Sulfanilamide
Tula pharmaceutical factory
705 Items
2019-09-19
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Clinical Pharmacology
Antimicrobial bacteriostatic agent, sulfanilamide. The mechanism of action of Streptocide is due to competitive antagonism with PABA, inhibition of dihydropteroate synthetase, impaired synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines. It is active against Gram-positive and Gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces isis, I, I, Iersinia pestis, Idinthis isthis, Istinicis, Israel, etc., Actinomy isis, I, I, Iersinia pestis; When applied to the skin, it promotes rapid healing of wounds and epithelization of erosion.
Indications
Local treatment: tonsillitis, infected wounds of various etiologies, burns (I-II cent.), Folliculitis, furuncle, carbuncle, acne vulgaris, impetigo, other inflammatory processes of the skin, erysipelas.
Composition
1 g contains sulfanilamide: para-aminobenzenesulfamide 10 mg.
Sulfanilamide is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Streptocid | Tula pharmaceutical factory | Russia | ointment |
| Streptocid | Nizhpharm | Russia | solution |
| Streptocid | Moscow Pharmaceutical Factory | Russia | powder |
| Streptocid | Tula pharmaceutical factory | Russia | powder |
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Dosage and Administration
For oral use. Adults on the first day of treatment prescribed in a dose of 500 mg 4 times / day.; on the 2nd day - 1 g 4 times / day; in the 3rd and following days - 1.5-2 g 4 times / day. After subsiding of the acute clinical symptoms of ulcerative colitis, Sulfasalazine-EN is prescribed in a maintenance dose of 500 mg 3-4 times / day. for several months.
Children aged 5-7 years should be prescribed 250-500 mg 3-6 times / day, children over 7 years old - 500 mg 3-6 times / day. Sulfasalazine-EH should be taken after meals.
Adverse reactions
On the part of the central nervous system and peripheral nervous system: headache, dizziness, tinnitus, ataxia, convulsions, sleep disorders, hallucinations, peripheral neuropathy.
On the part of the urinary system: renal dysfunction, interstitial nephritis.
On the part of the digestive system: nausea, vomiting, diarrhea, abdominal pain, anorexia, hepatitis, pancreatitis.
On the part of the respiratory system: interstitial pneumonitis and other lesions of the lung tissue.
From the hemopoietic system: anemia, leukopenia, thrombocytopenia, agranulocytosis.
Reproductive system: transient oligospermia, infertility.
Allergic reactions: skin rash, fever, anaphylactic shock.
Other: possible staining in yellow skin, urine, soft contact lenses.
Contraindications
- blood disorders;
- porphyria;
- severe liver dysfunction;
- severe renal impairment;
- deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- children up to 5 years;
- hypersensitivity to sulfanilamides and salicylic acid derivatives.
Pregnancy and Lactation
The use of Sulfasalazinee-EN in pregnancy is possible only under strict indications in the minimum effective dose. If the course of the disease allows, it is recommended to cancel the drug in the third trimester of pregnancy.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
- Brand name: Streptocid
- Active ingredient: Sulfanilamide
- Dosage form: Ointment.
- Manufacturer: Tula pharmaceutical factory
- Country of Origin: Russia
Studies and clinical trials of Sulfanilamide (Click to expand)
- Two ways of synthesis of polymer networks based on diglycidyl ether of bisphenol A, bisphenol A, and sulfanilamide: Kinetics study
- Processable heat-resistant polymers. VIII. Synthesis and characterization of polyamideimide from N-(4-carboxy phenyl) trimellitimide and sulfanilamide
- Molecular weight studies of the γ-irradiation degradation of poly(methyl methacrylate) doped with poly(p-sulfanilamide)
- The bone marrow of rats made anemic by administration of sulfanilamide
- The Characterization of the Silver Compounds of Some Sulfanilamide Derivatives
- Ionic Silver Compounds of Sulfanilamide Derivatives and Related Substances
- The Crystal and Molecular Structures of N4-(5-Bromosalicylidene)-N1-(3,4-dimethyl-5-isoxazolyl)sulfanilamide
- Der Wuchsstoff H′, ein Antagonist der Sulfanilamide, bei Streptobacterium plantarum (Orla - Jensen); Wachstum von Streptobacterium plantarum in Nährlösungen aus chemisch genau definierten Verbindungen
- ChemInform Abstract: Condensation Reactions of Trifluoronitrosomethane CF3NO with Sulfanilamide H2NC6H4SO2NH2 - Preparation of CF3N=NC6H4SO2NH2, CF3N= NC6H4SO2N=NCF3, CH3C(O)N(H)C6H4SO2N=NCF3 and CF3C(O)N(H)C6H4SO2NH2.
- Carbonic Anhydrase Inhibitors. Novel Sulfanilamide/Acetazolamide Derivatives Obtained by the Tail Approach and Their Interaction with the Cytosolic Isozymes I and II, and the Tumor-Associated Isozyme IX.
- ChemInform Abstract: Synthesis and Antiulcer Activity Study of 1,4-Dihydropyridines and Their Mannich Bases with Sulfanilamide.
- ChemInform Abstract: Synthesis of Novel Sulfanilamide-Derived 1,2,3-Triazoles and Their Evaluation for Antibacterial and Antifungal Activities.
- Zur Bestimmung des Cibazols und anderer Sulfanilamide
- The nature of enzyme inhibitions in bacterial luminescence: Sulfanilamide, urethane, temperature and pressure
- On the specificity of sulfanilamide action
- Micromelia and growth retardation as independent effects of sulfanilamide in chick embryos
- On the teratogenic interaction of sulfanilamide and 3-acetylpyridine in chick development
- Synthesis of some new derivatives of N4-p-cyanobenzoyl sulfanilamide
- Drug release from wax matrices II. Application of a mixture theory to the sulfanilamide—wax system
- Thiophene analogs of sulfanilamide: Bacterial growth inhibitors
- TLC determination of sulfanilamide as a degradation product in pharmaceutical preparations containing sodium sulfacetamide
- Quantitative analysis of sodium sulfacetamide solutions in the presence of hydrolysis products, sulfanilamide and sodium acetate
- A column chromatographic method for the determination of sulfanilamide in pharmaceutical preparations containing sulfacetamide or its sodium salt
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