Phenibut is a potent anxiolytic drug with nootropic properties. It was developed in the Soviet union as a non-sedating tranquilizer for astronauts. Phenibut is also widely used as an anxiety supplement.

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Phenibut is a nootropic drug with pronounced anxiolytic action.

The drug was first synthesized in 1960’s by the soviet scientists, in attempt to create non-sedative anxiolytic drug for astronauts, that would not impair cognitive and working performance.

Phenibut currently approved for medical use in Russia and other Post-soviet countries to treat various conditions. The official indications for use include chronic fatigue, anxiety disorders, tics and stuttering in children, alcohol withdrawal syndrome, Meniere’s disease and vertigo. Phenibut is also widely used worldwide as a dietary supplement for anxiety, though it should be used responsibly as it may be addictive if taken long-term in excessive dosages.

Phenibut is a phenyl derivative of GABA (gamma-Aminobutyric acid) and PEA (phenethylamine). GABA is a major inhibitory neurotransmitter in the human brain and is targeted by most anxiolytic drugs. However, the GABA itself does not produce anxiolytic effect if administered exogenously, since its molecule cannot penetrate the blood brain barrier. Unlike GABA, Phenibut is able to cross blood brain barrier and produce therapeutic effect on the brain.

The drug enhances GABAergic neurotransmission and produce anxiolytic effect without causing sedation or impairing cognition. More than that, Phenibut does have psychostimulant effect and is shown to improve cognitive functions rather than impairing them.

If you want know more about mechanism of action of Phenibut and its pharmacological effects, you can read a comprehensive article here.

Phenibut is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Phenibut Usolye-Sibirsky HFZ Russia pills
Phenibut Ozon Russia pills
Phenibut Moscow Endocrine Plant Russia pills
Anvifen Pharmproject Russia capsules
Noofen Olainfarm Latvia capsules

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Dosage and Administration

For oral use. after eating 2-3 week courses. Adults: 250-500 mg 3 times a day. If necessary, further daily dose is increased to 2500 mg. Children from 2 to 8 years old - 50-100 mg each; from 8 to 14 years - 250 mg 3 times a day. A single maximum dose in adults is 750 mg, in persons older than 60 years, 500 mg, in children under 8 years old, 150 mg, and from 8 to 14 years, 250 mg.
For the relief of alcohol withdrawal syndrome, in the first days of treatment, 250-500 mg 3 times a day and at night 750 mg are prescribed in the first days of treatment, with a gradual decrease in the daily dose to the usual for adults.
For the treatment of dizziness with dysfunctions of the vestibular apparatus and Meniere's disease, 250 mg is prescribed 3 times a day for 14 days.
For the prevention of motion sickness, a dose of 250-500 mg is taken once 1 hour before the expected start of rolling or when the first mild symptoms of motion sickness appear. The counteracting effect of Phenibut pills is enhanced by increasing the dose of the drug. At the onset of pronounced manifestations of seasickness (vomiting, etc.), the intake of Fenibut pills inside is ineffective even in doses of 750-1000 mg.

Adverse reactions

Drowsiness, nausea. Increased irritability, agitation, anxiety, dizziness, headache (at the first dose), allergic reactions (skin rash, itching).


Individual intolerance, pregnancy (1 trimester), breastfeeding, children under 2 years.
With caution in erosive and ulcerative lesions of the gastrointestinal tract, liver failure.

Drug interactions

In order to mutually potentiate, Phenibut can be combined with other psychotropic drugs, reducing the doses of Phenibut and the drugs that are combined with it. Lengthens and strengthens the effect of sleeping pills, narcotic, neuroleptic and anticonvulsant drugs, alcohol. There is evidence of an increase in antiparkinsonian drugs under the influence of the drug Phenibut.

Special instructions

With prolonged use, it is necessary to monitor indicators of liver function and the picture of peripheral blood. It is necessary to refrain from potentially hazardous activities that require increased attention.


Increased symptoms of side effects: severe drowsiness, nausea, vomiting, fatty liver (taking more than 7 g), eosinophilia, lowering blood pressure, impaired renal function. First aid - gastric lavage, taking activated charcoal and conducting symptomatic therapy.

  • Brand name: Phenibut
  • Active ingredient: Aminophenylbutyric acid
  • Dosage form: Pills.
  • Manufacturer: Usolye-Sibirsky HFZ
  • Country of Origin: Russia

Studies and clinical trials of Phenibut (Click to expand)

  1. Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography–tandem mass spectrometry
  2. Comparative Study of Immunocorrective Activity of Phenibut and Its Organic Salts in Experimental Immunodeficiency
  3. Effects of the GABA receptor agonist phenibut on behavior and respiration in rabbits in emotionally negative situations
  4. Effects of the GABA Receptor Agonist Phenibut on Spike Activity and Interactions between Neocortex and Hippocampus Neurons in Emotionally Negative Situations
  5. Development of a chromatographic method for quantitative analysis of phenibut in biological samples
  6. Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug
  7. Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions: Efficient Organocatalytic Syntheses of (S)-Baclofen, (R)-Baclofen and (S)-Phenibut
  8. Corrigendum: Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions: Efficient Organocatalytic Syntheses of (S)-Baclofen, (R)-Baclofen and (S)-Phenibut
  9. ChemInform Abstract: Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions: Efficient Organocatalytic Syntheses of (S)-Baclofen, (R)-Baclofen and (S)-Phenibut.
  10. Ionic mechanisms of the effect of phenibut and gaba not associated with a change in the function of the chloride channels
  11. Comparative pharmacological activity of optical isomers of phenibut
  13. EEG response to phenibut therapy in hyperactive children
  14. Phenibut, the Appearance of Another Potentially Dangerous Product in the United States
  15. Psychotic symptoms during phenibut (beta-phenyl-gamma-aminobutyric acid) withdrawal
  16. Highly Enantioselective Michael Addition of Nitroalkanes to Enones and Its Application in Syntheses of (R)-Baclofen and (R)-Phenibut
  17. Effects of Phenibut and Citrocard on Non-Competitive and Competitive Behavior during Provoked Aggression in Animals
  18. Acute behavioural disturbance associated with phenibut purchased via an internet supplier
  19. R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects
  20. Analytically confirmed recreational use of Phenibut (β-phenyl-γ-aminobutyric acid) bought over the internet
  21. Phenibut abuse
  22. The neuroprotective effects of R-phenibut after focal cerebral ischemia
  23. Optical isomers of phenibut inhibit [H3]-Gabapentin binding in vitro and show activity in animal models of chronic pain
  24. Phenibut overdose

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