia, diabetes mellitus, peripheral arterial disease, nephrotic syndrome, creatinine clearance of less than 30-60 ml / min, hyperbilirubinemia, gastric ulcer and duodenal ulcer ( history), the presence of Helicobacter pylori infection, gastritis, enteritis, colitis, prolonged use of NSAIDs, blood diseases of unknown etiology (leukopenia, anemia), smoking, frequent use alcohol (alcoholism), severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid, clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (citrate (eg, prednisolone), selective serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors (citrate) (citreous serotonin reuptake inhibitors) , paroxetine, sertraline).

Drug interactions

In therapeutic doses, the drug SPASGAN NEO does not enter into significant interactions with widely used drugs.
The inducers of microsomal oxidation enzymes in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic anti-depressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.
Reduces the hypotensive activity of vasodilators and the natriuretic effect of furosemide and hydrochlorothiazide.
Reduces the effectiveness of uricosuric drugs. It enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (which increases the risk of bleeding).
Strengthens the side effects of mineral corticosteroids, glucocorticosteroids (increases the risk of gastrointestinal bleeding), estrogen, ethanol. With simultaneous use of the drug with hypoglycemic agents for oral administration may enhance their effect, thereby contributing to the risk of hypoglycemia.
Antacids and colestyramine reduce the absorption of ibuprofen.
Increases blood concentration of digoxin, lithium preparations and methotrexate.
Enhances the action of M-anticholinergics, H1-histamine blockers, butyrophenones, phenothiazines, amantadine and quinidine.
The simultaneous appointment of other NSAIDs increases the frequency of side effects.
Caffeine enhances the analgesic (analgesic) effect.
With the simultaneous appointment reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients who receive small doses of acetylsalicylic acid as an antiplatelet agent, after starting the administration of SPASGAN NEO.
Cefamandol, cefoperazone, cefotetan, valproic acid, plykamycin increase the incidence of hypoprothrombinemia with simultaneous appointment.
Myelotoxic drugs increase the hematotoxicity of the drug.
Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.
Drugs that block tubular secretion, reduce excretion and increase the plasma concentration of ibuprofen.

Special instructions

With long-term use, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys.
To reduce the risk of adverse events from the gastrointestinal tract, a minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring is shown, including esophagogastroduodenoscopy, a blood test with hemoglobin and hematocrit, and fecal occult blood analysis.
If it is necessary to determine the 17-ketosteroids, the drug should be canceled 48 hours before the study.
During the period of treatment should refrain from taking alcohol.
The effect of a medicinal product for medical use on the ability to drive vehicles, machinery
During the period of treatment, the patient should refrain from practicing potentially hazardous activities that require increased concentration and psychomotor speed.


Do not exceed the specified dose. If you exceed the dose, consult a doctor or the nearest medical facility immediately. Take the product package with you.
Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, low blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory failure.
Treatment: gastric lavage (only within an hour after ingestion), activated carbon, alkaline drinking, forced diuresis, symptomatic therapy (correction of the acid-base state, blood pressure). There is no specific antidote.

  • Brand name: Novigan
  • Active ingredient: Ibuprofen, Pitofenone, Fenpiverinium bromide

Studies and clinical trials of Novigan (Click to expand)

  1. F/A

8 other products in the same category: