Divaza®

Pharmacological group: Antihypoxant, antioxidant, nootropic, angioprotective agent.
Pharmaceutical action: Divaza®a - a combined drug.
Antibodies to the brain-specific protein S-100 have an antioxidant, antihypoxant, neuroprotective, anxiolytic effect. Modify the functional activity of the protein S-100, carrying out the conjugation of information and metabolic processes in the brain. They have a membranotropic action, causing a decrease in amplitude and suppression of the generation of an action potential; modulate synaptic plasticity in the limbic structures of the brain, hippocampus, reticular formation; contribute to enhancing the inhibitory effects of GABA in the central nervous system. They exhibit sigma 1 receptor agonist properties in vitro.
Inhibit lipid peroxidation.
They have a normalizing effect on the integrative activity of the brain, which is manifested by a wide range of balanced psychopharmacological effects: antidepressant, anxiolytic, neuroprotective, antiasthenic, antiamnesic.
Antibodies to endothelial NO-synthase increase the activity of the enzyme endothelial NO-synthase, restore the production of endothelium nitric oxide (NO), eliminate endothelial dysfunction, have an endothelium-protective effect, affect NO-dependent vasodilation.
Experimentally shown stimulating effect of Divaza® on reparative processes in the focus of ischemic brain damage.
The combined use of the drug components is accompanied by an increase in the neuroprotective activity of antibodies to S-100 protein, an increase in the vegetative stabilizing effect, normalization of the vegetative status, a synergistic effect of both components on neuronal plasticity and, consequently, an increase in brain resistance to toxic effects; improves the integrative activity and restores the inter-hemispheric connections of the brain, helps to eliminate cognitive impairments, stimulates reparative processes and accelerates the restoration of the functions of the central nervous system, improves mental performance, restores the learning and memory processes, normalizes somatovegetative manifestations, increases cerebral blood flow.
Divaza®a, as well as its components, does not have a sedative and muscle relaxant effect, does not cause addiction and addiction.
Pharmacokinetics: The sensitivity of modern physico-chemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry) does not allow to evaluate the content of ultra-low doses of antibodies in biological fluids, organs and tissues, which makes it technically impossible to study the pharmacokinetics of the drug Divaza®.