Sympathyl®
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Clinical Pharmacology
The drug has a sedative effect, eliminates the state of anxiety and the associated autonomic disorders, tachycardia and sleep disorders. Biologically active substances of hawthorn extract - triterpene compounds and flavonoids have an antispasmodic effect, selectively expanding the heart and brain vessels, reduce the excitability of the central nervous system and myocardium.
Eschsoltsii extract has anxiolytic, sedative effect, reduces the time of falling asleep and improves the quality of sleep in mild forms of dissomnia. Alkaloids in the proscopic group escholcii increase the in vitro association of gamma-aminobutyric acid and brain receptors sensitive to it.
Magnesium improves the regulation of the transmembrane exchange of sodium and potassium ions, is an antagonist of calcium ions, reduces the ability to conduct excitation at the neuromuscular synapses, to reduce the smooth and cross - striped muscles; also has a neurosedative, antispasmodic and anxiolytic effects.
Pharmacokinetics
Magnesium oxide in the stomach is converted to magnesium chloride, which is absorbed in the small intestine using a passive suction mechanism, the absorption level does not exceed 50%. Excretion of magnesium is mainly carried out with urine. The action of the components is difficult for kinetic observations.
Indications
The states of emotional stress and stress, accompanied by increased excitability, anxiety, increased irritability, anxiety, fear, increased fatigue, palpitations; sleep disturbance (mild form).
Composition
1 tablet, film coated contains:
active substances: eschsoltsii dry extract 20.0 mg, hawthorn extract dry 75.0 mg, magnesium oxide 124.35 mg, equivalent to elemental magnesium 75.0 mg;
Excipients:microcrystalline cellulose - 122.0 mg, sodium carboxymethyl starch - 15.0 mg, micronized stearic acid - 3.65 mg.
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Dosage and Administration
For oral administration.
On 2 pills 2 times a day (in the morning and in the evening) to food, washing down with water.
Duration of treatment is 3-4 weeks.
The interval between courses of treatment is 3 weeks.
Adverse reactions
From the gastrointestinal tract: diarrhea, epigastric pain.
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.
Contraindications
- Hypersensitivity to the components of the drug Cutie,
- severe renal insufficiency (creatinine clearance below 30 ml / min),
- age up to 18 years.
Drug interactions
It is not recommended to combine the drug Sypytil with drugs containing quinidine, because renal excretion of quinidine is reduced due to alkalization of urine and an overdose may develop (due to an increase in the concentration of quinidine in the blood plasma).
Pregnancy and Lactation
Not recommended for use during pregnancy and breastfeeding.
Special instructions
The patient should be warned about the need to inform the doctor about the aggravation of any of the side effects indicated in the instructions or about the appearance of other side effects not indicated in the instructions.
Influence on ability to drive motor transport and control mechanisms
During the period of treatment, care should be taken when engaging in potentially hazardous activities that require increased concentration of attention and psychomotor speed (including driving, working with moving mechanisms).
Overdosage
Taking large doses of the drug can lead to urinary retention. Treatment: rehydration, forced diuresis. In case of kidney failure, hemodialysis or peritoneal dialysis is necessary.
- Brand name: Sympathyl
- Active ingredient: Dry extract, Hawthorn dry extract, Magnesium oxide
- Dosage form: Film Coated pills
- Manufacturer: Innotera Shuzi
- Country of Origin: France