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Pharmacotherapeutic group: antiseptic. ATH code: А01АВ12. Pharmacodynamics The antimicrobial effect of Hexoral® is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist). The drug has a broad spectrum of antibacterial and antifungal effects, in particular against gram-positive bacteria and fungi of the genus Candida, however, Hexoral® can also have an effect in the treatment of infections caused by, for example, Pseudomonas aeruginosa or Proteus spp. At a concentration of 100 mg / ml, the drug inhibits most strains of bacteria. The development of sustainability was not observed. Hexetidine has a weak anesthetic effect on the mucous membrane. The drug has an antiviral effect against influenza A viruses, respiratory syncytial virus (PC virus), herpes simplex virus type 1, affecting the respiratory tract. Pharmacokinetics Hexetidine adheres very well to the mucous membrane and is practically not absorbed. After a single application of the active substance, traces of it are found on the mucous membrane of the gums for 65 hours. In dental plaque, active concentrations persist for 10–14 hours after application.
As a symptomatic remedy. Symptomatic treatment of inflammatory and infectious diseases of the oral cavity and larynx: - tonsillitis, sore throat (incl. Pout – Vincent’s sore throat, sore throat of the lateral ridges), pharyngitis, gingivitis, stomatitis, glossitis, periodontal disease; - fungal diseases; prevention of infectious complications before and after surgical interventions on the oral cavity and larynx and injuries, including prevention of alveoli infection after tooth extraction; oral hygiene, including and to eliminate unpleasant smell from the mouth.
100 ml of the preparation contain: active ingredient - hexatidine - 0.200 g; Excipients: polysorbate 80 - 1.400 g, citric acid monohydrate - 0.070 g, sodium saccharinate - 0.040 g, levomenthol - 0.070 g, eucalyptus of the twigous leaves oil - 0.0011 g, sodium calcium edetate - 0.100 g, ethanol 96% - 4.333 g, sodium hydroxide - qs to pH 5.5 ± 0.2, purified water - q.s. up to 100 ml, nitrogen - q.s. up to 5 bar.
Hexetidine is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Hexoral||Tamar Orleans||France||spray can|
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Dosage and Administration
Locally. Children from 3 to 6 years: use of the drug is possible after consultation with a medical professional. Adults and children over 6 years old: treat the affected areas during breath holding, 1 injection for 1-2 seconds, 2 times a day. Hexetidine adheres to the mucous membrane and thus gives a lasting effect. In this regard, the drug should be used after meals.
Adverse reactions identified during post-registration use of the drug were classified as follows: very frequent (? 1/10), frequent (? 1/100, <1/10), not frequent (? 1/1000, <1/100) , rare (? 1/10000, <1/1000), very rare (<1/10000), the frequency is unknown (the frequency of occurrence cannot be estimated based on the available data). Immune system disorders. Very rarely: hypersensitivity reactions (including urticaria), angioedema. Nervous system disorders. Very rarely: agevziya, dysgeusia. Disturbances from the respiratory system, organs of the chest and mediastinum. Very rarely: cough, shortness of breath, due to the appearance of a hypersensitivity reaction. Violations of the gastrointestinal tract. Very rarely: dry mouth, dysphagia, nausea, increased salivary glands, vomiting. General disorders and disorders at the site of administration. Very rarely: reactions at the site of application (including irritation of the oral mucosa and pharynx, burning sensation, oral paresthesia, discoloration of the tongue, discoloration of teeth, inflammation, blistering and ulceration). If any side effects indicated in the instructions are aggravated or you notice other side effects, it is recommended to consult a doctor.
- Hypersensitivity to any of the components of the drug; - erosive-desquamous lesions of the oral mucosa; - children's age up to 3 years.
Pregnancy and Lactation
There is no information about any undesirable effects of Hexoral® during pregnancy and during breastfeeding. However, before prescribing Hexoral® to pregnant or lactating women, the doctor should carefully weigh the benefits and risks of treatment, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.
It is unlikely that hexatidine may have a toxic effect when used according to the instructions for use of the drug. Ingestion of a large amount of a preparation containing ethanol may result in signs / symptoms of alcohol intoxication. For any cases of overdose, consult a physician immediately. Symptomatic treatment, as in alcohol intoxication. Gastric lavage is necessary within 2 hours after swallowing the excess dose.
- Brand name: Hexoral
- Active ingredient: Hexetidine
- Dosage form: Aerosol for local use 0.2%. On 40 ml of a preparation in an aluminum aerosol cylinder with an internal varnish covering. On 1 aerosol container complete with one nozzle sprayer or four nozzles sprayers of different color together with the application instruction in a cardboard pack.
- Manufacturer: Tamar Orleans
- Country of Origin: France
- Availability of drugs in the presence of surface-active agents II effects of some oxyethylene oxypropylene polymers on the biological activity of hexetidine
- Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine : Relevance to mode of action
- The effect on early plaque formation, gingivitis and salivary bacterial counts of mouthwashes containing hexetidine/zinc, aminefluoride/tin or chlorhexidine
- The effect of hexetidine spray on dental plaque following periodontal surgery
- Allergic contact dermatitis due to the fungicide hexetidine
- Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis
- The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review
- The Effects of Hexetidine (Oraldene™) on the Adherence of Candida Albicans to Human Buccal Epithelial Cells In Vitro and Ex Vivo and on In Vitro Morphogenesis
- Physicochemical Characterization of Hexetidine-Impregnated Endotracheal Tube Poly(vinyl Chloride) and Resistance to Adherence of Respiratory Bacterial Pathogens
- Determination of the Salivary Retention of Hexetidine In-vivo by High-performance Liquid Chromatography
- On-column interactions in the direct GLC assay of hexetidine
- Effects of proprietary oral rinses containing chlorhexidine, hexetidine and benzydamine on the proliferation of human buccal epithelial cells in culture
- Uncoupling of mitochondrial oxidative phosphorylation by hexetidine
- Inhibition of oxygen consumption in human erythrocytes by hexetidine
- Inhibition of dehydrogenases of human leukocytes by hexetidine
- Serratia marcescens nosocomial outbreak due to contamination of hexetidine solution
- The effect of hexetidine and triclosan on the curing and mechanical properties of silicone elastomer
- Relationship between protein and nucleic acid synthesis in Pseudomonas azotogensis grown in hexetidine
- The abnormal pattern of protein synthesis in Pseudomonas azotogensis in the presence of hexetidine
- Deodorization and healing: Hexetidine in periodontal surgery
- Nitrosation of the antimicrobial drug hexetidine: Nitrosamines derived from a triamine decomposition product
- Synergistic Inhibitory Effect of Zinc and Hexetidine on in vitro Growth and Acid Production of Streptococcus mutans
- Hexetidine mouthrinse in the management of minor aphthous ulceration and as an adjunct to oral hygiene
- The Nitrosation of Hexetidine and Hexedine: Characterization of the Major Nitrosamine from Common Antimicrobial Agents